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2021 ◽  
Author(s):  
Ariann Nassel ◽  
Marta G Wilson-Barthes ◽  
Chanelle J. Howe ◽  
Sonia Napravnik ◽  
Michael J. Mugavero ◽  
...  

Methods. This protocol demonstrates how to: (1) securely geocode patients’ residential addresses in a clinic setting and match geocoded addresses to census tracts using Geographic Information System software (Esri, Redlands, CA); (2) ascertain contextual variables of the risk environment from the American Community Survey and ArcGIS Business Analyst (Esri, Redlands, CA); (3) use geoidentifiers to link neighborhood risk data to census tracts containing geocoded addresses; and (4) assign randomly generated identifiers to census tracts and strip census tracts of their geoidentifiers to maintain patient confidentiality. Results. Completion of this protocol generates three neighborhood risk indices (i.e., a Neighborhood Disadvantage Index, a Murder Rate Index, and a Assault Rate Index) for patients’ coded census tract locations. Intended Usage. This protocol can be used by research personnel and clinic staff who do not have prior GIS experience to easily create objective indices of the neighborhood risk environment while upholding patient confidentiality. Future studies can adapt this protocol to fit their specific patient populations and analytic objectives.


2021 ◽  
Author(s):  
Ariann Nassel, MA ◽  
Marta G G Wilson-Barthes ◽  
Chanelle J. Howe, PhD ◽  
Sonia Napravnik, PhD ◽  
Michael J. Mugavero, MD ◽  
...  

Methods. This protocol demonstrates how to: (1) securely geocode patients’ residential addresses in a clinic setting and match geocoded addresses to census tracts using Geographic Information System software (Esri, Redlands, CA); (2) ascertain contextual variables of the risk environment from the American Community Survey and ArcGIS Business Analyst (Esri, Redlands, CA); (3) use geoidentifiers to link neighborhood risk data to census tracts containing geocoded addresses; and (4) assign randomly generated identifiers to census tracts and strip census tracts of their geoidentifiers to maintain patient confidentiality. Results. Completion of this protocol generates three neighborhood risk indices (i.e., Neighborhood Disadvantage Index, Murder Rate Index, and Assault Rate Index) for patients’ coded census tract locations. Intended Usage. This protocol can be used by research personnel without prior GIS experience to easily create objective indices of the neighborhood risk environment while upholding patient confidentiality. Future studies can adapt this protocol to fit their specific patient populations and analytic objectives.


2021 ◽  
pp. 088506662110648
Author(s):  
Vincent I. Lau ◽  
Alexandra Binnie ◽  
John Basmaji ◽  
Nadia Baig ◽  
Dawn Opgenorth ◽  
...  

Background Critical care research in Canada is conducted primarily in academically-affiliated intensive care units with established research infrastructure, including research coordinators (RCs). Recently, efforts have been made to engage community hospital ICUs in research albeit with barriers. Automation or artificial intelligence (AI) could aid the performance of routine research tasks. It is unclear which research study processes might be improved through AI automation. Methods We conducted a cross-sectional survey of Canadian ICU research personnel. The survey contained items characterizing opinions regarding research processes that may be amenable to AI automation. We distributed the questionnaire via email distribution lists of 3 Canadian research societies. Open-ended questions were analyzed using a thematic content analysis approach. Results A total of 49 survey responses were received (response rate: 8%). Tasks that respondents felt were time-consuming/tedious/tiresome included: screening for potentially eligible patients (74%), inputting data into case report forms (65%), and preparing internal tracking logs (53%). Tasks that respondents felt could be performed by AI automation included: screening for eligible patients (59%), inputting data into case report forms (55%), preparing internal tracking logs (51%), and randomizing patients into studies (45%). Open-ended questions identified enthusiasm for AI automation to improve information accuracy and efficiency while freeing up RCs to perform tasks that require human interaction. This enthusiasm was tempered by the need for proper AI education and oversight. Conclusions There were balanced supportive (increased efficiency and re-allocation of tasks) and challenges (informational accuracy and oversight) with regards to AI automation in ICU research.


