Alcohol and liver cancer: a systematic review and meta-analysis of prospective studies

To quantify the associations between dietary fats and their major components, as well as serum levels of cholesterol, and liver cancer risk, we performed a systematic review and meta-analysis of prospective studies. We searched PubMed, Embase, and Web of Science up to October 2020 for prospective studies that reported the risk estimates of dietary fats and serum cholesterol for liver cancer risk. We carried out highest versus lowest intake or level and dose-response analyses. Higher intake of dietary saturated fatty acids (SFA) was associated with a higher liver cancer risk in both category analysis (relative risk [RR]highest vs. lowest intake = 1.34, 95% confidence interval [CI]: 1.06, 1.69) and dose-response analysis (RR1% energy = 1.04, 95%CI: 1.01, 1.07). Higher serum total cholesterol was inversely associated with liver cancer but with large between-studies variability (RR1 mmol/L = 0.72, 95%CI: 0.69, 0.75, I2 = 75.3%). The inverse association was more pronounced for serum high-density lipoprotein (HDL) cholesterol (RR1 mmol/L = 0.42, 95%CI: 0.27, 0.64). Higher intake of dietary SFA was associated with higher risk of liver cancer while higher serum levels of cholesterol and HDL were associated with a lower risk of liver cancer with high between-studies variability.

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Physical Activity and the Risk of Liver Cancer: A Systematic Review and Meta-Analysis of Prospective Studies and a Bias Analysis

JNCI Journal of the National Cancer Institute ◽

10.1093/jnci/djz111 ◽

2019 ◽

Vol 111 (11) ◽

pp. 1142-1151 ◽

Cited By ~ 7

Author(s):

Sebastian E Baumeister ◽

Michael F Leitzmann ◽

Jakob Linseisen ◽

Sabrina Schlesinger

Keyword(s):

Physical Activity ◽

Systematic Review ◽

Liver Cancer ◽

Prospective Studies ◽

Meta Analysis ◽

Hazard Ratio ◽

Bias Analysis ◽

Liver Cancers ◽

Selection Variable ◽

The Mean

Abstract Background Physical inactivity is an established risk factor for several cancers of the digestive system and female reproductive organs, but the evidence for liver cancers is less conclusive. Methods The aim of this study was to synthesize prospective observational studies on the association of physical activity and liver cancer risk by means of a systematic review and meta-analysis. We searched Medline, Embase, and Scopus from inception to January 2019 for prospective studies investigating the association of physical activity and liver cancer risk. We calculated mean hazard ratios (HRs) and 95% confidence intervals (CIs) using a random-effects model. We quantified the extent to which an unmeasured confounder or an unaccounted selection variable could shift the mean hazard ratio to the null. Results Fourteen prospective studies, including 6,440 liver cancers, were included in the systematic review and meta-analysis. The mean hazard ratio for high compared with low physical activity was 0.75 (95% CI = 0.63 to 0.89; 95% prediction interval = 0.52 to 1.07; I² = 64.2%). We estimated that 67.6% (95% CI = 56.6% to 78.5%) of all true effect estimates would have a hazard ratio less than 0.8. Bias analysis suggested than an unobserved confounder would have to be associated with a 1.99-fold increase in the risk of physical activity or liver cancer to explain away the observed mean hazard ratio. An unaccounted for selection variable would have to be related to exposure and endpoint with a relative risk of 1.58 to explain away the mean hazard ratio. Conclusions Physical activity is inversely related to the risk of liver cancer. Further studies with objectively measured physical activity and quasi-experimental designs addressing confounding are needed.

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Blood glucose concentration and risk of liver cancer: systematic review and meta-analysis of prospective studies

Oncotarget ◽

10.18632/oncotarget.16816 ◽

2017 ◽

Vol 8 (30) ◽

pp. 50164-50173 ◽

Cited By ~ 4

Author(s):

Hedong Han ◽

Tianyi Zhang ◽

Zhichao Jin ◽

Honglei Guo ◽

Xin Wei ◽

...

Keyword(s):

Systematic Review ◽

Blood Glucose ◽

Liver Cancer ◽

Prospective Studies ◽

Glucose Concentration ◽

Blood Glucose Concentration ◽

Meta Analysis

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Oligorecurrent Prostate Cancer and Stereotactic Body Radiotherapy: Where Are We Now? A Systematic Review and Meta-analysis of Prospective Studies

European Urology Open Science ◽

10.1016/j.euros.2021.02.008 ◽

2021 ◽

Vol 27 ◽

pp. 19-28

Author(s):

Giulia Marvaso ◽

Stefania Volpe ◽

Matteo Pepa ◽

Matteo Augugliaro ◽

Giulia Corrao ◽

...

Keyword(s):

Prostate Cancer ◽

Systematic Review ◽

Prospective Studies ◽

Stereotactic Body Radiotherapy ◽

Meta Analysis

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Association Between One-carbon Metabolism-related Vitamins and Risk of Breast Cancer: A Systematic Review and Meta-analysis of Prospective Studies

Clinical Breast Cancer ◽

10.1016/j.clbc.2020.02.012 ◽

2020 ◽

Vol 20 (4) ◽

pp. e469-e480 ◽

Cited By ~ 1

Author(s):

Jie Zeng ◽

Yi Gu ◽

Hongjuan Fu ◽

Chang Liu ◽

Yixin Zou ◽

...

Keyword(s):

Breast Cancer ◽

Systematic Review ◽

Prospective Studies ◽

Carbon Metabolism ◽

Meta Analysis ◽

One Carbon Metabolism

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Daily sodium consumption and CVD mortality in the general population: systematic review and meta-analysis of prospective studies

Public Health Nutrition ◽

10.1017/s1368980014000949 ◽

2014 ◽

Vol 18 (4) ◽

pp. 695-704 ◽

Cited By ~ 37

Author(s):

Rosana Poggio ◽

Laura Gutierrez ◽

María G Matta ◽

Natalia Elorriaga ◽

Vilma Irazola ◽

...

Keyword(s):

Systematic Review ◽

Relative Risk ◽

General Population ◽

Prospective Studies ◽

Meta Analysis ◽

Cochrane Library ◽

Random Effects Models ◽

Meta Regression ◽

Cvd Mortality

AbstractObjectiveThe purpose of the present study was to determine whether elevated dietary Na intake could be associated with CVD mortality.DesignWe performed a systematic review and meta-analysis of prospective studies representing the general population. The adjusted relative risks and their 95 % confidence intervals were pooled by the inverse variance method using random-effects models. Heterogeneity, publication bias, subgroup and meta-regression analyses were performed.SettingsMEDLINE (since 1973), Embase (since 1975), the Cochrane Library (since 1976), ISI Web of Science, Google Scholar (until September 2013) and secondary referencing were searched for inclusion in the study.SubjectEleven prospective studies with 229 785 participants and average follow-up period of 13·37 years (range 5·5–19 years).ResultsHigher Na intake was significantly associated with higher CVD mortality (relative risk=1·12; 95 % CI 1·06, 1·19). In the sensitivity analysis, the exclusion of studies with important relative weights did not significantly affect the results (relative risk=1·08; 95 % CI 1·01, 1·15). The meta-regression analysis showed that for every increase of 10 mmol/d in Na intake, CVD mortality increased significantly by 1 % (P=0·016). Age, hypertensive status and length of follow-up were also associated with increased CVD mortality.ConclusionsHigher Na intake was associated with higher CVD mortality in the general population; this result suggests a reduction in Na intake to prevent CVD mortality from any cause.

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