scholarly journals 185 * RED BLOOD CELL DISTRIBUTION WIDTH PREDICTS MORBIDITY AND MORTALITY AFTER AORTIC VALVE REPLACEMENT

2014 ◽  
Vol 19 (suppl 1) ◽  
pp. S55-S56
Author(s):  
C. Pisano ◽  
C. R. Balistreri ◽  
D. Merlo ◽  
V. Argano ◽  
O. F. Triolo ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Replacement ◽  
Blood Cell ◽  
Valve Replacement ◽  
Red Blood Cell ◽  
Morbidity And Mortality ◽  
Cell Distribution ◽  
Distribution Width ◽  
Red Blood Cell Distribution

Prognostic Value of Red Blood Cell Distribution Width in Transcatheter Aortic Valve Replacement Patients

2021 ◽  
pp. 155698452110413
Author(s):  
Seyed Hossein Aalaei-Andabili ◽  
R. David Anderson ◽  
Anthony A. Bavry ◽  
Brian Barr ◽  
George J. Arnaoutakis ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Replacement ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Transcatheter Aortic Valve Replacement ◽  
Prognostic Value ◽  
Cell Distribution ◽  
Distribution Width ◽  
Transcatheter Aortic Valve ◽  
Red Blood Cell Distribution

Objective Elevated red blood cell distribution width (RDW) level has been shown to be associated with poor outcomes in patients with cardiovascular disease. Limited data are available regarding the prognostic value of RDW in transcatheter aortic valve replacement (TAVR) patients. Therefore, we aimed to investigate the impact of RDW variation on outcomes of TAVR patients. Methods From March 20, 2012, to February 20, 2020, the pre-TAVR RDW levels of 1,163 consecutive TAVR patients were examined. Receiver operating curves were set to define the most accurate cut-point, which was subsequently validated in our validation set. Associations of RDW levels with early and long-term outcomes were investigated. Results A total of 988 patients were eligible for the analysis. Patients with 30-day, 1-year, and 7-year mortality had significantly higher pre-TAVR RDW levels (15.8% [12.9-19.1] vs 14.7% [11.6-26.3], P = 0.01; 16% [12.3-26.3] vs 14.7% [11.6-24.3], P < 0.001; 15.6% [12.3-26.3] vs 14.6% [11.6-24.3], P < 0.001, respectively). A RDW of 14.5% was found as the most sensitive and specific cut-point for mortality at 1 and 7 years (HR = 2.6, 95% CI: 1.6-4.2, P < 0.001; HR = 1.8, 95% CI: 1.3-2.4, P < 0.001), with mortality of 22% versus 10% at 1 year ( P < 0.001) and 37% versus 27% at 7 years ( P < 0.001) in patients with RDW ≥14.5% versus those with RDW <14.5%. Conclusions RDW is an important prognostic factor in TAVR patients. A RDW level higher than 14.5% is significantly associated with post-TAVR early and late mortality. RDW levels should be incorporated into current risk assessment models as an additional variable to predict post-TAVR outcomes.

scholarly journals Red blood cell distribution width as a prognostic factor in patients undergoing transcatheter aortic valve implantation

2019 ◽  
Vol 74 (3) ◽  
pp. 212-216 ◽  
Author(s):  
Yishay Szekely ◽  
Ariel Finkelstein ◽  
Samuel Bazan ◽  
Amir Halkin ◽  
Maria Abbas Younis ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Aortic Valve ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Transcatheter Aortic Valve ◽  
Aortic Valve Implantation ◽  
Valve Implantation ◽  
Red Blood Cell Distribution

Red blood cell distribution width predicts one-year mortality following transcatheter aortic valve implantation

2014 ◽  
Vol 172 (2) ◽  
pp. 456-457 ◽  
Author(s):  
Caroline J. Magri ◽  
Alaide Chieffo ◽  
Azeem Latib ◽  
Matteo Montorfano ◽  
Francesco Maisano ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Transcatheter Aortic Valve ◽  
Aortic Valve Implantation ◽  
One Year ◽  
Valve Implantation ◽  
Red Blood Cell Distribution

scholarly journals Red Blood Cell Distribution Width in Hospitalized COVID-19 Patients

