scholarly journals Expression of IL-10 receptors on epithelial cells from the murine small and large intestine

2000 ◽  
Vol 12 (2) ◽  
pp. 133-139 ◽  
Author(s):  
Timothy L. Denning ◽  
Nicola A. Campbell ◽  
Fei Song ◽  
Roberto P. Garofalo ◽  
Gary R. Klimpel ◽  
...  
1998 ◽  
Vol 274 (1) ◽  
pp. G122-G130 ◽  
Author(s):  
Naibedya Chattopadhyay ◽  
Ivan Cheng ◽  
Kimberly Rogers ◽  
Daniela Riccardi ◽  
Amy Hall ◽  
...  

The extracellular calcium ([Formula: see text])-sensing receptor (CaR) plays vital roles in [Formula: see text] homeostasis, but no data are available on its expression in small and large intestine. Polymerase chain reaction products amplified from reverse-transcribed duodenal RNA using CaR-specific primers showed >99% homology with the rat kidney CaR. Northern analysis with a CaR-specific cRNA probe demonstrated 4.1- and 7.5-kb transcripts in all intestinal segments. Immunohistochemistry with CaR-specific antisera showed clear basal staining of epithelial cells of small intestinal villi and crypts and modest apical staining of the former, whereas there was both basal and apical staining of colonic crypt epithelial cells. In situ hybridization and immunohistochemistry also demonstrated CaR expression in Auerbach’s myenteric plexus of small and large intestines and in the submucosa in the region of Meissner’s plexus. Our results reveal CaR expression in several cell types of small and large intestine, in which it may modulate absorptive and/or secretomotor functions.


Alcohol ◽  
2014 ◽  
Vol 48 (7) ◽  
pp. 730
Author(s):  
A.M. Hammer ◽  
J.L. Rendon ◽  
X. Li ◽  
N.L. Morris ◽  
Z.M. Earley ◽  
...  

2015 ◽  
Vol 65 (3-4) ◽  
pp. 287-298
Author(s):  
Mehmet E. Akbalik ◽  
Hakan Sagsoz ◽  
Serkan Erdogan

The intestinal mucosa is under continuous attack of microorganisms and is defended by the joint action of epithelial cells and specialized immune cells. Osteopontin (OPN), a member of the Small Integrin-Binding Ligand, N-linked Glycoprotein (SIBLING) family, is an adhesive phosphorylated glyco-protein that is synthesized by a variety of nonimmune and immune cells that is involved in interactions with cells mediating signaling. OPN is especially required for the maintenance of the epithelial barrier. To gain a better understanding of the biology of OPN, in the avian intestinal tract, we examined subcellular localization of OPN in the small and large intestine using immunohistochemistry. Immunostaining for OPN was prominently and significantly detected in the epithelial cells of the small and large intestine. However, intestinal stromal cells of the small intestine and the smooth muscle cells in the wall of the large intestine did not exhibit OPN immunoreactivity. Our results show that the differences between the localizations of OPN in the chukar partridge’s small and large intestine may be associated with functional differences of intestine parts. Therefore, the expression of OPN in the chukar partridge intestine may play a crucial role in barrier function, host defence, and/or secretion.


1995 ◽  
Vol 270 (20) ◽  
pp. 12162-12169 ◽  
Author(s):  
Sandrine Rubio ◽  
Thierry Lacaze-Masmonteil ◽  
Bernadette Chailley-Heu ◽  
Axel Kahn ◽  
Jacques R. Bourbon ◽  
...  

1961 ◽  
Vol 41 (5) ◽  
pp. 500-504 ◽  
Author(s):  
N. Cordero ◽  
T. Hastings Wilson

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2325
Author(s):  
Yolanda Ber ◽  
Santiago García-Lopez ◽  
Carla J. Gargallo-Puyuelo ◽  
Fernando Gomollón

The small intestine is key in the digestion and absorption of macro and micronutrients. The large intestine is essential for the absorption of water, to allow adequate defecation, and to harbor intestinal microbiota, for which their nutritional role is as important as it is unknown. This article will describe the causes and consequences of malnutrition in patients with inflammatory bowel diseases, the importance of screening and replacement of micronutrient deficits, and the main indications for enteral and parenteral nutrition in these patients. We will also discuss the causes of short bowel syndrome, a complex entity due to anatomical or functional loss of part of the small bowel, which can cause insufficient absorption of liquid, electrolytes, and nutrients and lead to complex management. Finally, we will review the causes, consequences, and management of malnutrition in patients with malignant and benign digestive tumors, including neuroendocrine tumors (present not only in the intestine but also in the pancreas).


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