Medicinal Herbs with Anti-Inflammatory Activities for Natural and Organic Healing

2021 ◽  
Vol 25 ◽  
Author(s):  
Mohamad Hesam Shahrajabian
Keyword(s):  
Herbal Medicine ◽  
Medicinal Plants ◽  
Cannabis Sativa ◽  
Inflammatory Diseases ◽  
Nigella Sativa ◽  
Centella Asiatica ◽  
Medicinal Herbs ◽  
Scientific Publications ◽  
Anti Inflammatory ◽  
Clinical Experiments

: One of the principal causes of different disorders is an uncontrolled inflammatory response. Alkaloids, flavonoids, polyphenolic, proanthocyanidin, terpenoid, and steroid compounds are the main reasons for the anti-inflammatory activities of medicinal herbs and plants. The current manuscript introduces a series of potential anti-inflammatory plants, particularly those which are routines in Iranian and Chinese traditional herbal medicine, and simplifies the function and mechanisms of natural constituents for the prevention and treatment of inflammatory disorders. PubMed, Science Direct, Google Scholar, Wiley Online Library, Springer, Taylor, Francis, etc., have been used to search for collecting of scientific publications for a full evaluation of current documentation in the literature showing the importance of medicinal plants with anti-inflammatory characteristics and natural medicines. The most notable medicinal plants with anti-inflammatory activities are Baccharis dracunculifolia, Aconitum bulleyanum, Crateya adansonii, Alliums spp., Centella asiatica, Flos lonicerae, Corydalis dubia, Syringae folium, Coptis chinensis, Casearia decandra, Nigella sativa, Cannabis sativa, Tamarindus indica L., Glycyrrhiza glabra, Panax ginseng, Panax notoginseng, Pistacia vera, Smilax china, Scutellaria baicalensis, Rosemarinus officinalis, Moringa olifera, Pulsatilla radix, Pistacia atlantica, Rullia tuberose, Canarium album, Dodonaea polyandra, Forsythia suspense, Polygala tenuifolia, Radiz Isatidis, Hypericum sampsonii, Geranium koreanum, Typha capensis, Isatidis folium, Ginkgo biloba, Houttuynia cordata, snow lotus, etc. Herbal medicine mainly uses numerous parts of plants or combinations of them to prevent and remedy diseases and promote health. More investigations and clinical experiments are needed to provide more information on the importance of medicinal plants as well as their roles in the treatment and prevention of inflammatory diseases.

scholarly journals IN VITRO STUDY OF ANTI-INFLAMMATORY AND ANTIOXIDANT ACTIVITY OF SOME MEDICINAL PLANTS AND THEIR INTERRELATIONSHIP

2018 ◽  
Vol 11 (4) ◽  
pp. 195 ◽  
Author(s):  
Shubhi Rastogi ◽  
Mohammed Shariq Iqbal ◽  
Deepak Ohri
Keyword(s):  
Antioxidant Activity ◽  
Medicinal Plants ◽  
Aqueous Extract ◽  
Cannabis Sativa ◽  
Methanolic Extract ◽  
In Vitro Study ◽  
Strong Positive Correlation ◽  
Total Antioxidant ◽  
Anti Inflammatory

 Objective: The objective of the present work is to study the in vitro anti-inflammatory and antioxidant activity of medicinal plants. The extent and correlation between anti-inflammatory and antioxidant activity have been studied.Method: Methanolic and aqueous extracts of five medicinal plants, namely, Ficus racemosa, Aloe vera, Cannabis sativa, Datura stramonium, and Calotropis gigantean have been taken for in vitro anti-inflammatory and total antioxidant activity.Result: The study showed that the inhibition of protein (albumin) denaturation was maximum in aqueous extract of A. vera with 97.55±1.45%. Proteinase inhibitory action of different plant extracts showed significant action and was found to be maximum in aqueous extract of D. stramonium with 87.89±2.58%. Heat-induced hemolysis showed that maximum inhibition was with aqueous extract of F. racemosa with 90.72±3.33%. When hypotonicity-induced hemolysis activity was done it was found maximum in methanolic extract of C. gigantea with 90.58±3.04%. Anti-lipoxygenase activity was found maximum in methanolic extract of F. racemosa with 94.05±4.24%. When total antioxidant activity was done, it was found highest in F. racemosa (4.38±0.546 mM equivalent of ascorbic acid/g tissue).Conclusion: An overall strong positive correlation between anti-inflammatory and antioxidant activity was observed, indicating that antioxidant activity of the plant species studied might be responsible for their anti-inflammatory property. Further work needs to be undertaken to fully elucidate the antioxidants responsible for anti-inflammatory action and to develop better herbal drug formulations.

