scholarly journals Red Blood Cell Distribution Width in Hospitalized COVID-19 Patients

2022 ◽  
Vol 8 ◽  
Author(s):  
Preethi Ramachandran ◽  
Mahesh Gajendran ◽  
Abhilash Perisetti ◽  
Karim Osama Elkholy ◽  
Abhishek Chakraborti ◽  
...  
Keyword(s):  
Septic Shock ◽  
Mechanical Ventilation ◽  
Blood Cell ◽  
Hospital Mortality ◽  
Red Blood Cell ◽  
Morbidity And Mortality ◽  
Cell Distribution ◽  
Distribution Width ◽  
Increased Risk ◽  
Red Blood Cell Distribution

Introduction: Coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is causing dramatic morbidity and mortality worldwide. The Red Blood Cell Distribution Width (RDW) has been strongly associated with increased morbidity and mortality in multiple diseases.Objective: To assess if elevated RDW is associated with unfavorable outcomes in hospitalized COVID-19.Methods: We retrospectively studied clinical outcomes of hospitalized COVID-19 patients for their RDW values. In-hospital mortality was defined as primary outcome, while septic shock, need for mechanical ventilation, and length of stay (LOS) were secondary outcomes.Results: A total of 294 COVID-19 patients were finally studied. Overall prevalence of increased RDW was 49.7% (146/294). RDW was associated with increased risk of in-hospital mortality (aOR, 4.6; 95%CI, 1.5-14.6) and septic shock (aOR, 4.6; 95%CI, 1.4-15.1) after adjusting for anemia, ferritin, lactate, and absolute lymphocyte count. The association remained unchanged even after adjusting for other clinical confounders such as age, sex, body mass index, coronary artery disease, hypertension, diabetes mellitus, and chronic obstructive pulmonary disease. No association was found instead with mechanical ventilation and median LOS.Conclusion: Elevated RDW in hospitalized COVID-19 patients is associated with a significantly increased risk of mortality and septic shock.

scholarly journals Red blood cell distribution width (RDW) in Hospitalized COVID-19 Patients

2020 ◽  
Author(s):  
Preethi Ramachandran ◽  
Mahesh Gajendran ◽  
Abhilash Perisetti ◽  
Karim Osama Elkholy ◽  
Abhishek Chakraborti ◽  
...  
Keyword(s):  
Septic Shock ◽  
Mechanical Ventilation ◽  
Blood Cell ◽  
Hospital Mortality ◽  
Red Blood Cell ◽  
Morbidity And Mortality ◽  
Cell Distribution ◽  
Distribution Width ◽  
Increased Risk ◽  
Red Blood Cell Distribution

AbstractIntroductionCoronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is causing dramatic morbidity and mortality worldwide. The Red Blood Cell Distribution Width (RDW) has been strongly associated with increased morbidity and mortality in multiple diseases.ObjectiveTo assess if elevated RDW is associated with unfavorable outcomes in hospitalized COVID-19.MethodsWe retrospectively studied clinical outcomes of hospitalized COVID-19 patients for their RDW values. In-hospital mortality was defined as primary outcome, while septic shock, need for mechanical ventilation, and length of stay (LOS) were secondary outcomes.ResultsA total of 294 COVID-19 patients were finally studied. Overall prevalence of increased RDW was 49.7% (146/294). RDW was associated with increased risk of in-hospital mortality (aOR, 4.5; 95%CI, 1.4-14.3) and septic shock (aOR, 4.6; 95%CI, 1.4-15.1) after adjusting for anemia, ferritin, and lactate. The association remained unchanged even after adjusting for other clinical confounders such as age, sex, body mass index, coronary artery disease, hypertension, diabetes mellitus, and chronic obstructive pulmonary disease. No association was found instead with mechanical ventilation and median LOS.ConclusionElevated RDW in hospitalized COVID-19 patients is associated with a significantly increased risk of mortality and septic shock.

scholarly journals The Clinical Value of Red Blood Cell Distribution Width as a Prognosis Factor and Severity Marker in Sepsis and Septic Shock

2019 ◽  
Vol 2 (1) ◽  
pp. 58-66
Author(s):  
Emanuel Moisă ◽  
Silvius Negoiţă ◽  
Dan Corneci
Keyword(s):  
Septic Shock ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Hematological Parameter ◽  
Component Part ◽  
Cell Distribution ◽  
Prognosis Factor ◽  
Distribution Width ◽  
Severity Scores ◽  
Red Blood Cell Distribution

AbstractRed blood cell distribution width (RDW) is a hematological parameter usually measured with every complete blood count. Its place in daily practice is mainly in the differential diagnosis of anemia, but nowadays, researchers are focused on different approaches for the erythrocyte’s changes in function and morphology.Sepsis and its most advanced form, septic shock, induces profound disturbances into organ system’s function and morphology. The red blood cells physiology and structure are directly and indirectly altered by these im balances produced in sepsis. RDW was studied in many diseases, like acute heart failure, acute stroke, inflammatory bowel diseases, chronic lung diseases and cancer, but also in sepsis. Its changes are seen to be mainly associated with prognosis. Higher values of RDW are correlated with mortality and severity of illnes in septic and all-cause critically ill patients. RDW was studied also as an independent variable in different predictive scores and some studies suggest it should be introduced in the scores use on a daily basis in critical care settings and emergency departments.In this review we will focus on how RDW was associated with mortality and severity of illness in the recent literature, as an independent prognosis factor and as a component part in different predictive and severity scores.

