scholarly journals Global Disease Burden Estimates of Respiratory Syncytial Virus–Associated Acute Respiratory Infection in Older Adults in 2015: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 222 (Supplement_7) ◽  
pp. S577-S583 ◽  
Author(s):  
Ting Shi ◽  
Angeline Denouel ◽  
Anna K Tietjen ◽  
Iain Campbell ◽  
Emily Moran ◽  
...  
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
Developing Countries ◽  
Respiratory Syncytial Virus ◽  
Hospital Admission ◽  
Respiratory Infection ◽  
Acute Respiratory Infection ◽  
Disease Burden ◽  
Hospital Deaths ◽  
Syncytial Virus

AbstractRespiratory syncytial virus–associated acute respiratory infection (RSV-ARI) constitutes a substantial disease burden in older adults aged ≥65 years. We aimed to identify all studies worldwide investigating the disease burden of RSV-ARI in this population. We estimated the community incidence, hospitalization rate, and in-hospital case-fatality ratio (hCFR) of RSV-ARI in older adults, stratified by industrialized and developing regions, using data from a systematic review of studies published between January 1996 and April 2018 and 8 unpublished population-based studies. We applied these rate estimates to population estimates for 2015 to calculate the global and regional burdens in older adults with RSV-ARI in the community and in hospitals for that year. We estimated the number of in-hospital deaths due to RSV-ARI by combining hCFR data with hospital admission estimates from hospital-based studies. In 2015, there were about 1.5 million episodes (95% confidence interval [CI], .3 million–6.9 million) of RSV-ARI in older adults in industrialized countries (data for developing countries were missing), and of these, approximately 14.5% (214 000 episodes; 95% CI, 100 000–459 000) were admitted to hospitals. The global number of hospital admissions for RSV-ARI in older adults was estimated at 336 000 hospitalizations (uncertainty range [UR], 186 000–614 000). We further estimated about 14 000 in-hospital deaths (UR, 5000–50 000) related to RSV-ARI globally. The hospital admission rate and hCFR were higher for those aged ≥65 years than for those aged 50–64 years. The disease burden of RSV-ARI among older adults is substantial, with limited data from developing countries. Appropriate prevention and management strategies are needed to reduce this burden.

scholarly journals Global and Regional Burden of Hospital Admissions for Pneumonia in Older Adults: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 222 (Supplement_7) ◽  
pp. S570-S576 ◽  
Author(s):  
Ting Shi ◽  
Angeline Denouel ◽  
Anna K Tietjen ◽  
Jen Wei Lee ◽  
Ann R Falsey ◽  
...  
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
Hospital Admission ◽  
Disease Burden ◽  
Hospital Admissions ◽  
Case Fatality ◽  
Admission Rate ◽  
Case Definition ◽  
Hospital Admission Rate ◽  
Hospital Deaths

AbstractPneumonia constitutes a substantial disease burden among adults overall and those who are elderly. We aimed to identify all studies investigating the disease burden among older adults (age, ≥65 years) admitted to the hospital with pneumonia. We estimated the hospital admission rate and in-hospital case-fatality ratio (CFR) of pneumonia in older adults, stratified by age and economic status (industrialized vs developing), with data from a systematic review of studies published from 1996 through 2017 and from 8 unpublished population-based studies. We applied these rate estimates to population estimates for 2015 to calculate the global and regional burden in older adults who would have been admitted to the hospital with pneumonia that year. We estimated the number of in-hospital pneumonia deaths by combining in-hospital CFRs with hospital admission estimates from hospital-based studies. We identified 109 eligible studies; 73 used clinical pneumonia as the case definition, and 36 used radiologically confirmed pneumonia as the case definition. We estimated that, in 2015, 6.8 million episodes (uncertainty range [UR], 5.8–8.0 episodes) of clinical pneumonia resulted in hospital admissions of older adults worldwide. The hospital admission rate increased with advancing age and was higher in men. The total disease burden was likely underestimated when using the definition of radiologically confirmed pneumonia. Based on data from 52 hospital studies reporting data on pneumonia mortality, we estimated that about 1.1 million in-hospital deaths (UR, 0.9–1.4 in-hospital deaths) occurred among older adults. The burden of pneumonia requiring hospitalization among older adults is substantial. Appropriate prevention and management strategies should be developed to reduce its impact.

scholarly journals Capturing respiratory syncytial virus season in Belgium using the influenza severe acute respiratory infection surveillance network, season 2018/19

2020 ◽  
Vol 25 (39) ◽  
Author(s):  
Lorenzo Subissi ◽  
Nathalie Bossuyt ◽  
Marijke Reynders ◽  
Michèle Gérard ◽  
Nicolas Dauby ◽  
...  
Keyword(s):  
Older Adults ◽  
Respiratory Syncytial Virus ◽  
Respiratory Infection ◽  
Acute Respiratory Infection ◽  
Case Definition ◽  
World Health ◽  
Surveillance Network ◽  
Severe Acute Respiratory Infection ◽  
Respiratory Syncytial Virus Season ◽  
Syncytial Virus

Background Respiratory syncytial virus (RSV) is a common cause of severe respiratory illness in young children (< 5 years old) and older adults (≥ 65 years old) leading the World Health Organization (WHO) to recommend the implementation of a dedicated surveillance in countries. Aim We tested the capacity of the severe acute respiratory infection (SARI) hospital network to contribute to RSV surveillance in Belgium. Methods During the 2018/19 influenza season, we started the SARI surveillance for influenza in Belgium in week 40, earlier than in the past, to follow RSV activity, which usually precedes influenza virus circulation. While the WHO SARI case definition for influenza normally used by the SARI hospital network was employed, flexibility over the fever criterion was allowed, so patients without fever but meeting the other case definition criteria could be included in the surveillance. Results Between weeks 40 2018 and 2 2019, we received 508 samples from SARI patients. We found an overall RSV detection rate of 62.4% (317/508), with rates varying depending on the age group: 77.6% in children aged < 5 years (253/326) and 34.4% in adults aged ≥ 65 years (44/128). Over 90% of the RSV-positive samples also positive for another tested respiratory virus (80/85) were from children aged < 5 years. Differences were also noted between age groups for symptoms, comorbidities and complications. Conclusion With only marginal modifications in the case definition and the period of surveillance, the Belgian SARI network would be able to substantially contribute to RSV surveillance and burden evaluation in children and older adults, the two groups of particular interest for WHO.

