scholarly journals Squamous cell carcinoma mimics small cell carcinoma of the lung: a case report

2020 ◽  
Vol 2020 (12) ◽  
Author(s):  
Michael Kmeid ◽  
Breanne Gillie ◽  
Armand Asarian ◽  
Philip Xiao
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Squamous Cell ◽  
Lung Tumors ◽  
Small Cell ◽  
World Health ◽  
Lung Cancers ◽  
Lung Carcinomas ◽  
The Usa ◽  
Health Organization

Abstract Squamous cell carcinomas (SCC) accounts for roughly 20% of lung cancers in the USA. The 2015 World Health Organization classification of lung tumors further categorizes SCC as three subtypes: keratinizing, non-keratinizing and basaloid variant. The non-keratinizing subtype is a poorly differentiated tumor that can present histologically in different ways, and one of which is a rare variant that strongly resembles small cell carcinoma. As a result, histological diagnosis alone is not sufficient to properly diagnose lung carcinomas. Immunohistochemistry has been increasingly used over the past few years to differentiate between lung tumors. The combination of morphological and immunohistochemical staining should be the mainstay for diagnosis of all lung carcinomas as more targeted therapies become more available.

Synchronous Triple Carcinoma of the Lung in One Patient

1987 ◽  
Vol 73 (5) ◽  
pp. 525-529 ◽  
Author(s):  
Paolo Badiali ◽  
Marco Alloisio ◽  
Luciano Lombardi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Squamous Cell ◽  
Lower Lobe ◽  
Small Cell ◽  
Simultaneous Occurrence ◽  
Lung Carcinomas ◽  
The Right ◽  
Common Cell

A case is reported of the simultaneous occurrence of a squamous cell carcinoma and a small cell carcinoma, both centrally located, in the right upper lobe and a peripheral adenocarcinoma in the right lower lobe. The simultaneous occurrence of three primary lung carcinomas is discussed in the light of a probable common cell origin.

A resected case of multiple primary lung cancers composed of adenocarcinoma, squamous cell carcinoma and small cell carcinoma.

Haigan ◽  
1990 ◽  
Vol 30 (7) ◽  
pp. 1043-1047
Author(s):  
Masazumi Watanabe ◽  
Koichi Kobayashi ◽  
Tsuneo Ishihara ◽  
Akira Kawai ◽  
Takeo Kawashiro ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Squamous Cell ◽  
Small Cell ◽  
Lung Cancers ◽  
Multiple Primary ◽  
Resected Case

Human papillomavirus‐associated small cell carcinoma with synchronous squamous cell carcinoma in the nasopharynx: Report of a rare case

Cytopathology ◽  
2020 ◽  
Author(s):  
Weihong Ma ◽  
Guy Betts ◽  
Michael Dykes ◽  
Dominic St Leger ◽  
Alexandra Sargent ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Squamous Cell ◽  
Rare Case ◽  
Small Cell

scholarly journals Small Cell Carcinoma of the Uterine Cervix Misdiagnosed as Squamous Cell Carcinoma

2012 ◽  
Vol 2 (1) ◽  
Author(s):  
Aymen Lagha ◽  
Nadia Bouzid ◽  
Samia Kanoun Belajouza ◽  
Soumaya Labidi ◽  
Asma Saiidi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Squamous Cell ◽  
Uterine Cervix ◽  
Small Cell

Napsin A, a New Marker for Lung Adenocarcinoma, Is Complementary and More Sensitive and Specific Than Thyroid Transcription Factor 1 in the Differential Diagnosis of Primary Pulmonary Carcinoma: Evaluation of 1674 Cases by Tissue Microarray

2012 ◽  
Vol 136 (2) ◽  
pp. 163-171 ◽  
Author(s):  
Bradley M. Turner ◽  
Philip T. Cagle ◽  
Irma M. Sainz ◽  
Junya Fukuoka ◽  
Steven S. Shen ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Squamous Cell ◽  
Lung Squamous Cell Carcinoma ◽  
Negative Control ◽  
Small Cell ◽  
Tumor Type ◽  
Napsin A ◽  
N 93

