scholarly journals Does HbA1c Influence the Relationship between Stress and Cognition? Findings from the VA Normative Aging Study

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 704-704
Author(s):  
Austin Brockmann ◽  
Carolyn Aldwin ◽  
Avron Spiro
Keyword(s):  
Pattern Recognition ◽  
Verbal Fluency ◽  
Word List ◽  
Cognitive Outcomes ◽  
Age Group ◽  
Normative Aging Study ◽  
Aging Study ◽  
Normative Aging ◽  
The Relationship ◽  
Young Old

Abstract Type 2 diabetes has increased in prevalence globally, with potential adverse effects on cognition. Both high levels of hemoglobin A1c (HbA1c) and stressful life events (SLEs) are associated with impaired cognitive performance, but few studies have examined their synergistic effects. The present study examined direct effects of stress and HbA1c on several cognitive outcomes, and whether HbA1c moderated the relationship between SLEs and cognition. Utilizing a sample of 527 older men from the VA Normative Aging Study (Mage = 74.3, SD = 6.5), stress was inversely related to MMSE, verbal fluency, and pattern recognition; HbA1c was only inversely associated with MMSE. The moderation model was supported only for pattern recognition (𝛽 = 1.64, p < .05), with stress having worse effects in those high in HbA1c. Stratifying analyses by age group (<75, 75+) showed that stress predicted cognition only in the young-old, while HbA1c was inversely related to cognition only in old-old participants. Further, these age-group analyses yielded different effects of demographics on cognition. In the young-old, age was consistently inversely related to all cognitive outcomes, but in the old-old only with MMSE and word list recall. Among the young-old, education was associated with only word list recall but improved performance for most scales among the old-old. Finally, HbA1c intensified the effect of stress moderation on verbal fluency only in old-old (𝛽 = 2.78, p < .05). In summary, stress was more important for cognition in the young-old, while education and health status were more important in the old-old.

scholarly journals Stroke Risk Predicts Verbal Fluency Decline in Healthy Older Men: Evidence From the Normative Aging Study

2001 ◽  
Vol 56 (6) ◽  
pp. P340-P346 ◽  
Author(s):  
C. B. Brady ◽  
A. Spiro ◽  
R. McGlinchey-Berroth ◽  
W. Milberg ◽  
J. M. Gaziano
Keyword(s):  
Verbal Fluency ◽  
Stroke Risk ◽  
Older Men ◽  
Normative Aging Study ◽  
Aging Study ◽  
Normative Aging

The Normative Aging Study: An Interdisciplinary and Longitudinal Study of Health and Aging

1972 ◽  
Vol 3 (1) ◽  
pp. 5-17 ◽  
Author(s):  
Benjamin Bell ◽  
Charles L. Rose ◽  
Albert Damon
Keyword(s):  
Longitudinal Study ◽  
Clinical Medicine ◽  
Longitudinal Design ◽  
Outpatient Basis ◽  
Research Subjects ◽  
Aging Effects ◽  
Normative Aging Study ◽  
Aging Study ◽  
Normative Aging ◽  
The Relationship

The Normative Aging Study is a comprehensive interdisciplinary longitudinal study located in the VA Outpatient Clinic in Boston, Mass. The study was inaugurated in 1963 by the VA because of its statutory responsibility for the medical care of 25 million war veterans of whom 2 million are now 65 years of age and over, a figure which will rise to over 7 million in the next 20 years. Approximately 2,000 male veterans are enrolled for their lifetime as research subjects and undergo recurrent examinations administered on an outpatient basis. The focus of the study is on non-pathological aging, so that the subjects were carefully screened in advance to satisfy rigid health criteria regardless of age. The study is distinctive because of its large N and the socioeconomic diversity of its population. Parameters include clinical medicine, biochemistry, special senses, oral medicine, anthropometry and behavior. The study is designed to investigate the relationship between normal aging and the natural history of chronic diseases. The investigation of environmental correlates of age change throughout the logitudinal design will also suggest the intrinsic or extrinsic nature of the aging process. The hybrid cross-sectional-longitudinal design will also enable the partialing of secular from true aging effects. Functional ages pertaining to various aspects of aging are being developed as a tool for assessing relative aging rates and the relationship among such differences in aging.

scholarly journals The Relationship of Blood Lead and Dietary Calcium to Blood Pressure in the Normative Aging Study

1996 ◽  
Vol 25 (3) ◽  
pp. 528-536 ◽  
Author(s):  
SUSAN P PROCTOR ◽  
ANDREA ROTNITZKY ◽  
DAVID SPARROW ◽  
SCOTT T WEISS ◽  
HOWARD HU
Keyword(s):  
Blood Pressure ◽  
Blood Lead ◽  
Dietary Calcium ◽  
Normative Aging Study ◽  
Aging Study ◽  
Normative Aging ◽  
Relationship Of ◽  
The Relationship

Leisure Activities, Stress, and Health among Bereaved and Non-Bereaved Elderly Men: The Normative Aging Study

2001 ◽  
Vol 43 (3) ◽  
pp. 217-245 ◽  
Author(s):  
Tanya R. Fitzpatrick ◽  
Avron Spiro ◽  
Nancy R. Kressin ◽  
Evelyn Greene ◽  
Raymond Bossé
Keyword(s):  
Leisure Activities ◽  
Hierarchical Regression ◽  
Negative Effects ◽  
Elderly Men ◽  
Normative Aging Study ◽  
Effect Model ◽  
Aging Study ◽  
Normative Aging ◽  
The Relationship ◽  
Stress And Health

Few studies have examined the effect that a resource such as leisure activities might have on the relationship between stress and health among elderly men. Data from the Normative Aging Study (NAS) were used to examine whether specific groups of leisure activities (social, solitary, and mixed activities; activities performed either alone or with others) moderated the effect of stress on the health of elderly men and whether there were differences in this effect between bereaved and non-bereaved men. The sample of 799 men was divided into two groups: a group bereaved of family and friends and a group of non-bereaved. Hierarchical regression analyses compared an initial model, a direct effect model, and a moderating model. The results indicate that for both groups of men, mixed leisure activities moderated the effect of stress on physical but not mental health. Additionally, for the bereaved group, social activities moderated the effects of stress on physical health. The negative effects of life stressors (other than bereavement) can be moderated by engaging in leisure activities for both bereaved and non-bereaved elderly men. Implications of the findings for future practice and research are discussed.

The Relationship of Nonspecific Airway Responsiveness and Atopy to the Rate of Decline of Lung function: The Normative Aging Study

1990 ◽  
Vol 141 (3) ◽  
pp. 589-594 ◽  
Author(s):  
Donna R. Parker ◽  
George T. O'Connor ◽  
David Sparrow ◽  
Mark R. Segal ◽  
Scott T. Weiss ◽  
...  
Keyword(s):  
Lung Function ◽  
Airway Responsiveness ◽  
Normative Aging Study ◽  
Aging Study ◽  
Normative Aging ◽  
Rate Of Decline ◽  
Relationship Of ◽  
The Relationship

The relationship of epinephrine excretion to serum lipid levels: The normative aging study

Metabolism ◽  
1994 ◽  
Vol 43 (4) ◽  
pp. 509-513 ◽  
Author(s):  
Kenneth D. Ward ◽  
David Sparrow ◽  
Lewis Landsberg ◽  
James B. Young ◽  
Pantel S. Vokonas ◽  
...  
Keyword(s):  
Serum Lipid ◽  
Lipid Levels ◽  
Serum Lipid Levels ◽  
Normative Aging Study ◽  
Aging Study ◽  
Normative Aging ◽  
Relationship Of ◽  
The Relationship
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