2022 ◽  
Vol 8 ◽  
Author(s):  
Preethi Ramachandran ◽  
Mahesh Gajendran ◽  
Abhilash Perisetti ◽  
Karim Osama Elkholy ◽  
Abhishek Chakraborti ◽  
...  
Keyword(s):  
Septic Shock ◽  
Mechanical Ventilation ◽  
Blood Cell ◽  
Hospital Mortality ◽  
Red Blood Cell ◽  
Morbidity And Mortality ◽  
Cell Distribution ◽  
Distribution Width ◽  
Increased Risk ◽  
Red Blood Cell Distribution

Introduction: Coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is causing dramatic morbidity and mortality worldwide. The Red Blood Cell Distribution Width (RDW) has been strongly associated with increased morbidity and mortality in multiple diseases.Objective: To assess if elevated RDW is associated with unfavorable outcomes in hospitalized COVID-19.Methods: We retrospectively studied clinical outcomes of hospitalized COVID-19 patients for their RDW values. In-hospital mortality was defined as primary outcome, while septic shock, need for mechanical ventilation, and length of stay (LOS) were secondary outcomes.Results: A total of 294 COVID-19 patients were finally studied. Overall prevalence of increased RDW was 49.7% (146/294). RDW was associated with increased risk of in-hospital mortality (aOR, 4.6; 95%CI, 1.5-14.6) and septic shock (aOR, 4.6; 95%CI, 1.4-15.1) after adjusting for anemia, ferritin, lactate, and absolute lymphocyte count. The association remained unchanged even after adjusting for other clinical confounders such as age, sex, body mass index, coronary artery disease, hypertension, diabetes mellitus, and chronic obstructive pulmonary disease. No association was found instead with mechanical ventilation and median LOS.Conclusion: Elevated RDW in hospitalized COVID-19 patients is associated with a significantly increased risk of mortality and septic shock.

scholarly journals Red blood cell distribution width (RDW) in Hospitalized COVID-19 Patients

2020 ◽  
Author(s):  
Preethi Ramachandran ◽  
Mahesh Gajendran ◽  
Abhilash Perisetti ◽  
Karim Osama Elkholy ◽  
Abhishek Chakraborti ◽  
...  
Keyword(s):  
Septic Shock ◽  
Mechanical Ventilation ◽  
Blood Cell ◽  
Hospital Mortality ◽  
Red Blood Cell ◽  
Morbidity And Mortality ◽  
Cell Distribution ◽  
Distribution Width ◽  
Increased Risk ◽  
Red Blood Cell Distribution

AbstractIntroductionCoronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is causing dramatic morbidity and mortality worldwide. The Red Blood Cell Distribution Width (RDW) has been strongly associated with increased morbidity and mortality in multiple diseases.ObjectiveTo assess if elevated RDW is associated with unfavorable outcomes in hospitalized COVID-19.MethodsWe retrospectively studied clinical outcomes of hospitalized COVID-19 patients for their RDW values. In-hospital mortality was defined as primary outcome, while septic shock, need for mechanical ventilation, and length of stay (LOS) were secondary outcomes.ResultsA total of 294 COVID-19 patients were finally studied. Overall prevalence of increased RDW was 49.7% (146/294). RDW was associated with increased risk of in-hospital mortality (aOR, 4.5; 95%CI, 1.4-14.3) and septic shock (aOR, 4.6; 95%CI, 1.4-15.1) after adjusting for anemia, ferritin, and lactate. The association remained unchanged even after adjusting for other clinical confounders such as age, sex, body mass index, coronary artery disease, hypertension, diabetes mellitus, and chronic obstructive pulmonary disease. No association was found instead with mechanical ventilation and median LOS.ConclusionElevated RDW in hospitalized COVID-19 patients is associated with a significantly increased risk of mortality and septic shock.

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