Penetration of clarithromycin and its 14-hydroxy metabolite into middle ear effusion in children with secretory otitis media

1994 ◽  
Vol 33 (2) ◽  
pp. 299-307 ◽  
Author(s):  
Lennart Sundberg ◽  
Åke Cederberg
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Middle Ear Effusion ◽  
Secretory Otitis Media ◽  
Ear Effusion ◽  
Hydroxy Metabolite

Efficacy of medical treatment as an adjunct to surgery in the treatment of secretory otitis media

1986 ◽  
Vol 100 (12) ◽  
pp. 1347-1350 ◽  
Author(s):  
T. H. J. Lesser ◽  
M. I. Clayton ◽  
D. Skinner
Keyword(s):  
Medical Treatment ◽  
Otitis Media ◽  
Middle Ear ◽  
Otitis Media With Effusion ◽  
Randomised Trial ◽  
Control Group ◽  
Middle Ear Effusion ◽  
Secretory Otitis Media ◽  
Ear Effusion

AbstractIn a pilot controlled randomised trial of 38 children who had bilateral secretory otitis media, with effusion demonstrated at operation, we compared the efficacy of a six-week course of an oral decongestant—antihistamine combination and a mucolytic preparation with a control group in preventing the presence of middle-ear effusion six weeks after myringotomy and adenoidectomy. The mucolytic preparation decreased the presence of middle-ear effusion when compared to the decongestant-antihistamine combination and the control group (p=0.06).

Epidemiology of Secretory Otitis Media a Descriptive Cohort Study

1983 ◽  
Vol 92 (2) ◽  
pp. 172-177 ◽  
Author(s):  
M. Fiellau-Nikolajsen
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Spontaneous Recovery ◽  
Average Duration ◽  
Middle Ear Effusion ◽  
Secretory Otitis Media ◽  
Group Population ◽  
Fluctuating Course ◽  
Middle Ear Disease ◽  
Ear Effusion

To determine the prevalence, incidence, and course of secretory otitis media in an age-group population, 404 3-year-old children in a town in Denmark were examined at 6-, 8-, and 12-week intervals over a 6-month period. At each of the four examinations approximately 20% of the children had middle ear effusion (MEE); it was found at least once in 42% of the children, and 6% had persistent effusion at all four examinations. Average duration of MEE was 3 months. Since spontaneous recovery rarely occurred when MEE had been present for more than 3 months, active intervention is recommended after the condition has been followed for this length of time. The highly fluctuating course of MEE demonstrated in early childhood has important implications for concepts in pediatric middle ear disease and treatment.

Presence ofBranhamella catarrhalisalters the survival ofStreptococcus pneumoniaeandHaemophilus influenzaein middle ear effusion: Anin vitrostudy

1989 ◽  
Vol 103 (11) ◽  
pp. 1030-1033 ◽  
Author(s):  
Lars-Eric Stenfors ◽  
Simo Räisänen
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Middle Ear Effusion ◽  
Secretory Otitis Media ◽  
Ear Effusion

AbstractViable and non-viableB. catarrhaliswere mixed together withS. pneumoniaeandH. influenzaeand injected into non-bacterial mucoid effusion material collected from the middle ear of patients with a present secretory otitis media. The samples were incubated at 37°C. Presence of viableB. catarrhaliscould evidently prolong the survival of bothS. pneumoniaeandH. influenzae. Presence of non-viableB. catarrhaliscould also enhance the growth ofS. pneumoniae, but notH. influenzae. In contrast bothS. pneumoniaeandH. influenzaesuppressed the growth ofB. catarrhalis.

