Managing behavioural and psychological symptoms in Alzheimer’s disease

2011 ◽  
Author(s):  
Philippe Robert ◽  
Elsa Leone ◽  
Hélène Amieva
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Psychological Symptoms ◽  
Individual Risk ◽  
Behavioural And Psychological Symptoms ◽  
Psychotropic Agents ◽  
Pharmacological Medication ◽  
The Individual ◽  
Behavioural Management ◽  
Limited Period

• The behavioural and psychological symptoms of dementia (BPSD) form an important part of the clinical picture of Alzheimer’s disease (AD)• Anti-dementia agents may facilitate behavioural management of AD and may decrease the use of psychotropic agents• Management should preferentially be non-pharmacological Medication is to be prescribed only after assessment of the individual risk/benefit ratio. The prescription should be for a limited period and frequently re-assessed...

Evidence-based management of behavioural and psychological symptoms of dementia

2017 ◽  
pp. 1015-1020
Author(s):  
Anne Corbett ◽  
Clive Ballard ◽  
Byron Creese
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Psychological Symptoms ◽  
Evidence Based ◽  
Pharmacological Treatments ◽  
Complex Needs ◽  
Clinical Guidance ◽  
Prevention And Treatment ◽  
Behavioural And Psychological Symptoms ◽  
The Individual

Behavioural and psychological symptoms of dementia (BPSD) are common in people with Alzheimer’s disease (AD). They include agitation, aggression, psychosis and depression, and can cause great distress for the individual and their caregivers. Dementia represents a considerable challenge for treatment and care due to the complex needs of people with the condition. Management of BPSD is particularly challenging due to the lack of effective pharmacological treatments, and current clinical guidance is complex. This chapter outlines the causes and impacts of BPSD in people with AD. In particular, it explores the evidence supporting the use of both pharmacological and non-pharmacological treatments and the role they play in the prevention and treatment of BPSD.

Managing behavioural and psychological symptoms in Alzheimer’s disease

2017 ◽  
Author(s):  
Philippe Robert ◽  
Elsa Leone ◽  
Hélène Amieva ◽  
David Renaud
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Limbic System ◽  
Psychological Symptoms ◽  
Line Treatment ◽  
Second Line ◽  
Cerebral Dysfunction ◽  
Behavioural And Psychological Symptoms ◽  
Pharmacologic Treatments ◽  
The Individual

This chapter focuses on the behavioural and psychological symptoms of Alzheimer's disease and the different approaches clinicians can take in their treatment of the condition. The behavioural and psychological symptoms are defined as primary manifestations of cerebral dysfunction, and appear specifically as a result of damage to a system or circuit such as the limbic system or the cortico-subcortical circuits. During the progression of Alzheimer’s disease, the presence of at least one BPSD is common and can vary, depending especially on the severity of the dementia-related syndrome at the time of diagnosis. Management of BPSD should preferentially be based on non-pharmacologic approaches first. Pharmacologic treatments should constitute second line treatment and are to be prescribed only after assessment of the individual risk:benefit ratio.

scholarly journals Caregiver distress associated with behavioral and psychological symptoms in mild Alzheimer's disease

2010 ◽  
Vol 4 (3) ◽  
pp. 238-244 ◽  
Author(s):  
Ari Pedro Balieiro Jr. ◽  
Emmanuelle Silva Tavares Sobreira ◽  
Marina Ceres Silva Pena ◽  
José Humberto Silva-Filho ◽  
Francisco de Assis Carvalho do Vale
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Psychological Symptoms ◽  
Time Behavior ◽  
Caregiver Distress ◽  
Night Time ◽  
The Mean ◽  
The Individual ◽  
The Relationship ◽  
Behavioral And Psychological Symptoms

Abstract The aim of this study was to analyze the relationship between Caregiver Distress and Behavioral and Psychological Symptoms in Dementias (BPSD) in mild Alzheimer's disease. Methods: Fifty patients and caregivers were interviewed using the Neuropsychiatric Inventory (NPI). Results: 96.0% of the patients had at least one BPSD. The mean NPI total score was 19.6 (SD=18.05; range=0-78) whereas the mean Caregiver Distress Index (CDI) total score was 11.5 (SD=10.41; range=0-40). For the individual symptoms, the weighted mean CDI was 2.8 (SD=1.58). All symptom CDI means were higher than 2.0 except for euphoria/elation (m=1.8; SD=1.49). There were correlations between CDI and derived measures (Frequency, Severity, FxS, and Amplitude) for all symptoms, except Disinhibition and Night-time behavior. Correlations ranged between 0.443 and 0.894, with significance at p<0.05. Conclusions: All the derived measures, including amplitude, were useful in at least some cases. The data suggests that CDI cannot be inferred from symptom presence or profile. Symptoms should be systematically investigated.

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