Effect of the Retinoic Acid Analog Ro 11-1430 on Proteoglycans of Swarm Rat Chondrosarcoma23

1981 ◽  
Keyword(s):  
Retinoic Acid ◽  
Acid Analog

scholarly journals A novel retinoic acid analog, 4-amino-2-trifluoromethyl-phenyl retinate, inhibits gastric cancer cell growth

2013 ◽  
Vol 33 (2) ◽  
pp. 415-422 ◽  
Author(s):  
KONG-WANG HU ◽  
XIAO-HUA PAN ◽  
FEI-HU CHEN ◽  
RONG QIN ◽  
LI-MING WU ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Retinoic Acid ◽  
Cell Growth ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Cancer Cell Growth ◽  
Acid Analog

The retinoic acid analog CBS-211A potentiates the 1α,25-dihydroxyvitamin D3-induced differentiation of U937 cells

1993 ◽  
Vol 38 (S1) ◽  
pp. 91-99 ◽  
Author(s):  
M. Taimi ◽  
H. Defacque ◽  
T. Commes ◽  
J. Favero ◽  
J. Dornand ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
U937 Cells ◽  
Induced Differentiation ◽  
Dihydroxyvitamin D3 ◽  
Acid Analog

scholarly journals A novel retinoic acid analog, 4-Amino-2-Trifluoromethyl-Phenyl Retinate (ATPR) triggers differentiation and is effective in the treatment of Acute Promyelocytic Leukemia

2020 ◽  
Author(s):  
Jing Bao ◽  
Yan Du ◽  
Lan-lan Li ◽  
Liang Xia ◽  
Fei-hu Chen
Keyword(s):  
Retinoic Acid ◽  
Notch Signaling ◽  
Acute Promyelocytic Leukemia ◽  
Protein Concentration ◽  
Tumor Tissue ◽  
Promyelocytic Leukemia ◽  
Acid Analog ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Pathological Model

AbstractAcute promyelocytic leukemia (APL), form RARα fusion genes and proteins is one of the most prevalent forms of leukemia. 4-Amino-2-Trifluoromethyl-Phenyl Retinate (ATPR), a derivative of all-trans-retinoic acid (ATRA), is of potent functions in the induce of cell differentiation, growth arrest, and apoptosis. Nowadays, we aimed to investigate the therapeutic effect of ATPR on this APL pathological model, and whether the mechanism involves PI3K/AKT, ERK and Notch signaling. We established a human xenograft mouse model using NB4 cells and found that ATPR significantly increased the protein concentration in the CD11b and suppressed the PI3K/AKT signaling and activated the ERK and Notch signaling in tumor tissue. Collectively, these data suggest that ATPR shows antileukemic effects by regulating PI3K/AKT, ERK and Notch signaling.

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