scholarly journals Observing the Anti-oxidant and Anti-inflammatory Effect of Nigella Sativa Combined With Silybum Marianum Extracts on the Acute Peritonitis Mouse Model

2021 ◽  
Vol 24 (3) ◽  
pp. 372-385
Author(s):  
Maryam Bahrami ◽  
◽  
Ali Ghazavi ◽  
Ali Ganji ◽  
Ghasem Mosayebi ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Therapeutic Potential ◽  
Inflammatory Diseases ◽  
Nigella Sativa ◽  
Control Group ◽  
Silybum Marianum ◽  
Acute Peritonitis ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Background and Aim: In addition to free radicals such as Nitric Oxide (NO), inflammation is one of the most important pathophysiological causes of peritonitis. Over thousands of years, Nigella Sativa (NS) and Silybum Marianum (SM) are two plants known for their anti-oxidant and anti-inflammatory properties. However, the effect of its compound is unclear. Thus, in this study, we evaluated the anti-inflammatory effect of NS and SM extracts and their combination on inflammatory diseases like thioglycollate peritoneal. Methods & Materials: Alcoholic extracts of SM and NS were obtained by the soxhlet method. Male Balb/C mice were divided into 5 groups and gavage orally for 14 days with SM, NS, the mixture of extracts of these two, DMSO 30% as the control group, and dexamethasone as the positive control group. The safety profile and acute toxicity in mice were assessed. On day 10, acute peritonitis was induced by thioglycollate 3%. Finally, the total anti-oxidant power and NO concentration were measured by FRAP and Griess method, respectively, in the serum of treated mice. Ethical Considerations: All experimental process was performed following the guidelines according to the Animal Ethics Committee of Arak University of Medical Sciences (IR.ARAKMU.REC.1397.359). Results: Acute toxicity test showed no significant changes in weight and physical appearance of the mice. However, the extract and their mixture decreased NO level significantly (P=0.000) in serum. Also, the mixture significantly increased total anti-oxidant power (P=0.015). Conclusion: Results showed that the SM and NS extract mixture demonstrated anti-inflammatory activity, inhibiting inflammatory mediators such as NO and increasing anti-oxidant power, thus supporting its therapeutic potential in slowing down inflammatory processes in inflammation disorders.

scholarly journals OVERVIEW ON PLANT CASSIA SOPHERA LINN

2020 ◽  
pp. 11-13
Author(s):  
Shivakant Shukla ◽  
Anoop Singh
Keyword(s):  
Side Effects ◽  
Herbal Medicine ◽  
Medicinal Herbs ◽  
Comprehensive Review ◽  
Unani Medicine ◽  
Synthetic Chemicals ◽  
Medicinal Value ◽  
Anti Inflammatory ◽  
Important Drug ◽  
Monsoon Forests

Medicinal herbs are moving from fringe to mainstream use, with a more significant number of people seeking remedies and health approaches free from side effects caused by synthetic chemicals Cassia sophera Linn. (Caesalpinaceae), an important drug in Unani medicine, act as a blood purifier, carminative, purgative, digestive, and diaphoretic. Many compounds have been reported from plants belonging to genus Cassia. This article aims to provide a comprehensive review of the phytochemical and pharmacological aspects of Cassia sophera. It is obtained from deciduous and mixed-monsoon forests throughout greater parts of India, ascending to 1300 m in outer Himalaya. It is widely used in the traditional medicinal system of India has been reported to possess analgesic, anticonvulsant, antioxidant, anti-inflammatory, hepatoprotective and antiasthmatic activity, etc. India officially recognizes over 3000 plants for their medicinal value. It is generally estimated that over 6000 plants in India are in use in traditional, folk, and herbal medicine.

scholarly journals Efficacy of Iranian Traditional Medicine in the Treatment of Epilepsy

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Mehri Abdollahi Fard ◽  
Asie Shojaii
Keyword(s):  
Herbal Medicine ◽  
Medicinal Plants ◽  
Nigella Sativa ◽  
Anticonvulsant Effect ◽  
Brain Disorder ◽  
Active Constituent ◽  
Piper Longum ◽  
Alpinia Officinarum ◽  
Iranian Traditional Medicine ◽  
Traditional Iranian Medicine

