scholarly journals Editorial for “Accuracy of Preoperative Breast MRI Versus Conventional Imaging in Measuring Pathological Extent of Invasive Lobular Carcinoma”

2021 ◽  
Author(s):  
Lars J Grimm
Keyword(s):  
Invasive Lobular Carcinoma ◽  
Lobular Carcinoma ◽  
Breast Mri ◽  
Conventional Imaging ◽  
Preoperative Breast Mri

scholarly journals Accuracy of Preoperative Breast MRI versus Conventional Imaging in Measuring Pathologic Extent of Invasive Lobular Carcinoma

2021 ◽  
Author(s):  
Keegan K Hovis ◽  
Janie M Lee ◽  
Daniel S Hippe ◽  
Hannah Linden ◽  
Meghan R Flanagan ◽  
...  
Keyword(s):  
Invasive Lobular Carcinoma ◽  
Lobular Carcinoma ◽  
Intraclass Correlation ◽  
Breast Mri ◽  
Absolute Difference ◽  
Difference Threshold ◽  
Conventional Imaging ◽  
Mean Absolute Difference ◽  
Younger Women ◽  
Preoperative Breast Mri

Abstract Objective To determine whether invasive lobular carcinoma (ILC) extent is more accurately depicted with preoperative MRI (pMRI) than conventional imaging (mammography and/or ultrasound). Methods After IRB approval, we retrospectively identified women with pMRIs (February 2005 to January 2014) to evaluate pure ILC excluding those with ipsilateral pMRI BI-RADS 4 or 5 findings or who had neoadjuvant chemotherapy. Agreement between imaging and pathology sizes was summarized using Bland-Altman plots, absolute and percent differences, and the intraclass correlation coefficient (ICC). Rates of underestimation and overestimation were evaluated and their associations with clinical features were explored. Results Among the 56 women included, pMRI demonstrated better agreement with pathology than conventional imaging by mean absolute difference (1.6 mm versus −7.8 mm, P < 0.001), percent difference (10.3% versus −16.4%, P < 0.001), and ICC (0.88 versus 0.61, P = 0.019). Conventional imaging more frequently underestimated ILC span than pMRI using a 5 mm difference threshold (24/56 (43%) versus 10/56 (18%), P < 0.001), a 25% threshold (19/53 (36%) versus 10/53 (19%), P = 0.035), and T category change (17/56 (30%) versus 7/56 (13%), P = 0.006). Imaging–pathology size concordance was greater for MRI-described solitary masses than other lesion types for both MRI and conventional imaging (P < 0.05). Variability of conventional imaging was lower for patients ≥ to the median age of 62 years than for patients younger than the median age (SD: 12 mm versus 22 mm, P = 0.012). Conclusion MRI depicts the size of pure ILC more accurately than conventional imaging and may have particular value for younger women.

scholarly journals The Impact of Preoperative Breast Magnetic Resonance Imaging on Surgical Management in Symptomatic Patients With Invasive Lobular Carcinoma

2020 ◽  
Vol 14 ◽  
pp. 117822342094847
Author(s):  
Brian M Moloney ◽  
Peter F McAnena ◽  
Éanna J Ryan ◽  
Ellen O Beirn ◽  
Ronan M Waldron ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Lobular Carcinoma ◽  
Multivariable Analysis ◽  
Breast Mri ◽  
Breast Conserving Surgery ◽  
Conventional Imaging ◽  
Resonance Imaging ◽  
Tertiary Centre ◽  
The Impact

Objective: Due to an insidious proliferative pattern, invasive lobular breast cancer (ILC) often fails to form a defined radiological or palpable lesion and accurate diagnosis remains challenging. This study aimed to determine the value of preoperative magnetic resonance imaging (MRI) for ILC and its impact on surgical outcomes. Methods: Consecutive symptomatic patients diagnosed with ILC in a tertiary centre over a 9-year period were reviewed. The time from diagnosis until surgery, initial type of surgery/index operation (breast-conserving surgery [BCS]/mastectomy) and the rates of reoperation (re-excision/completion mastectomy) were recorded. Patients were grouped into those who received conventional imaging and preoperative MRI (MR+) and those who received conventional imaging alone (MR–). Results: There were 218 cases of ILC, and 32.1% (n = 70) had preoperative MRI. Time from diagnosis to surgery was longer in the MR+ than the MR– group (32.5 vs 21.1 days, P < .001) even when adjusting for age and breast density. Initial BCS was performed on 71.4% (n = 50) of MR+ patients and 72.3% (n = 107) of the MR– group. While the rate of completion mastectomy following initial BCS was higher in the MR+ group (30.0%, n = 15 vs 14.0%, n = 15; χ2 = 5.63; P = .018), this association was not maintained in multivariable analysis. No difference was recorded in overall (initial and completion) mastectomy rate between the MR+ and MR– group (50.0%, n = 35 vs 37.8%, n = 56; χ2 = 2.89; P = .089). Margin re-excision following BCS was comparable between groups (8.0%, n =4, vs 9.3%, n = 10; χ2 = 0.076, P = .783) despite the selection bias for borderline conservable cases in the MR+ group. The rate of usage of MRI for ILC cases declined over the study period. Conclusion: While MRI was associated with minor delays in treatment and did not reduce overall rates of margin re-excision or completion mastectomy, it altered the choice of surgical procedure in almost a quarter of MR+ cases. The benefit of preoperative breast MRI appears to be confined to select (younger, dense breast, borderline conservable) cases in symptomatic ILC.