2021 ◽  
pp. 014544552110540
Author(s):  
Hide Okuno ◽  
Taylor Rezeppa ◽  
Tabitha Raskin ◽  
Andres De Los Reyes

Socially anxious adolescents often endure anxiety-provoking situations using safety behaviors: strategies for minimizing in-the-moment distress (e.g., avoiding eye contact, rehearsing statements before entering a conversation). Studies linking safety behaviors to impaired functioning have largely focused on adults. In a sample of one hundred thirty-four 14 to 15 year-old adolescents, we tested whether levels of safety behaviors among socially anxious adolescents relate to multiple domains of impaired functioning. Adolescents, parents, and research personnel completed survey measures of safety behaviors and social anxiety, adolescents and parents reported about adolescents’ evaluative fears and psychosocial impairments, and adolescents participated in a set of tasks designed to simulate social interactions with same-age, unfamiliar peers. Relative to other adolescents in the sample, adolescents high on both safety behaviors and social anxiety displayed greater psychosocial impairments, evaluative fears, and observed social skills deficits within social interactions. These findings have important implications for assessing and treating adolescent social anxiety.


2021 ◽  
Vol 25 (5) ◽  
pp. 587-590
Author(s):  
Doyle Bosque ◽  
Sheryl Forbes ◽  
Erica Ward ◽  
Joelle Delaney ◽  
G. Tobin Meyers

Author(s):  
Tasneem Pervez ◽  
Sayyad Zahid Qamar ◽  
Maaz Akhtar ◽  
Moosa Al Kharusi

AbstractIn the petroleum industry, packers refer to the components/products which are used to isolate one section in a formation from others, or to isolate the outer section of a production tubing from the inner section, which may be a casing or a liner or the wellbore itself. Mechanical packers are installed through some form of tubing movement. Permanent packers are low in cost and provide better seal. Retrievable packers have lower sealing capability but are re-usable after repair, and therefore expensive. More innovative packers made of swellable elastomers are rather new. These elastomers swell when they come in contact with different types of fluids (mostly water and oil). Like a casing, these new packers are lowered to the desired depth and allowed to swell before production or injection operations begin. Various studies have been published about the swelling and mechanical response of these elastomers. However, many questions remain about the sealing performance of swell packers, and their effectiveness in actual wellbores of rough and random profiles. This paper describes the design and development of an experimental unit for performance testing of a mix of inert and swelling elastomer seals under realistic well conditions. Actual swell packers and petroleum tubulars are housed in a concrete block that replicates open-hole and cased-hole wells through layers of varying roughness. This is a one-of-its-kind unit providing full-scale demonstration about the working of swell packers against outer casing or rock formation in a wellbore. It is also a complete testing apparatus to investigate the behavior of swell packers made of fast-swell and medium-swell elastomers, and how they seal off irregular boreholes. This work can provide basic understanding and visual corroboration to petroleum engineers and students, swelling elastomer application developers, and academic and research personnel.


Author(s):  
Vadim Lazutkin

The specifics of research and academic profession presuppose special approaches to personnel management and motivation. The selection of adequate motivational tools is often done by trial and error. The paper attempts to substantiate short-term and long-term methods of motivating scientific personnel. The experiment featured the case of a Russian biotechnological company, whose personnel underwent S. Ritchie and P. Martin’s Motivational Profile Test. The dominant factors of job satisfaction included self-development opportunities, recognition, ambitious goals, creative tasks, etc. The authors developed some ways for the further development of methods for motivating research personnel.


2021 ◽  
pp. OP.21.00169
Author(s):  
David E. Gerber ◽  
Valerie L. Clark ◽  
Thomas Y. Sheffield ◽  
M. Shaalan Beg ◽  
Yang Xie ◽  
...  

