scholarly journals RE: Physical Activity and the Risk of Liver Cancer: A Systematic Review and Meta-Analysis of Prospective Studies and a Bias Analysis

2019 ◽  
Vol 112 (6) ◽  
pp. 651-652
Author(s):  
Haiyan Yang ◽  
Li Shi ◽  
Ying Wang ◽  
Guangcai Duan ◽  
Yadong Wang
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Liver Cancer ◽  
Prospective Studies ◽  
Meta Analysis ◽  
Bias Analysis

scholarly journals Physical Activity and the Risk of Liver Cancer: A Systematic Review and Meta-Analysis of Prospective Studies and a Bias Analysis

2019 ◽  
Vol 111 (11) ◽  
pp. 1142-1151 ◽  
Author(s):  
Sebastian E Baumeister ◽  
Michael F Leitzmann ◽  
Jakob Linseisen ◽  
Sabrina Schlesinger
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Liver Cancer ◽  
Prospective Studies ◽  
Meta Analysis ◽  
Hazard Ratio ◽  
Bias Analysis ◽  
Liver Cancers ◽  
Selection Variable ◽  
The Mean

Abstract Background Physical inactivity is an established risk factor for several cancers of the digestive system and female reproductive organs, but the evidence for liver cancers is less conclusive. Methods The aim of this study was to synthesize prospective observational studies on the association of physical activity and liver cancer risk by means of a systematic review and meta-analysis. We searched Medline, Embase, and Scopus from inception to January 2019 for prospective studies investigating the association of physical activity and liver cancer risk. We calculated mean hazard ratios (HRs) and 95% confidence intervals (CIs) using a random-effects model. We quantified the extent to which an unmeasured confounder or an unaccounted selection variable could shift the mean hazard ratio to the null. Results Fourteen prospective studies, including 6,440 liver cancers, were included in the systematic review and meta-analysis. The mean hazard ratio for high compared with low physical activity was 0.75 (95% CI = 0.63 to 0.89; 95% prediction interval = 0.52 to 1.07; I² = 64.2%). We estimated that 67.6% (95% CI = 56.6% to 78.5%) of all true effect estimates would have a hazard ratio less than 0.8. Bias analysis suggested than an unobserved confounder would have to be associated with a 1.99-fold increase in the risk of physical activity or liver cancer to explain away the observed mean hazard ratio. An unaccounted for selection variable would have to be related to exposure and endpoint with a relative risk of 1.58 to explain away the mean hazard ratio. Conclusions Physical activity is inversely related to the risk of liver cancer. Further studies with objectively measured physical activity and quasi-experimental designs addressing confounding are needed.

scholarly journals Does physical activity reduce the risk of psychosis? A systematic review and meta-analysis of prospective studies

2020 ◽  
Vol 284 ◽  
pp. 112675 ◽  
Author(s):  
Luisa Leonie Brokmeier ◽  
Joseph Firth ◽  
Davy Vancampfort ◽  
Lee Smith ◽  
Jeroen Deenik ◽  
...  
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Prospective Studies ◽  
Meta Analysis

scholarly journals Body mass index and physical activity and the risk of diverticular disease: a systematic review and meta-analysis of prospective studies

2017 ◽  
Vol 56 (8) ◽  
pp. 2423-2438 ◽  
Author(s):  
Dagfinn Aune ◽  
Abhijit Sen ◽  
Michael F. Leitzmann ◽  
Teresa Norat ◽  
Serena Tonstad ◽  
...  
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Body Mass Index ◽  
Diverticular Disease ◽  
Body Mass ◽  
Prospective Studies ◽  
Meta Analysis

scholarly journals Dietary Fats, Serum Cholesterol and Liver Cancer Risk: A Systematic Review and Meta-Analysis of Prospective Studies

Cancers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1580
Author(s):  
Longgang Zhao ◽  
Chuanjie Deng ◽  
Zijin Lin ◽  
Edward Giovannucci ◽  
Xuehong Zhang
Keyword(s):  
Systematic Review ◽  
Liver Cancer ◽  
Cancer Risk ◽  
Serum Cholesterol ◽  
Dose Response ◽  
Prospective Studies ◽  
Meta Analysis ◽  
Serum Levels ◽  
Dietary Fats ◽  
Inverse Association

