Demonstration of the target molecule of a protective IgE antibody in secretory glands of Schistosoma japonicum larvae

1994 ◽  
Vol 6 (7) ◽  
pp. 963-971 ◽  
Author(s):  
Takeshi Nara ◽  
Naoki Matsumoto ◽  
Tuenta Janecharut ◽  
Hajime Matsuda ◽  
Kazuo Yamamoto ◽  
...  
Keyword(s):  
Schistosoma Japonicum ◽  
Target Molecule ◽  
Ige Antibody ◽  
Secretory Glands

Schistosoma japonicum: immunolocalization of paramyosin during development

Parasitology ◽  
1997 ◽  
Vol 114 (1) ◽  
pp. 45-52 ◽  
Author(s):  
G. N. GOBERT ◽  
D. J. STENZEL ◽  
M. K. JONES ◽  
D. E. ALLEN ◽  
D. P. McMANUS
Keyword(s):  
Electron Microscopy ◽  
Schistosoma Japonicum ◽  
Polyclonal Antibody ◽  
Developmental Stages ◽  
Muscle Layer ◽  
Protective Properties ◽  
Vaccine Target ◽  
Target Molecule

This paper describes the localization of paramyosin immunoreactivity in Schistosoma japonicum and represents the first comparative immunolocalization study among schistosome adult, cercariae and lung schistosomula by electron microscopy. A polyclonal antibody was utilized to immunolabel paramyosin or paramyosin-like proteins. Paramyosin was localized within the muscle layer of all 3 developmental stages. Furthermore, paramyosin was localized within granules of the post-acetabular glands of cercariae, and within the tegument matrix and surface of lung schistosomules. Adults and cercariae did not display any detectable paramyosin on the surface or within the tegument. The possible functions of paramyosin within S. japonicum and the relevance of these findings in relation to the reported protective properties of paramyosin as an anti-schistosome vaccine target molecule are discussed.

Association between IgE antibody against soluble egg antigen and resistance to reinfection with Schistosoma japonicum

1997 ◽  
Vol 91 (5) ◽  
pp. 606-608 ◽  
Author(s):  
Zhaosong Zhang ◽  
Haiwei Wu ◽  
Suchen Chen ◽  
Lingshen Hu ◽  
Zhangwu Xie ◽  
...  
Keyword(s):  
Schistosoma Japonicum ◽  
Ige Antibody ◽  
Egg Antigen

scholarly journals Role of a mouse monoclonal IgE antibody in passive transfer of immunity to Schistosoma japonicum infection

1987 ◽  
Vol 82 (suppl 4) ◽  
pp. 237-241 ◽  
Author(s):  
Somei Kojima ◽  
Tuenta Janecharut ◽  
Hidekazu Hata ◽  
Munetoshi Niimura
Keyword(s):  
Schistosoma Japonicum ◽  
Passive Transfer ◽  
Ige Antibody

Ultrastructure of Cercarial Tails

1974 ◽  
Vol 32 ◽  
pp. 180-181
Author(s):  
Richard S. Demaree ◽  
Donald M. Wootton
Keyword(s):  
Schistosoma Japonicum ◽  
Intermediate Hosts ◽  
Suitable Host ◽  
Ultrastructural Studies ◽  
Tail Structure

Cercariae (juvenile trematodes with tails) emerge from mollusk intermediate hosts and swim toward definitive hosts or encystment objects. The locomotor power is furnished by the tail. Upon reaching a suitable host or encystment object, the tail is cast off and the cercariae penetrate and/or encyst. Ultrastructural studies of cercariae are sparse. There is even lessUltrastructural studies of cercariae are sparse. There is even less information about the tail structure; and body-to-tail morphology has been documented only for Acanthatrium oregonense and Schistosoma japonicum.

Characterization of mutant ß-Catenin as a target molecule for antigen-specific immunotherapy in Wilms tumors

2004 ◽  
Vol 216 (03) ◽  
Author(s):  
D Ehrlich ◽  
M Thome ◽  
M von Knebel Doeberitz ◽  
R Koesters
Keyword(s):  
Specific Immunotherapy ◽  
Target Molecule

A Short Synthesis of (+)-Brefeldin C via Enantioselective Radical Hydroalkynylation

2019 ◽  
Author(s):  
Lars Gnägi ◽  
Severin Vital Martz ◽  
Daniel Meyer ◽  
Robin Marc Schärer ◽  
Philippe Renaud
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Oxidation State ◽  
Single Step ◽  
Radical Process ◽  
Target Molecule ◽  
Short Synthesis ◽  
The One

<div><div><div><div><p>A very concise total synthesis of (+)-brefeldin C starting from 2-furanylcyclopentene is described. This approach is based on an unprecedented enantioselective radical hydroalkynylation process to introduce the two cyclopentane stereocenters in a single step. The use of a furan substituent allows to achieve a high trans diastereoselectivity during the radical process and it contains the four carbon atoms C1–C4 of the natural product in an oxidation state closely related to the one of the target molecule. The eight-step synthesis require six product purifications and it provides (+)-brefeldin C in 18% overall yield.</p></div></div></div></div>

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