Antibacterial Therapy and Middle Ear Effusions

1976 ◽  
Vol 85 (2_suppl) ◽  
pp. 250-253 ◽  
Author(s):  
Paul A. Shurin
Keyword(s):  
Drug Therapy ◽  
Effective Treatment ◽  
Otitis Media ◽  
Middle Ear ◽  
Middle Ear Effusion ◽  
Prolonged Administration ◽  
Antimicrobial Drugs ◽  
Acute Attacks ◽  
Ear Effusion

Antimicrobial drugs chosen for their activity against the causative pathogens of otitis media provide effective treatment for acute attacks. Prolonged administration of some of these agents has recently been shown to be of value in the prevention of symptomatic otitis. The role of drug therapy in the management of chronic or recurrent middle ear effusion is unknown at present.

scholarly journals The management of acute otitis media

1984 ◽  
Vol 22 (14) ◽  
pp. 53-54
Keyword(s):  
Hearing Loss ◽  
Otitis Media ◽  
Clinical Examination ◽  
Middle Ear ◽  
Acute Otitis Media ◽  
Infectious Complications ◽  
Middle Ear Effusion ◽  
Suppurative Otitis Media ◽  
Painful Condition ◽  
Ear Effusion

Acute suppurative otitis media (AOM) is a common, painful condition affecting 20% of children under 4 years at least once a year,1 and perhaps more in infancy when clinical examination is most difficult. Infectious complications such as mastoiditis, meningitis and cerebral abscess are now rare, but chronic middle ear effusion and hearing loss remain common. Hearing loss may persist long after the infective episode,2 and may impair learning.

To Tube or Not to Tube: That Continues to Be the Question

PEDIATRICS ◽  
1985 ◽  
Vol 76 (2) ◽  
pp. 332-332
Author(s):  
DAVID W. TEELE ◽  
BERNARD ROSNER ◽  
JEROME O. KLEIN
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Otitis Media With Effusion ◽  
Middle Ear Effusion ◽  
Speech And Language ◽  
Clinically Significant ◽  
Ear Effusion

In Reply.— We appreciate Chamberlin's thoughtful comments about the associations between otitis media with effusion and development of speech and language and his concern about results that are statistically significant but may not be "clinically significant." We share his view that measurements of the sequelae of disease should include those that are meaningful to the child. We reported results of tests of speech and language that indicated that children who had spent many days with middle ear effusion during the first years of life scored significantly lower than did children who had not spent such time.

Role of Tonsillectomy and Adenoidectomy in the Management of Children with Middle Ear Effusion

1980 ◽  
Vol 89 (5_suppl) ◽  
pp. 43-46 ◽  
Author(s):  
James B. Snow
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Clinical Effectiveness ◽  
First Year ◽  
Middle Ear Effusion ◽  
Beneficial Effects ◽  
Per Se ◽  
Second Year ◽  
Ear Effusion

Evidence for the clinical effectiveness of adenoidectomy or tonsillectomy and adenoidectomy in the management of children with persistent middle ear effusions is incomplete and what evidence there is in the literature is not convincing. In the first year after tonsillectomy and adenoidectomy there is less otitis media. The beneficial effects of tonsillectomy and adenoidectomy on the incidence of otitis media declines in the second year after the operation. The prevailing opinion is that adenoidectomy is not indicated in the vast majority of children in whom a middle ear effusion has persisted for six weeks or more in spite of antibiotic therapy. Factors favoring an adenoidectomy would be persistent nasal obstruction, persistent purulent rhinorrhea and persistent adenoiditis. The role of tonsillectomy is even less clear, but the decision regarding tonsillectomy is made by most clinicians on the basis of the amount of intercurrent or chronic tonsillitis rather than on the basis of the middle ear effusion per se.

scholarly journals Experimental Otitis Media With Effusion Induced by Middle Ear Effusion

1992 ◽  
Vol 102 (9) ◽  
pp. 1037???1042 ◽  
Author(s):  
Junko Nakata ◽  
Masashi Suzuki ◽  
Hideyuki Kawauchi ◽  
Goro Mogi
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Otitis Media With Effusion ◽  
Middle Ear Effusion ◽  
Ear Effusion
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