Epilepsy is a brain disorder which affects about 50 million people worldwide. Ineffectiveness of the drugs in some cases and the serious side effects and chronic toxicity of the antiepileptic drugs lead to use of herbal medicine as a form of complementary and alternative medicine. In this review modern evidences for the efficacy of antiepileptic medicinal plants in Traditional Iranian Medicine (TIM) will be discussed. For this purpose electronic databases including PubMed, Scopus, Sciencedirect, and Google Scholar were searched for each of the antiepileptic plants during 1970-February 2013.Anticonvulsant effect of some of the medicinal plants mentioned in TIM likeAnacyclus pyrethrum, Pimpinella anisum, Nigella sativa,andFerula gummosawas studied with different models of seizure. Also for some of these plants likeNigella sativaorPiper longumthe active constituent responsible for antiepileptic effect was isolated and studied. For some of the herbal medicine used in TIM such asPistacia lentiscusgum (Mastaki),Bryonia alba(Fashra),Ferula persica(Sakbinaj),Ecballium elaterium(Ghesa-al Hemar), andAlpinia officinarum(Kholanjan) there is no or not enough studies to confirm their effectiveness in epilepsy. It is suggested that an evaluation of the effects of these plants on different epileptic models should be performed.

DOSAGE AND ADMINISTRATION LENGTH OF CENTELLA ASIATICA (L.) URBAN DECREASE THE LEVEL OF SOD AND MDA AND IMPROVE BRAIN HISTOLOGICAL CONDITION OF RATS

2016 ◽  
Vol 78 (5) ◽  
Author(s):  
Bayyinatul Muchtaromah ◽  
Mujahidin Ahmad ◽  
Suyono Suyono ◽  
Romaidi Romaidi ◽  
Samsul Bahri ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Nervous System ◽  
Herbal Medicine ◽  
Medicinal Plants ◽  
Medicinal Plant ◽  
Centella Asiatica ◽  
Dosage Forms ◽  
Diabetic Rat ◽  
Traditional Herbal Medicine ◽  
Degenerative Disorders

Medicinal plants have been used for treating many kinds of illness due to their safety, cheap and easy to be accessed by all level of society. This study was aimed to determine the effect of the dosage forms (fresh, boiled and ethanol extracted) and the duration (24 and 42 days) of medicinal plant Centella asiatica to the levels of superoxide dismutase (SOD), malondialdehyde (MDA) and the histopathology of diabetic rat brain. The results showed that administration of various dosage forms of C. asiatica were able to increase the number of pyramid cells and neuroglia in the cerebrum significantly (P <0.01) but had no significant effect (P>0.01) at the administration length and the interaction between both treatments. This finding resulted in the new traditional herbal medicine that can be used for treating degenerative disorders on nervous system.

scholarly journals The Therapeutic Potential of Cannabis in Counteracting Oxidative Stress and Inflammation

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4551
Author(s):  
Michał Graczyk ◽  
Agata Anna Lewandowska ◽  
Tomasz Dzierżanowski
Keyword(s):  
Clinical Evidence ◽  
Cannabis Sativa ◽  
Therapeutic Potential ◽  
State Of The Art ◽  
Inflammatory Diseases ◽  
Chronic Inflammatory Diseases ◽  
Inflammatory Conditions ◽  
Cannabinoid Compounds ◽  
Antioxidative Effects ◽  
Anti Inflammatory

Significant growth of interest in cannabis (Cannabis sativa L.), especially its natural anti-inflammatory and antioxidative properties, has been observed recently. This narrative review aimed to present the state of the art of research concerning the anti-inflammatory activity of all classes of cannabinoids published in the last five years. Multimodal properties of cannabinoids include their involvement in immunological processes, anti-inflammatory, and antioxidative effects. Cannabinoids and non-cannabinoid compounds of cannabis proved their anti-inflammatory effects in numerous animal models. The research in humans is missing, and the results are unconvincing. Although preclinical evidence suggests cannabinoids are of value in treating chronic inflammatory diseases, the clinical evidence is scarce, and further well-designed clinical trials are essential to determine the prospects for using cannabinoids in inflammatory conditions.

scholarly journals Therapeutic Promises of Medicinal Plants in Bangladesh and Their Bioactive Compounds against Ulcers and Inflammatory Diseases

Plants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1348
Author(s):  
Sheikh Rashel Ahmed ◽  
Muhammad Fazle Rabbee ◽  
Anindita Roy ◽  
Rocky Chowdhury ◽  
Anik Banik ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Bioactive Compounds ◽  
Inflammatory Diseases ◽  
Gastric Ulcers ◽  
Active Components ◽  
Synthetic Drugs ◽  
Bowel Diseases ◽  
Anti Inflammatory ◽  
Irritable Bowel ◽  
Biological Entities