Context.—Differentiation of non–small cell carcinoma into histologic types is important because of new, successful therapies that target lung adenocarcinoma (ACA). TTF-1 is a favored marker for lung ACA but has limited sensitivity and specificity. Napsin A (Nap-A) is a functional aspartic proteinase that may be an alternative marker for primary lung ACA. Objectives.—To compare Nap-A versus TTF-1 in the typing of primary lung carcinoma and the differentiation of primary lung ACA from carcinomas of other sites. Design.—Immunohistochemistry for Nap-A and TTF-1 was performed on tissue microarrays of 1674 cases of carcinoma: 303 primary lung ACAs (18.1%), 200 primary squamous cell lung carcinomas (11.9%), 52 primary small cell carcinomas of the lung (3.1%), and carcinomas of the kidney (n  =  320; 19.1%), thyroid (n  =  96; 5.7%), biliary (n  =  89; 5.3%), bladder (n  =  47; 2.8%), breast (n  =  93; 5.6%), colon (n  =  95; 5.7%), liver (n  =  96; 5.7%), ovaries (n  =  45; 2.7%), pancreas (n  =  48; 2.9%), prostate (n  =  49; 2.9%), stomach (n  =  93; 5.6%), and uterus (n  =  48; 2.9%). Cases were evaluated against a negative control as negative, weak positive, and strong positive. Results.—Nap-A was more sensitive than TTF-1 for primary lung ACA (87% versus 64%; P < .001). Nap-A was more specific than TTF-1 for primary lung ACA versus all tumors, excluding kidney, independent of tumor type (P < .001). Conclusions.—Nap-A is superior to TTF-1 in distinguishing primary lung ACA from other carcinomas (except kidney), particularly primary lung small cell carcinoma, and primary thyroid carcinoma. A combination of Nap-A and TTF-1 is useful in the distinction of primary lung ACA (Nap-A+, TTF-1+) from primary lung squamous cell carcinoma (Nap-A−, TTF-1−) and primary lung small cell carcinoma (Nap-A−, TTF-1+).

scholarly journals Distinction of pulmonary small cell carcinoma from poorly differentiated squamous cell carcinoma: an immunohistochemical approach

2004 ◽  
Vol 18 (1) ◽  
pp. 111-118 ◽  
Author(s):  
Hong Zhang ◽  
Jing Liu ◽  
Philip T Cagle ◽  
Timothy C Allen ◽  
Alvaro C Laga ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Squamous Cell ◽  
Small Cell ◽  
Poorly Differentiated

Primary Combined Squamous and Small Cell Carcinoma of the Larynx: A Case Report and Review of the Literature

2004 ◽  
Vol 128 (11) ◽  
pp. 1279-1282
Author(s):  
Vilkesh R. Jaiswal ◽  
Mai P. Hoang
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Squamous Cell ◽  
Small Cell ◽  
Squamous Cell Carcinomas ◽  
Review Of The Literature ◽  
The Past ◽  
Laryngeal Carcinomas ◽  
Carcinoma Of The Larynx ◽  
Combined Small Cell Carcinoma

Abstract Primary laryngeal carcinomas comprise approximately 2% to 5% of all malignancies worldwide. Of these laryngeal carcinomas, approximately 99% are primary squamous cell carcinomas. During the past 30 years, about 160 cases of primary small cell carcinoma of the larynx have been reported. Combined primary squamous and small cell carcinoma of the larynx, the so-called composite tumor of the larynx, is even more rare, with only 13 published cases to date. Although the major risk factors for developing these composite tumors of the larynx are thought to be similar to other more common neoplasms of the larynx, such as squamous cell carcinoma, the treatment and prognosis are different. We report an additional case of combined small cell carcinoma of the larynx and discuss the histogenesis of this unusual neoplasm.

Nuclear DNA Content in Squamous Cell Carcinoma, Small Cell Carcinoma, and Bronchiolo-Alveolar Carcinoma of the Lung

1987 ◽  
Vol 10 (4) ◽  
pp. 330-334 ◽  
Author(s):  
K. Yoneyama ◽  
K. Erhardt ◽  
G. Auer ◽  
L.-G. Wiman ◽  
B. Stenkvist ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Squamous Cell ◽  
Dna Content ◽  
Nuclear Dna ◽  
Nuclear Dna Content ◽  
Small Cell
Sign in / Sign up

Export Citation Format

Share Document