scholarly journals Vitamin D, Calcium Supplementation, and Colorectal Adenomas: Results of a Randomized Trial

2003 ◽  
Vol 95 (23) ◽  
pp. 1765-1771 ◽  
Author(s):  
M. V. Grau
Keyword(s):  
Vitamin D ◽  
Randomized Trial ◽  
Calcium Supplementation ◽  
Colorectal Adenomas

scholarly journals No Evidence for Posttreatment Effects of Vitamin D and Calcium Supplementation on Risk of Colorectal Adenomas in a Randomized Trial

2019 ◽  
Vol 12 (5) ◽  
pp. 295-304 ◽  
Author(s):  
Audrey H. Calderwood ◽  
John A. Baron ◽  
Leila A. Mott ◽  
Dennis J. Ahnen ◽  
Roberd M. Bostick ◽  
...  
Keyword(s):  
Vitamin D ◽  
Randomized Trial ◽  
Calcium Supplementation ◽  
Colorectal Adenomas

scholarly journals No Association Between Vitamin D Supplementation and Risk of Colorectal Adenomas or Serrated Polyps in a Randomized Trial

2021 ◽  
Vol 19 (1) ◽  
pp. 128-135.e6 ◽  
Author(s):  
Mingyang Song ◽  
I-Min Lee ◽  
JoAnn E. Manson ◽  
Julie E. Buring ◽  
Rimma Dushkes ◽  
...  
Keyword(s):  
Vitamin D ◽  
Randomized Trial ◽  
Vitamin D Supplementation ◽  
Colorectal Adenomas ◽  
Serrated Polyps

scholarly journals Prolonged Effect of Calcium Supplementation on Risk of Colorectal Adenomas in a Randomized Trial

2007 ◽  
Vol 99 (2) ◽  
pp. 129-136 ◽  
Author(s):  
Maria V. Grau ◽  
John A. Baron ◽  
Robert S. Sandler ◽  
Kristin Wallace ◽  
Robert W. Haile ◽  
...  
Keyword(s):  
Randomized Trial ◽  
Calcium Supplementation ◽  
Colorectal Adenomas ◽  
Prolonged Effect

scholarly journals Risk of keratinocyte carcinomas with vitamin D and calcium supplementation: a secondary analysis of a randomized clinical trial

2020 ◽  
Vol 112 (6) ◽  
pp. 1532-1539
Author(s):  
Michael N Passarelli ◽  
Margaret R Karagas ◽  
Leila A Mott ◽  
Judy R Rees ◽  
Elizabeth L Barry ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Vitamin D ◽  
Cell Carcinoma ◽  
Randomized Clinical Trial ◽  
Calcium Supplementation ◽  
Secondary Analysis ◽  
Colorectal Adenomas ◽  
Double Blind ◽  
Skin Cancers

ABSTRACT Background It is unknown whether dietary supplementation with vitamin D or calcium prevents keratinocyte carcinomas, also known as nonmelanoma skin cancers. Objectives This study aimed to determine whether daily vitamin D or calcium supplementation alters the risk of basal cell carcinoma (BCC) or invasive cutaneous squamous cell carcinoma (SCC). Methods The Vitamin D/Calcium Polyp Prevention Study is a completed multicenter, double-blind, placebo-controlled, partial 2 × 2 factorial, randomized clinical trial of vitamin D, calcium, or both for the prevention of colorectal adenomas. During 2004–2008, a total of 2259 men and women, 45–75 y of age, recently diagnosed with a colorectal adenoma, were randomly assigned to 1000 IU/d of vitamin D3 or placebo and 1200 mg/d of calcium carbonate or placebo for 3 or 5 y, and followed after treatment ended. Reports of incident BCC or SCC were confirmed from pathology records. Results During a median follow-up of 8 y, 200 (9%) participants were diagnosed with BCC and 68 (3%) participants were diagnosed with SCC. BCC incidence was unrelated to treatment with vitamin D compared with no vitamin D (HR: 0.96; 95% CI: 0.73, 1.26), calcium compared with no calcium (HR: 1.01; 95% CI: 0.74, 1.39), and both agents compared with neither (HR: 0.99; 95% CI: 0.65, 1.51). SCC incidence was unrelated to treatment with vitamin D compared with no vitamin D (HR: 0.79; 95% CI: 0.49, 1.27), but there was suggestive evidence of beneficial treatment effects for calcium compared with no calcium (HR: 0.60; 95% CI: 0.36, 1.01) and both agents compared with neither (HR: 0.42; 95% CI: 0.19, 0.91). Conclusions Calcium alone or in combination with vitamin D may reduce the risk of SCC, but not BCC. This trial was registered at clinicaltrials.gov as NCT00153816.

scholarly journals Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial

2007 ◽  
Vol 85 (6) ◽  
pp. 1586-1591 ◽  
Author(s):  
Joan M Lappe ◽  
Dianne Travers-Gustafson ◽  
K Michael Davies ◽  
Robert R Recker ◽  
Robert P Heaney
Keyword(s):  
Vitamin D ◽  
Cancer Risk ◽  
Randomized Trial ◽  
Calcium Supplementation

Calcium and Vitamin D Supplementation. Myths and Realities with Regard to Cardiovascular Risk

2019 ◽  
Vol 17 (6) ◽  
pp. 610-617 ◽  
Author(s):  
Giovanna Muscogiuri ◽  
Luigi Barrea ◽  
Barbara Altieri ◽  
Carolina Di Somma ◽  
Harjit pal Bhattoa ◽  
...  
Keyword(s):  
Vitamin D ◽  
Side Effects ◽  
Secondary Hyperparathyroidism ◽  
Calcium Supplementation ◽  
Physiological Role ◽  
Bone Diseases ◽  
Current Evidence ◽  
Bone Homeostasis ◽  
Mineral Density ◽  
Muscle Health

Vitamin D and calcium are considered crucial for the treatment of bone diseases. Both vitamin D and calcium contribute to bone homeostasis but also preserve muscle health by reducing the risk of falls and fractures. Low vitamin D concentrations result in secondary hyperparathyroidism and contribute to bone loss, although the development of secondary hyperparathyroidism varies, even in patients with severe vitamin D deficiency. Findings from observational studies have shown controversial results regarding the association between bone mineral density and vitamin D/calcium status, thus sparking a debate regarding optimum concentrations of 25-hydroxyvitamin D and calcium for the best possible skeletal health. Although most of the intervention studies reported a positive effect of supplementation with calcium and vitamin D on bone in patients with osteoporosis, this therapeutic approach has been a matter of debate regarding potential side effects on the cardiovascular (CV) system. Thus, the aim of this review is to consider the current evidence on the physiological role of vitamin D and calcium on bone and muscle health. Moreover, we provide an overview on observational and interventional studies that investigate the effect of vitamin D and calcium supplementation on bone health, also taking into account the possible CV side-effects. We also provide molecular insights on the effect of calcium plus vitamin D on the CV system.

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