Detection of cytokines (interleukin-1, interleukin-6, transforming growth factor- ) and soluble tumour necrosis factor receptors in embryo culture fluids during in-vitro fertilization

1995 ◽  
Vol 10 (1) ◽  
pp. 171-176 ◽  
Author(s):  
R. Austgulen ◽  
K.J. Arntzen ◽  
L.J. Vatten ◽  
J. Kahn ◽  
A. Sunde
Keyword(s):  
Growth Factor ◽  
In Vitro Fertilization ◽  
Embryo Culture ◽  
Interleukin 6 ◽  
Tumour Necrosis ◽  
Transforming Growth Factor ◽  
Interleukin 1 ◽  
Vitro Fertilization ◽  
Necrosis Factor

scholarly journals Transforming growth factor β2 differentially modulates interleukin-1 β- and tumour-necrosis-factor-α-stimulated phospholipase A2 and prostaglandin E2 synthesis in rat renal mesangial cells

1990 ◽  
Vol 270 (1) ◽  
pp. 269-271 ◽  
Author(s):  
J Pfeilschifter ◽  
W Pignat ◽  
J Leighton ◽  
F Märki ◽  
K Vosbeck ◽  
...  
Keyword(s):  
Growth Factor ◽  
Phospholipase A2 ◽  
Tumour Necrosis ◽  
Transforming Growth Factor ◽  
Mesangial Cells ◽  
Interleukin 1 ◽  
Tnf Alpha ◽  
Tgf Beta ◽  
Beta 2 ◽  
Necrosis Factor

Treatment of rat glomerular mesangial cells with transforming growth factor beta 2 (TGF beta 2) stimulates prostaglandin E2 (PGE2) synthesis. Actinomycin D, cycloheximide and diclofenac attenuate the TGF beta 2-induced PGE2 formation. As shown previously, two proinflammatory cytokines, interleukin 1 beta (IL-1 beta) and tumour necrosis factor alpha (TNF alpha), are potent stimuli for PGE2 and phospholipase A2 secretion from mesangial cells. We report here that, whereas TGF beta 2 potentiates the IL-1 β- and TNF alpha-evoked PGE2 production, it strongly inhibits the phospholipase A2 secretion induced by both cytokines. In addition, the inhibitory effect of TGF beta 2 on phospholipase A2 secretion is not due to the augmented PGE2 formation.

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