Mathematical Analysis of the Establishment of Human Peripheral Blood Cell Lines2

1969 ◽  
Keyword(s):  
Blood Cell ◽  
Cell Lines ◽  
Mathematical Analysis ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Peripheral Blood Cell

Hematologic Changes After Total Body Irradiation and Autologous Transplantation of Hematopoietic Peripheral Blood Progenitor Cells in Dogs With Lymphoma

2011 ◽  
Vol 49 (2) ◽  
pp. 341-343 ◽  
Author(s):  
C. Escobar ◽  
C. Grindem ◽  
J. A. Neel ◽  
S. E. Suter
Keyword(s):  
Blood Cell ◽  
Progenitor Cells ◽  
Cell Lines ◽  
Total Body Irradiation ◽  
Peripheral Blood ◽  
Progenitor Cell ◽  
Peripheral Blood Cell ◽  
Peripheral Blood Progenitor Cell ◽  
Cell Transplant ◽  
Total Body

Dogs with and without lymphoma have undergone hematopoietic cell transplantation in a research setting for decades. North Carolina State University is currently treating dogs with B- and T-cell lymphoma in a clinical setting with autologous peripheral blood progenitor cell transplants, using peripheral blood CD34+ progenitor cells harvested using an apheresis machine. Complete blood counts were performed daily for 15 to 19 days posttransplantation to monitor peripheral blood cell nadirs and subsequent CD34+ cell engraftment. This study documents the hematologic toxicities of total body irradiation in 10 dogs and the subsequent recovery of the affected cell lines after peripheral blood progenitor cell transplant, indicating successful CD34+ engraftment. All peripheral blood cell lines, excluding red blood cells, experienced grade 4 toxicities. All dogs had ≥ 500 neutrophils/μl by day 12, while thrombocytopenia persisted for many weeks. All dogs were clinically normal at discharge.

Sign in / Sign up

Export Citation Format

Share Document