Red blood cell distribution width and the risk of cardiovascular morbidity and all-cause mortality

2014 ◽  
Vol 111 (02) ◽  
pp. 300-307 ◽  
Author(s):  
Dahlia Weitzman ◽  
Raanan Raz ◽  
Arie Steinvil ◽  
David Zeltser ◽  
Shlomo Berliner ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cardiovascular Events ◽  
Cardiovascular Morbidity ◽  
Cell Distribution ◽  
Distribution Width ◽  
Major Cardiovascular Events ◽  
Increased Risk ◽  
All Cause Mortality ◽  
Red Blood Cell Distribution

SummaryRed blood cell distribution width (RDW) has been shown to predict cardiovascular mortality in various populations, but studies were less conclusive regarding cardiovascular morbidity. We aimed at evaluating the prognostic effect of RDW on cardiovascular morbidity and allcause mortality in the largest community cohort to date. We utilised the computerised database of a large community based healthcare maintenance organization (HMO) in Israel to identify a cohort of 225,006 eligible patients aged 40 or above who performed a blood count during 2006. We evaluated the relationship between 1% increments of RDW values and major cardiovascular events and all-cause mortality over a period of five years. A total of 21,939 incident cases of a major cardiovascular event and 4,287 deaths were documented during a total of six years of follow up, respectively. In comparison with patients with RDW level <13%, the hazard ratio for total mortality gradually increased to 4.57 (95% confidence interval [CI]: 3.35–6.24, p<0.001) among male patients and to 3.26 (95% CI: 2.49–4.28, p<0.001) among female patients with a RDW of 17% or above. Similar results were evident in anaemic and non-anaemic populations. RDW above 17% was also associated with a modest increased risk of major cardiovascular events in females 1.26 (95% CI: 1.03–1.52, p=0.021), while in men it was not significant, 1.08 (95% CI: 0.82–1.41, p=NS). In conclusion, increasing RDW levels significantly increased risk of cardiovascular morbidity and all-cause mortality. Our observation is evident in both anaemic and non-anaemic patients.

scholarly journals An increase in red blood cell distribution width from baseline predicts mortality in patients with severe sepsis or septic shock

Critical Care ◽  
2013 ◽  
Vol 17 (6) ◽  
pp. R282 ◽  
Author(s):  
Chan Ho Kim ◽  
Jung Tak Park ◽  
Eun Jin Kim ◽  
Jae Hyun Han ◽  
Ji Suk Han ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Red Blood Cell Distribution

scholarly journals Role of red blood cell distribution width in predicting the prognosis of patients with sepsis

2019 ◽  
pp. 102490791986064
Author(s):  
Jian Zhang ◽  
Xin-hua He ◽  
Jun Yang ◽  
Shu-bin Guo
Keyword(s):  
Septic Shock ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Rapid Development ◽  
Sepsis Group ◽  
Cell Distribution ◽  
Survival Group ◽  
Distribution Width ◽  
Cox Regression Analysis ◽  
Red Blood Cell Distribution

Background: Sepsis is a dangerous disease with rapid development and high mortality rate, which is an important cause of death for critically ill patients. Therefore, timely and accurate assessment of patients’ condition is beneficial to improve prognosis and reduce mortality. Objective: This study was designed to investigate the potential correlation between red blood cell distribution width and 28-day prognosis of patients with sepsis. Methods: A prospective observational study enrolling 236 patients with sepsis or septic shock was performed at our hospital. All cases were divided into survival versus non-survival group on 28th day after diagnosis. The two groups were compared for general condition, underlying diseases, quick Sequential Organ Failure Assessment, Acute Physiology and Chronic Health Evaluation II score, C-reactive protein, procalcitonin, and red blood cell distribution width at admission. Results: The red blood cell distribution width level in non-survivors was higher than that in survivors (16.3 ± 2.8 vs 15.2 ± 1.7, p = 0.013). Cox regression analysis indicated that red blood cell distribution width was an independent predictor for 28-day mortality (hazard ratio: 1.311, 95% confidence interval: 1.119–3.011, p = 0.018). The red blood cell distribution width cutoff value of red blood cell distribution width for 28-day mortality was 16.1%, while patients with lower red blood cell distribution width levels had a better prognosis as demonstrated by Kaplan–Meier survival curves (log-rank = 7.398, p = 0.007). Unlike the septic shock group, in the sepsis group, the red blood cell distribution width level was higher in the non-survival group compared to the survival group (15.82% ± 0.93% vs 15.01% ± 0.89%, p < 0.001). Conclusion: Increased red blood cell distribution width may be an important predictor of disease progression and prognosis in patients with sepsis and septic shock. In the sepsis group, higher red blood cell distribution width levels predict poor prognosis.

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