Breast MRI in Invasive Lobular Carcinoma: A Useful Investigation in Surgical Planning?

2016 ◽  
Vol 22 (2) ◽  
pp. 143-150 ◽  
Author(s):  
Muhammad Asad Parvaiz ◽  
Peiming Yang ◽  
Eisha Razia ◽  
Margaret Mascarenhas ◽  
Caroline Deacon ◽  
...  
Keyword(s):  
Invasive Lobular Carcinoma ◽  
Surgical Planning ◽  
Lobular Carcinoma ◽  
Breast Mri

scholarly journals Invasive lobular carcinoma of the breast: MRI pathological correlation following bilateral total mastectomy

2012 ◽  
Vol 53 (4) ◽  
pp. 367-375 ◽  
Author(s):  
Aude Stivalet ◽  
Alain Luciani ◽  
Frederic Pigneur ◽  
Thu Ha Dao ◽  
Pauline Beaussart ◽  
...  
Keyword(s):  
Invasive Lobular Carcinoma ◽  
Lobular Carcinoma ◽  
Breast Mri ◽  
Total Mastectomy ◽  
Carcinoma Of The Breast ◽  
Pathological Correlation

scholarly journals Impact of preoperative breast MRI on 10-year survival of patients included in the Swedish randomized multicentre POMB trial

BJS Open ◽  
2021 ◽  
Vol 5 (5) ◽  
Author(s):  
V Gonzalez ◽  
B Arver ◽  
L Löfgren ◽  
L Bergkvist ◽  
K Sandelin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Mri ◽  
Control Group ◽  
Conventional Imaging ◽  
Newly Diagnosed ◽  
Control Groups ◽  
Risk Of Death ◽  
Preoperative Breast Mri ◽  
And Control

Abstract Background The value of preoperative breast MRI as an adjunct technique regarding its effect on re-excision rates has been a subject of discussion. No survival data regarding preoperative breast MRI are available from randomized studies. Methods Ten-year follow-up of the POMB randomized multicentre study was analysed, evaluating MRI and its effect on disease-free survival (DFS) and overall survival (OS). Patients with newly diagnosed breast cancer were randomized to either preoperative MRI or conventional imaging. Kaplan–Meier plots were used to analyse DFS and OS, and Cox regression to estimate hazard ratios (HRs). Results A total of 440 patients, aged 56 years or less, with newly diagnosed breast cancer were randomized to either preoperative MRI (220) or conventional imaging (220; control). Median follow-up for each group was 10 years. DFS rates were 85.5 and 80.0 per cent for the MRI and control groups respectively (P = 0.099). The risk of relapse or death was 46 per cent higher in the control group (HR 1.46, 95 per cent c.i. 0.93 to 2.29). OS rates after 10 years were 90.9 and 88.6 per cent in the MRI and control groups respectively (P = 0.427). The risk of death was 27 per cent higher in the control group (HR 1.27, 0.71 to 2.29). Locoregional, distant, and contralateral recurrence outcomes combined were increased in the control group (P = 0.048). A subgroup analysis of patients with breast cancer stages I–III showed that preoperative MRI improved DFS compared with conventional imaging, but this did not reach statistical significance (P = 0.057). Conclusion After 10 years of follow-up, preoperative breast MRI as an adjunct to conventional imaging resulted in slightly, but non-significantly, improved DFS and OS. Registration number: NCT01859936 (http://www.clinicaltrials.gov).

scholarly journals Effectiveness of Breast MRI and18F-FDG PET/CT for the Preoperative Staging of Invasive Lobular Carcinoma versus Ductal Carcinoma

2015 ◽  
Vol 18 (1) ◽  
pp. 63 ◽  
Author(s):  
Na Young Jung ◽  
Sung Hoon Kim ◽  
Sung Hun Kim ◽  
Ye Young Seo ◽  
Jin Kyoung Oh ◽  
...  
Keyword(s):  
Invasive Lobular Carcinoma ◽  
Fdg Pet ◽  
Ductal Carcinoma ◽  
Lobular Carcinoma ◽  
Preoperative Staging ◽  
Breast Mri ◽  
Pet Ct ◽  
Fdg Pet Ct

scholarly journals Amyloidosis of the Breast with Multicentric DCIS and Pleomorphic Invasive Lobular Carcinoma in a Patient with Underlying Extranodal Castleman’s Disease

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
David Chiang ◽  
Michael Lee ◽  
Pauline Germaine ◽  
Lydia Liao
Keyword(s):  
Invasive Lobular Carcinoma ◽  
Ductal Carcinoma ◽  
Lobular Carcinoma ◽  
Castleman’S Disease ◽  
Breast Mri ◽  
Left Breast ◽  
Interesting Case ◽  
Secondary Amyloidosis ◽  
Castleman's Disease ◽  
Magnetic Resonance Imaging Mri

We present an interesting case of focal amyloidosis of the left breast which was intermixed with ductal carcinoma in situ (DCIS). On subsequent staging bilateral breast magnetic resonance imaging (MRI), the patient was found to have an additional suspicious enhancing mass with spiculated borders within the left breast. This mass was biopsy proven to represent pleomorphic invasive lobular carcinoma. A pulmonary nodule within the lingula was also noted on the staging bilateral breast MRI and was biopsy proven to represent extranodal Castleman’s disease. Therefore, it is believed that our patient had secondary amyloidosis due to Castleman’s disease.

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