Kuakini HHP Center for Translational Research on Aging: An Introduction

Abstract sKuakini Medical Center (Kuakini) is establishing an interdisciplinary Hawai’i-based Center of Biomedical Research Excellence (COBRE) for clinical and translational research on aging. - Specific Aim 1: Create a world class, innovative, interdisciplinary Center for Translational Research on Aging by building on the existing rare and valuable Kuakini Honolulu Heart Program (Kuakini HHP) and its related studies and research infrastructure. - Specific Aim 2: Advance the genomic, biological and clinical science of aging, and enhance the world class character of our Center, by enlisting accomplished senior scientists to mentor promising Hawaii-based new investigators in interdisciplinary aging research and career development. - Specific Aim 3: Elevate the capacity of our Center by: i) creating a state-of-the-art Clinical and Translational Core, and ii) collaborating with other Centers of Biomedical Research Excellence. This presentation will briefly introduce the Center and discuss its aims, research strategy, and future plans.

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Feasibility of common bibliometrics in evaluating translational science

Journal of Clinical and Translational Science ◽

10.1017/cts.2016.8 ◽

2017 ◽

Vol 1 (1) ◽

pp. 45-52 ◽

Cited By ~ 11

Author(s):

M. Schneider ◽

C. M. Kane ◽

J. Rainwater ◽

L. Guerrero ◽

G. Tong ◽

...

Keyword(s):

Pilot Study ◽

Translational Research ◽

State Of The Art ◽

National Institutes Of Health ◽

Translational Science ◽

Combined Analysis ◽

Shared Data ◽

Thomson Reuters ◽

Number Of Publications ◽

Clinical And Translational Research

IntroductionA pilot study by 6 Clinical and Translational Science Awards (CTSAs) explored how bibliometrics can be used to assess research influence.MethodsEvaluators from 6 institutions shared data on publications (4202 total) they supported, and conducted a combined analysis with state-of-the-art tools. This paper presents selected results based on the tools from 2 widely used vendors for bibliometrics: Thomson Reuters and Elsevier.ResultsBoth vendors located a high percentage of publications within their proprietary databases (>90%) and provided similar but not equivalent bibliometrics for estimating productivity (number of publications) and influence (citation rates, percentage of papers in the top 10% of citations, observed citations relative to expected citations). A recently available bibliometric from the National Institutes of Health Office of Portfolio Analysis, examined after the initial analysis, showed tremendous potential for use in the CTSA context.ConclusionDespite challenges in making cross-CTSA comparisons, bibliometrics can enhance our understanding of the value of CTSA-supported clinical and translational research.

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Clinical and Translational Research Ethics: Training Consultants and Biomedical Research Personnel

The American Journal of Bioethics ◽

10.1080/15265161.2017.1401172 ◽

2018 ◽

Vol 18 (1) ◽

pp. 57-61 ◽

Cited By ~ 3

Author(s):

Jason F. Arnold ◽

Andrea D. Boan ◽

Daniel T. Lackland ◽

Robert M. Sade

Keyword(s):

Research Ethics ◽

Translational Research ◽

Biomedical Research ◽

Ethics Training ◽

Research Personnel ◽

Clinical And Translational Research

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Kuakini HHP Center for Translational Research on Aging: Aims and Preliminary Findings

Innovation in Aging ◽

10.1093/geroni/igab046.1415 ◽

2021 ◽

Vol 5 (Supplement_1) ◽

pp. 367-367

Author(s):

Bradley Willcox ◽

Richard Allsopp ◽

Peter Martin

Keyword(s):

Translational Research ◽

Medical Center ◽

Telomerase Activity ◽

Attrition Rate ◽

Healthy Human ◽

Aging Research ◽

Attrition Rates ◽

Telomere Attrition ◽

Human Lifespan ◽

The Impact

Abstract Kuakini Medical Center (Kuakini) is creating an interdisciplinary Hawai’i-based Center for translational research on aging. This Center will build upon Kuakini’s five-decades of NIH-funded research, its 420,000-specimen biorepository, and existing strengths in aging research, notably, the 56-year ongoing Kuakini Honolulu Heart Program cohort study (Kuakini HHP), Kuakini Honolulu-Asia Aging Study (Kuakini HAAS), and Kuakini HHP Offspring Study. The overall goal is to find practical means to enhance healthy human lifespan (healthspan). Four research project leaders (RPLs) have been selected from various disciplines for mentorship in translational aging research. The first RPL presentation will introduce a novel mouse model, enabling controlled expression of the pro-longevity gene FoxO3, and assess the impact on lifespan and healthspan phenotypes in mice. These phenotypes will be compared to similar phenotypes in humans with/without the FOXO3 longevity genotype. The second RPL presentation will assess the relation between leukocyte telomere attrition rates (from banked blood collected at three time points over 20-plus years) in older Kuakini HHP men with/without the FOXO3 longevity genotype. The third RPL presentation will assess whether FOXO3 genotype, peripheral leukocyte telomere dynamics (attrition rate, telomerase activity) and inflammatory cytokines mediate the human brain integrity and function with age. This project will utilize structural and functional MRI data from male and female Kuakini HHP Offspring Study participants. The fourth RPL presentation will assess whether APOE e2, e4, and FOXO3 longevity-associated alleles impact 34-year incidence of intracerebral hemorrhage. We will summarize the findings, address the healthspan implications and provide future directions. Supported by NIH 5P20GM125526.

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