PURPOSE: The COVID-19 pandemic has led to profound changes in clinical research, including remote consent, telehealth, off-site procedures, shipment of therapy, and remote study monitoring. We assessed longitudinal perceptions of these adjustments among clinical research professionals. METHODS: We distributed an anonymous survey assessing experiences, perceptions, and recommendations regarding COVID-19–related clinical research adjustments to cancer clinical research office personnel in May 2020 and again in November 2020. Responses were compared using Fisher's exact and Mann-Whitney U tests. RESULTS: A total of 90 of 102 invited research personnel (88%) responded. Fifty-three (59%) reported participating in both initial and follow-up surveys. The proportion of respondents reporting personal experience with COVID-19–related adjustments increased over time, particularly for remote initial consent (29% v 4%), remote reconsent (24% v 9%), and remote study monitoring (36% v 22%). Perceived impact of COVID-19–related adjustments on data quality ( P = .02) and patient experience ( P = .002) improved significantly. However, perceived effect on patient safety ( P = .02) and respondent's experience ( P = .09) became less favorable. Individuals with personal experience with the adjustment were more likely to recommend continuing remote consent (62% v 38%; P = .04), remote monitoring (69% v 45%; P = .05), and therapy shipment (67% v 35%; P = .01) after the COVID-19 pandemic, with nonsignificant trends for off-site diagnostics (44% v 24%; P = .13) and telehealth visits (66% v 45%; P = .08). CONCLUSION: More than 6 months into the global pandemic, perceptions of COVID-19–related clinical research changes remain favorable. Experienced individuals are more likely to recommend that these changes continue in the future.


2021 ◽  
Vol 8 ◽  
Author(s):  
David C. Sheridan ◽  
Robert L. Cloutier ◽  
Ravi Samatham ◽  
Matthew L. Hansen

Background: Peripheral perfusion assessment is used routinely at the bedside by measuring the capillary refill time (CRT). Recent clinical trials have shown evidence to its ability to recognize conditions with decreased end organ perfusion as well as guiding therapeutic interventions in sepsis. However, the current standard of physician assessment at the bedside has shown large variability. New technology can improve the precision and repeatability of CRT affecting translation of previous high impact research.Methods: This was a prospective, observational study in the intensive care unit and emergency department at a quaternary care hospital using a non-invasive finger sensor for CRT. The device CRT was compared to the gold standard of trained research personnel assessment of CRT as well as to providers clinically caring for the patient.Results: Pearson correlations coefficients were performed across 89 pairs of measurements. The Pearson correlation for the device CRT compared to research personnel CRT was 0.693. The Pearson correlation for the provider CRT compared to research personnel CRT was 0.359.Conclusions: New point-of-care technology shows great promise in the ability to improve peripheral perfusion assessment performed at the bedside in the emergency department triage and during active resuscitation. This standardized approach allows for better translation of prior research that is limited by the subjectivity of manual visual assessment of CRT.


Pathogens ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 780
Author(s):  
Lin Wang ◽  
Chunnan Liang ◽  
Xiaobo Li ◽  
Ji Wang ◽  
Rui Fu ◽  
...  

Hepatitis E virus (HEV) is zoonotic and the leading cause of acute viral hepatitis worldwide. Rabbit HEV can infect humans and is prevalent globally. It is reported that laboratory rabbits are also naturally infected with HEV. Therefore, it is important to investigate in a large scale the prevalence of HEV in laboratory rabbits. Serum samples were collected from 649 laboratory rabbits of 13 different commercial vendors in Beijing, China, from 2017 to 2019, and anti-HEV and HEV antigen (Ag) were tested. Fecal samples were collected from 50 laboratory rabbits from one of the vendors for HEV RNA detection. Six laboratory rabbits with natural HEV infection were euthanized and their liver, kidney, bile and urine samples were collected for HEV RNA quantification. Liver tissues were subjected to histopathology analysis. The overall positive rates of anti-HEV antibodies and HEV-Ag are 2.6% (15/588) and 7.9% (51/649), respectively. HEV RNA was detected in 12.0% (6/50) of the rabbits. High viral load of HEV RNA was detected in liver and bile samples. Liver inflammation was observed. HEV is circulating in laboratory rabbit population in China. Strict screening is crucial to ensure experimental accuracy and prevent zoonotic transmission to research personnel.


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