Corrigendum to: Medicinal plants from the Himalayan region for potential novel antimicrobial and anti-inflammatory skin treatments

: One of the principal causes of different disorders is an uncontrolled inflammatory response. Alkaloids, flavonoids, polyphenolic, proanthocyanidin, terpenoid, and steroid compounds are the main reasons for the anti-inflammatory activities of medicinal herbs and plants. The current manuscript introduces a series of potential anti-inflammatory plants, particularly those which are routines in Iranian and Chinese traditional herbal medicine, and simplifies the function and mechanisms of natural constituents for the prevention and treatment of inflammatory disorders. PubMed, Science Direct, Google Scholar, Wiley Online Library, Springer, Taylor, Francis, etc., have been used to search for collecting of scientific publications for a full evaluation of current documentation in the literature showing the importance of medicinal plants with anti-inflammatory characteristics and natural medicines. The most notable medicinal plants with anti-inflammatory activities are Baccharis dracunculifolia, Aconitum bulleyanum, Crateya adansonii, Alliums spp., Centella asiatica, Flos lonicerae, Corydalis dubia, Syringae folium, Coptis chinensis, Casearia decandra, Nigella sativa, Cannabis sativa, Tamarindus indica L., Glycyrrhiza glabra, Panax ginseng, Panax notoginseng, Pistacia vera, Smilax china, Scutellaria baicalensis, Rosemarinus officinalis, Moringa olifera, Pulsatilla radix, Pistacia atlantica, Rullia tuberose, Canarium album, Dodonaea polyandra, Forsythia suspense, Polygala tenuifolia, Radiz Isatidis, Hypericum sampsonii, Geranium koreanum, Typha capensis, Isatidis folium, Ginkgo biloba, Houttuynia cordata, snow lotus, etc. Herbal medicine mainly uses numerous parts of plants or combinations of them to prevent and remedy diseases and promote health. More investigations and clinical experiments are needed to provide more information on the importance of medicinal plants as well as their roles in the treatment and prevention of inflammatory diseases.

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Molecular pharmacology of inflammation: Medicinal plants as anti-inflammatory agents

Pharmacological Research ◽

10.1016/j.phrs.2018.11.001 ◽

2019 ◽

Vol 139 ◽

pp. 126-140 ◽

Cited By ~ 39

Author(s):

Shumaila Tasneem ◽

Bin Liu ◽

Bin Li ◽

M. Iqbal Choudhary ◽

Wei Wang

Keyword(s):

Medicinal Plants ◽

Molecular Pharmacology ◽

Anti Inflammatory

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Screening of medicinal plants used in Lesotho for anti-bacterial and anti-inflammatory activity

Journal of Ethnopharmacology ◽

10.1016/s0378-8741(99)00035-5 ◽

1999 ◽

Vol 67 (3) ◽

pp. 347-354 ◽

Cited By ~ 79

Author(s):

T.L Shale ◽

W.A. Stirk ◽

J. van Staden

Keyword(s):

Medicinal Plants ◽

Inflammatory Activity ◽

Anti Inflammatory

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Thymus algeriensis and Artemisia herba-alba Essential Oils: Chemical Analysis, Antioxidant Potential and In Vivo Anti-Inflammatory, Analgesic Activities, and Acute Toxicity

Molecules ◽

10.3390/molecules26226780 ◽

2021 ◽

Vol 26 (22) ◽

pp. 6780

Author(s):

Khadija El Ouahdani ◽

Imane Es-safi ◽

Hamza Mechchate ◽

Mohammed Al-zahrani ◽

Ashraf Ahmed Qurtam ◽

...

