The Relative Response of Hepatic Lipids in the Rat to Graded Levels of Dietary Myo-Inositol and Other Lipotropes

1980 ◽  
Vol 110 (3) ◽  
pp. 496-504 ◽  
Author(s):  
D. B. Andersen ◽  
B. J. Holub
Author(s):  
Наум Аронович Эпштейн

Представлены формулы для расчета коэффициентов относительной чувствительности RRF (relative response factors) и поправочных коэффициентов F (correction factors) примесей, а также формулы, необходимые для понимания сущности коэффициентов RRF и F. Рассмотрены основные способы определения поправочных коэффициентов и их ограничения (условия, выполнение которых необходимо для корректного определения RRF и F). Эти ограничения не отражены в Европейской фармакопее и в Фармакопее США, но от их учета зависит правильность определения значений поправочных коэффициентов. Приведены примеры и даны рекомендации для надежного определения и правильного использования поправочных коэффициентов.


The author compares the relative response of Treasury fund flows to the sentiment-prone Michigan Survey of Inflation Expectations and to the Blue Chip Survey of Financial Forecasts, a professional forecast of inflation. The Treasury market is an ideal subject for examining whether or not sentiment affects flows: it is highly liquid, making it unlikely that it is hard to arbitrage, and inflation is the primary factor affecting its returns. Using mutual fund inflows into TIPs and Treasury mutual funds that occurred between January 1991 and June 2011, the author finds that the Michigan Survey is insignificantly related to flows into inflation-indexed TIPs and is positively related to flows into nominal Treasury funds. The Blue Chip Survey does not have incremental explanatory power. The evidence is consistent with a combination of a hedging motive and a flight to liquidity triggered by information in the Michigan Survey about households’ perception of financial market risk. The two motives reinforce each other in driving flows into nominal Treasury funds when the Michigan forecast of inflation is high, while they appear to cancel each other out in determining flows into the illiquid TIPS market.


2001 ◽  
Vol 131 (6) ◽  
pp. 1770-1776 ◽  
Author(s):  
Aline Adam ◽  
Marie-Anne Levrat-Verny ◽  
Hubert W. Lopez ◽  
Michel Leuillet ◽  
Christian Demigné ◽  
...  

1969 ◽  
Vol 47 (6) ◽  
pp. 619-630 ◽  
Author(s):  
A. Chalvardjian

To investigate the increase in ratio of C16 to C18 nonessential fatty acids in hepatic triglycerides of choline-deficient rats, two groups of rats fed, respectively, a choline-deficient and a choline-supplemented diet for 3–4 days were injected either with 1-14C-acetate intraperitoneally or with a mixture of 9,10-3H-palmitate and 18-14C-stearate intravenously. The choline-deficient and choline-supplemented rats were killed 3 h after labelled acetate injection. Further groups of choline-deficient and choline-supplemented rats were killed at intervals of 1 min to 6 h after injection with labelled palmitate and stearate. Extracts of lipids from livers and sera were analyzed by gas–liquid and thin-layer chromatography. In the choline-deficient rats injected with 1-14C-acetate the ratio of C16 to C18 labelled fatty acids incorporated into hepatic and serum triglycerides was increased and the ratio of those incorporated into hepatic and serum phospholipids was decreased. The ratio of monounsaturated fatty acids to saturated fatty acids incorporated into the triglycerides and phospholipids of liver and serum of the choline-deficient rats was decreased compared to that of the choline-supplemented rats. Similar differences between the two groups of rats were evident in the hepatic lipids of animals injected with 3H-palmitate and 14C-stearate. The early alteration of the ratios of hepatic nonessential fatty acids suggests that the initial change is a decreased desaturation of fatty acids.


2014 ◽  
Vol 56 (4) ◽  
pp. 443-465 ◽  
Author(s):  
Andrea Vocino ◽  
Michael J. Polonsky

1987 ◽  
Vol 54 (3) ◽  
pp. 389-395 ◽  
Author(s):  
David S. Horne

SummaryThe ethanol (EtOH) stability of skim milk and the stability towards aggregation of casein micelles diluted into ethanolic buffer solutions were compared using data obtained from previously published experiments. Differences in absolute stability and in relative response were observed when Ca2+ level and pH were adjusted, the buffer system results lying below those from skim milk in both cases. Increasing the ionic strength of skim milk adjusted to pH 7·0 lowered its EtOH stability whereas increasing the ionic strength of the diluting buffer increased the stability of the casein micelles. The hypothesis is put forward that the differences are due to the simultaneous precipitation of Ca phosphate when EtOH is added to skim milk. This draws calcium from the caseinate sites of the micelle, counteracting the destabilizing effects of the EtOH towards the micelle. Such removal and the consequent restructuring are kinetically controlled and micellar precipitation in skim milk finally occurs when the micellar coagulation time falls within the time scale of the restructuring reactions.


1967 ◽  
Vol 93 (3) ◽  
pp. 227-233
Author(s):  
Takashi Nakamura ◽  
Shozo Nakamura ◽  
Atsushi Onodera ◽  
Osamu Suzuki ◽  
Tatsuya Aikawa ◽  
...  
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