To quantify the associations between dietary fats and their major components, as well as serum levels of cholesterol, and liver cancer risk, we performed a systematic review and meta-analysis of prospective studies. We searched PubMed, Embase, and Web of Science up to October 2020 for prospective studies that reported the risk estimates of dietary fats and serum cholesterol for liver cancer risk. We carried out highest versus lowest intake or level and dose-response analyses. Higher intake of dietary saturated fatty acids (SFA) was associated with a higher liver cancer risk in both category analysis (relative risk [RR]highest vs. lowest intake = 1.34, 95% confidence interval [CI]: 1.06, 1.69) and dose-response analysis (RR1% energy = 1.04, 95%CI: 1.01, 1.07). Higher serum total cholesterol was inversely associated with liver cancer but with large between-studies variability (RR1 mmol/L = 0.72, 95%CI: 0.69, 0.75, I2 = 75.3%). The inverse association was more pronounced for serum high-density lipoprotein (HDL) cholesterol (RR1 mmol/L = 0.42, 95%CI: 0.27, 0.64). Higher intake of dietary SFA was associated with higher risk of liver cancer while higher serum levels of cholesterol and HDL were associated with a lower risk of liver cancer with high between-studies variability.

scholarly journals Alcohol and liver cancer: a systematic review and meta-analysis of prospective studies

2014 ◽  
Vol 25 (8) ◽  
pp. 1526-1535 ◽  
Author(s):  
F. Turati ◽  
C. Galeone ◽  
M. Rota ◽  
C. Pelucchi ◽  
E. Negri ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Cancer ◽  
Prospective Studies ◽  
Meta Analysis

scholarly journals Blood glucose concentration and risk of liver cancer: systematic review and meta-analysis of prospective studies

Oncotarget ◽  
2017 ◽  
Vol 8 (30) ◽  
pp. 50164-50173 ◽  
Author(s):  
Hedong Han ◽  
Tianyi Zhang ◽  
Zhichao Jin ◽  
Honglei Guo ◽  
Xin Wei ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Glucose ◽  
Liver Cancer ◽  
Prospective Studies ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Meta Analysis

scholarly journals Physical activity and the risk of abdominal aortic aneurysm: a systematic review and meta-analysis of prospective studies

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Dagfinn Aune ◽  
Abhijit Sen ◽  
Elsa Kobeissi ◽  
Mark Hamer ◽  
Teresa Norat ◽  
...  
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Prospective Studies ◽  
Meta Analysis ◽  
Activity Level ◽  
Adjusted Relative Risk ◽  
Metabolic Equivalent ◽  
Abdominal Aortic

AbstractThe association between physical activity and risk of abdominal aortic aneurysm has been inconsistent with some studies reporting a reduced risk while others have found no association. We conducted a systematic review and meta-analysis of prospective studies to quantify the association. PubMed and Embase databases were searched up to 3 October 2020. Prospective studies were included if they reported adjusted relative risk (RR) estimates and 95% confidence intervals (CIs) of abdominal aortic aneurysm associated with physical activity. Summary RRs (95% CIs) were estimated using a random effects model. Nine prospective studies (2073 cases, 409,732 participants) were included. The summary RR for high vs. low physical activity was 0.70 (95% CI: 0.56–0.87, I2 = 58%) and per 20 metabolic equivalent task (MET)-hours/week increase of activity was 0.84 (95% CI: 0.74–0.95, I2 = 59%, n = 6). Although the test for nonlinearity was not significant (p = 0.09) the association appeared to be stronger when increasing the physical activity level from 0 to around 20–25 MET-hours/week than at higher levels. The current meta-analysis suggest that higher physical activity may reduce the risk of abdominal aortic aneurysm, however, further studies are needed to clarify the dose–response relationship between different subtypes and intensities of activity and abdominal aortic aneurysm risk.

Sign in / Sign up

Export Citation Format

Share Document