scholarly journals 231 Structure and mechanism of CRISPR/Cas9

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 56-57
Author(s):  
David W Taylor

Abstract Recent advances in genome editing using CRISPR-Cas9 and related technologies have revolutionized the ability to manipulate genes in a rapid, precise, and flexible manner. These advances have spurred an explosion of interest in the possible ways in which genome editing can improve human health. I will provide an overview of CRISPR-Cas systems, the structure and function of CRISPR-Cas9, and the repurposing of CRISPR-Cas9 for genome engineering.

2013 ◽  
Vol 448-453 ◽  
pp. 529-531
Author(s):  
Jing Bo Zhao ◽  
Li Bo Hao

Analysis of the causes of dust brick and tile production enterprises, from the impact on human health, the factory machinery and equipment wear, impact on environment protection, expounds the harmfulness of dust, and discusses the type, structure and function of the filter, as well as the precipitator combined use method and way to control dust.


Diabetes ◽  
1994 ◽  
Vol 43 (8) ◽  
pp. 955-959 ◽  
Author(s):  
J Mark Petrash ◽  
Ivan Tarle ◽  
David K Wilson ◽  
Florante A Quiocho

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 1824 ◽  
Author(s):  
Brigitte Schönberger ◽  
Christoph Schaal ◽  
Richard Schäfer ◽  
Björn Voß

Tight regulation of cellular processes is key to the development of complex organisms but also vital for simpler ones. During evolution, different regulatory systems have emerged, among them RNA-based regulation that is carried out mainly by intramolecular and intermolecular RNA–RNA interactions. However, methods for the transcriptome-wide detection of these interactions were long unavailable. Recently, three publications described high-throughput methods to directly detect RNA duplexes in living cells. This promises to enable in-depth studies of RNA-based regulation and will narrow the gaps in our understanding of RNA structure and function. In this review, we highlight the benefits of these methods and their commonalities and differences and, in particular, point to methodological shortcomings that hamper their wider application. We conclude by presenting ideas for how to overcome these problems and commenting on the prospects we see in this area of research.


Biochimie ◽  
1989 ◽  
Vol 71 (2) ◽  
pp. 195-209 ◽  
Author(s):  
Yves Malthiéry ◽  
Claudine Marriq ◽  
Jean-Louis Bergé-Lefranc ◽  
Jean-Louis Franc ◽  
Mireille Henry ◽  
...  

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