scholarly journals Hospitalization Rate of Respiratory Syncytial Virus associated Acute Lower Respiratory Infection among Young Children in Suzhou, China, 2010-2014

2021 ◽  
Author(s):  
Shaolong Ren ◽  
Ting Shi ◽  
Wei Shan ◽  
Si Shen ◽  
Qinghui Chen ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Young Children ◽  
Respiratory Infection ◽  
Disease Burden ◽  
Estimation Method ◽  
Hospitalization Rate ◽  
Acute Lower Respiratory Infection ◽  
Lower Respiratory Infection ◽  
Treatment Data ◽  
Syncytial Virus

Background: Data on disease burden of respiratory syncytial virus (RSV) associated acute lower respiratory infection (ALRI) among young children are limited in China. This study aimed to estimate the hospitalization rate of RSV-associated ALRI (RSV-ALRI) among children aged 0~59 months in Suzhou, China. Methods: We retrospectively identified all hospitalized ALRI children aged 0~59 months in Suzhou University Affiliated Children’s Hospital during January 2010 to December 2014. Detailed diagnosis and treatment data were collected by individual medical chart review. Referring to WHO influenza disease burden estimation method, we estimated the hospitalization rate of RSV-ALRI among children aged 0~59 months in Suzhou, China. Results: Among 28,209 ALRI cases, 19,317 (68.5%) were tested for RSV and the RSV positive proportion was 21.3% (4,107/19,317). The average hospitalization rate of RSV-ALRI for children aged 0~59 months was 14 (95% confidence interval [CI]:14~14)/1,000 children-years, for children aged 0~5, 6~11, 12~23, and 24~59 months were 70 (95%CI: 67~73), 31 (95%CI: 29~33), 11 (95%CI: 10~12), and 3 (95%CI: 3~3) /1,000 children-years, respectively. Conclusion: There is considerable RSV-ALRI hospitalization among children aged 0~59 months, particularly among children aged <1 years. An effective monoclonal antibody or vaccine is urgently needed to address the substantial hospitalization burden owing to RSV infection. Key words: Respiratory syncytial virus, Hospitalization rate, Acute lower respiratory infection, Children, China

scholarly journals Impact of hygienic and social distancing measures against SARS-CoV-2 on respiratory infections caused by other viruses

2021 ◽  
Author(s):  
Jordi Reina ◽  
◽  
Ricardo M. Arcay ◽  
María Busquets ◽  
Herminia Machado
Keyword(s):  
Respiratory Syncytial Virus ◽  
Respiratory Infection ◽  
Acute Respiratory Infection ◽  
Respiratory Infections ◽  
Respiratory Viruses ◽  
Contact Material ◽  
Rt Pcr ◽  
Social Distancing ◽  
Syncytial Virus ◽  
The Impact

Introduction. To control the pandemic caused by SARS-CoV-2, the implementation of social and hygienic confinement measures was determined in all countries. These measures reduce the circulation of most respiratory viruses that are transmitted preferentially by air and contact. Material and methods. The impact of these measures on non-Covid respiratory viruses during the period August-December 2020 and 2019 has been comparatively analyzed. To all nasopharyngeal aspirates that were negative against SARS-CoV-2 by RT-PCR and the suspicion of acute respiratory infection persisted, were subjected to a new RT-PCR that simultaneously and differentially amplifies 21 different respiratory viruses. Results. In the year of the pandemic, a 36.6% decrease was detected in the number of respiratory samples studied and 66% in their positivity in relation to 2019. All viruses showed reduction percentages of between 40-100%. The only viruses that circulated during and after national lockdown were rhinovirus (74.1%), adenovirus (10.1%), and enterovirus (9.6%). Conclusion. The measures used to control the SARS-CoV-2 infection have also affected the community circulation of most respiratory viruses including influenza and respiratory syncytial virus.

scholarly journals Respiratory syncytial virus infection among young children with acute respiratory tract infection in Iraq

1999 ◽  
Vol 5 (5) ◽  
pp. 941-948
Author(s):  
K. A. Albargish ◽  
H. J. Hasony
Keyword(s):  
Respiratory Syncytial Virus ◽  
Virus Infection ◽  
Respiratory Infection ◽  
Respiratory Syncytial Virus Infection ◽  
Acute Respiratory Infection ◽  
Acute Respiratory Tract Infection ◽  
Control Group ◽  
Severe Acute Respiratory Infection ◽  
Syncytial Virus ◽  
Children Under 5

The incidence of respiratory syncytial virus infection was assessed among 516 children under 5 years with acute respiratory infection and 57 control children free of respiratory infection to determine its relation to epidemiological variables. Respiratory syncytial virus was detected in 188 [37.6%]children with acute respiratory infection and in none of the control group. The infection was highest in those with severe acute respiratory infection, particularly severe bronchiolitis and pneumonia and it precipitated acute bronchial asthma in children over 2 years. The infection was most common in the first 6 months and both sexes were equally affected. Socioeconomic factors and crowding played no significant role in the incidence and spread of the infection. Breastfeeding had no clear protective effect against the infection

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