Keyword(s):

Antioxidant Activity ◽

Free Radical ◽

Medicinal Plants ◽

Essential Oils ◽

Iron Reduction ◽

Radical Scavenging ◽

Bioactive Molecules ◽

Potential Toxicity ◽

Thymus Algeriensis ◽

Anti Inflammatory

The study of bioactive molecules of natural origin is a focus of current research. Thymus algeriensis and Artemisia herba-alba are two medicinal plants widely used by the Moroccan population in the traditional treatment of several pathologies linked to inflammation. This study aimed to evaluate the single and combined antioxidant, anti-inflammatory and analgesic effects of the essential oils extracted from these two medicinal plants, and also their potential toxicity. Essential oils were extracted using hydro-distillation in a Clevenger-type apparatus. The antioxidant activity was evaluated by two methods: the scavenging of the free radical DPPH, and the reduction in iron. Anti-inflammatory activity was evaluated by evaluating the edema development induced by carrageenan injecting, while the analgesic power was evaluated according to the number of abdominal contortions induced by the intraperitoneal injection of acetic acid (0.7%). The acute oral toxicity was performed to assess the potential toxicity of the studied EOs, followed by an analysis of the blood biochemical parameters. The results of the two antioxidant tests indicated that our extract mixture exhibits good iron reduction capacity and very interesting DPPH free radical scavenging power, with an IC50 of around 4.38 ± 0.98 μg/mL higher than that of the benchmark antioxidant, BHT. The anti-inflammatory test demonstrated that the mixture administered orally at a dose of 150 mg/kg has a better activity, exceeding that of 1% Diclofenac, with a percentage of maximum inhibition of the edema of 89.99 ± 4.08. The number of cramps in the mice treated with the mixture at a dose of 150 mg/kg is significantly lower (29.80 ± 1.92) than those of the group treated with Tramadol (42.00 ± 2.70), respectively. The toxicity results show no signs of toxicity with an LD50 greater than 150 mg/Kg. These interesting results show that the two plants’ EOs had an important anti-inflammatory, analgesic, and antioxidant activity, and also a powerful synergistic effect, which encourages further in-depth investigations on their pharmacological proprieties.

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Influence of traditional Chinese anti-inflammatory medicinal plants on leukocyte and platelet functions

Journal of Pharmacy and Pharmacology ◽

10.1211/0022357021620 ◽

2003 ◽

Vol 55 (9) ◽

pp. 1275-1282 ◽

Cited By ~ 64

Author(s):

J. M. Prieto ◽

M. C. Recio ◽

R. M. Giner ◽

S. Máñez ◽

E. M. Giner-Larza ◽

...

Keyword(s):

Medicinal Plants ◽

Anti Inflammatory ◽

Platelet Functions

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Diversity, Distribution, Indigenous Uses and Conservation of Medicinal Plants in Nargu Wildlife Sanctuary, North Western Himalaya

Journal of Non Timber Forest Products ◽

10.54207/bsmps2000-2015-1t1240 ◽

2015 ◽

Vol 22 (4) ◽

pp. 181-201

Author(s):

Pankaj Sharma ◽

Sher Samant ◽

Lalit Tewari

Keyword(s):

Medicinal Plants ◽

Plant Species ◽

Gastrointestinal Disease ◽

Himalayan Region ◽

Ex Situ ◽

Herbal Remedies ◽

Poor People ◽

Wildlife Sanctuary ◽

Medicinal Species ◽

Natural Habitats

In the Indian Himalayan Region, the use of medicinal plants is still a tradition continued by local people or ethnic communities and Traditional Medicine Systems play an important role in daily health care of poor people. The use of plants as medicine is slowly increasing in the developed world because they have minor or no side effects. The present study was conducted in Nargu Wildlife Sanctuary of Himachal Pradesh as the total dependency of the stakeholders on nearby forests for medicinal resources. In the present study, we reported 371 plant species that are used by the people in and around Nargu WLS as medicine. Distribution of maximum species (297 spp.) occurred between 1801-2800 m zone and only 40 species were present above 3800m. Of the total medicinal species recorded, 163 spp. were native to the Himalayan region and 24 spp. native to the Himalaya and other biogeographically regions. Rests (184 spp.) were non-native. The most frequently cured disease category (108 spp.) was gastrointestinal disease. Stakeholders of the Sanctuary and surrounding villages have rich indigenous knowledge of the use of medicinal plants to maintain their primary health. Traditional herbal remedies are important and effective because many traditional uses are scientifically proven through phytochemical and pharmacological studies. However, a large number of plant species remain untested for bio-efficacy and toxicity. Such tests may reveal novel remedies that have bioprospecting potential. Moreover, the study emphasizes the need for the conservation of such precious medicinal resource of the area by managing and conserving the natural habitats, checking unscientific exploitation and by applying in-situ and various ex-situ conservation methods.

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