When functioning properly, the stomach is the center of both physical and mental satisfaction. Gastrointestinal disorders, or malfunctioning of the stomach, due to infections caused by various biological entities and physiochemical abnormalities, are now widespread, with most of the diseases being inflammatory, which, depending on the position and degree of inflammation, have different names such as peptic or gastric ulcers, irritable bowel diseases, ulcerative colitis, and so on. While many synthetic drugs, such as non-steroidal anti-inflammatory drugs, are now extensively used to treat these diseases, their harmful and long-term side effects cannot be ignored. To treat these diseases safely and successfully, different potent medicinal plants and their active components are considered game-changers. In consideration of this, the present review aimed to reveal a general and comprehensive updated overview of the anti-ulcer and anti-inflammatory activities of medicinal plants. To emphasize the efficacy of the medicinal plants, various bioactive compounds from the plant extract, their experimental animal models, and clinical trials are depicted.

scholarly journals Medicinal Potential of Jamun (Syzygium cumini Linn): A Review

2019 ◽  
Vol 9 (5) ◽  
pp. 175-180 ◽  
Author(s):  
Nadeem Ahmad ◽  
Mohammad Nawab ◽  
M Husain Kazmi
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plants ◽  
Experimental Studies ◽  
Stem Bark ◽  
Syzygium Cumini ◽  
Classical Literature ◽  
Scientific Publications ◽  
Anti Inflammatory ◽  
Main Components ◽  
Loss Of Appetite

Unani System of Medicine (USM) is being practised as traditional, alternative and complementary medicine in India and other countries. In this system of medicine, medicinal plants are extensively used in the treatment of various kind of diseases since time immemorial. Herbo-mineral origin drugs are the main components of Unani Pharmacopoeia. Jamun (Syzygium cumini Linn) is one of the medicinal plants used for therapeutic purposes in Dhayābīṭus Ḥārr (diabetes mellitus),  Ishāl-e- Damwī (haemorrhagic diarrhoea), Is’haal-i-Safrāwī (bilious diarrhoea), Ḍu‘f al-Ishtihā’(loss of appetite), Zaḥīr (dysentery) and Qulā (oral ulcer). In recent past its fruits, seeds, leaves, stem bark and its secondary metabolites have shown medicinal properties in various experimental and clinical studies. In this review we have tried to explore its ethno-botanical uses and pharmacological actions described in classical literature and scientific publications based on experimental studies. It is found that this plant plays an important role in prevention and management of non-communicable diseases such as Dhayābīṭus Ḥārr (diabetes mellitus), Sarṭān (cancer), Niqris (gout), ischaemic heart disease etc. Several preclinical studies have revealed that it has Muḥallil-i- Awrām (anti-inflammatory), Muḥāfiẓ-i- Qalb (cardio protective), Dafi‘-i-Ḥummā (anti-pyretic) and Muqawwī-i-Jigar (hepatotonic) properties. It also possesses anti-diabetic potential activity and considered as a potent anti-diabetic plant. Keywords: Unani, Jamun, Syzygium, Antidiabetic, Anti-inflammatory, Hepatoprotective

scholarly journals Medicinal Plants in COVID-19: Potential and Limitations

2021 ◽  
Vol 12 ◽  
Author(s):  
Xin Yi Lim ◽  
Bee Ping Teh ◽  
Terence Yew Chin Tan
Keyword(s):  
Medicinal Plants ◽  
Medicinal Plant ◽  
Low Income ◽  
Nigella Sativa ◽  
Immunomodulatory Effects ◽  
Eurycoma Longifolia ◽  
Low Income Groups ◽  
Anti Inflammatory ◽  
Novel Coronavirus ◽  
Evidence Summaries

Currently, the search to identify treatments and vaccines for novel coronavirus disease (COVID-19) are ongoing. Desperation within the community, especially among the middle-and low-income groups acutely affected by the economic impact of forced lockdowns, has driven increased interest in exploring alternative choices of medicinal plant-based therapeutics. This is evident with the rise in unsubstantiated efficacy claims of these interventions circulating on social media. Based on enquiries received, our team of researchers was given the chance to produce evidence summaries evaluating the potential of complementary interventions in COVID-19 management. Here, we present and discuss the findings of four selected medicinal plants (Nigella sativa, Vernonia amygdalina, Azadirachta indica, Eurycoma longifolia), with reported antiviral, anti-inflammatory, and immunomodulatory effects that might be interesting for further investigation. Our findings showed that only A. indica reported positive antiviral evidence specific to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) based on preliminary in silico data while all four medicinal plants demonstrated differential anti-inflammatory or immunomodulatory effects. The definitive roles of these medicinal plants in cytokine storms and post-infection complications remains to be further investigated. Quality control and standardisation of medicinal plant-based products also needs to be emphasized. However, given the unprecedented challenges faced, ethnopharmacological research should be given a fair amount of consideration for contribution in this pandemic.

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