Introduction: Life after the ICU

2014 ◽  
Author(s):  
Margaret Herridge
Keyword(s):  
Critical Illness ◽  
Distress Syndrome ◽  
The Family ◽  
Related Quality ◽  
Health Related ◽  
Risk Modifier

Chapter 1 introduces a section about recovery from critical illness, and discusses the magnitude and burden of critical illness (including acute respiratory distress syndrome (ARDS) and post-ARDS residual pulmonary disease, and compromised health-related quality of life (HRQoL)), its mortality, detailed morbidity (ICU-based risk factors for long-term disability), and costs. It also examines the central role of the family caregiver as outcome and risk modifier.

Thrombopoietin Receptor Agonists in Children with Immune Thrombocytopenia: A New Therapeutic Era

2020 ◽  
Vol 20 ◽  
Author(s):  
Giuseppe Lassandro ◽  
Valentina Palladino ◽  
Giovanni Carlo Del Vecchioa ◽  
Viviana Valeria Palmieri ◽  
Paola Carmela Corallo ◽  
...  
Keyword(s):  
Immune Thrombocytopenia ◽  
Treatment Options ◽  
Thrombopoietin Receptor Agonists ◽  
Receptor Agonists ◽  
Thrombopoietin Receptor ◽  
Related Quality ◽  
Health Related

Background and Objective: Immune thrombocytopenia (ITP) is a common bleeding disorder in childhood. The management of ITP in children is controversial, requiring personalized assessment of patients and therapeutic choices. Thrombopoietin receptor agonists (TPO-RAs), eltrombopag and romiplostim, have been shown to be safety and effective for the treatment of pediatric ITP. The aim of our research is defining the role of thrombopoietin receptor agonists in the management of pediatric ITP. Method: This review focuses on the use of TPO-RAs in pediatric ITP, in randomized trials and in clinical routine, highlighting their key role in management of the disease. Results: Eltrombopag and romiplostim appear effective treatment options for children with ITP. Several clinical studies have assessed that the use of TPO-RAs increases platelet count, decreases bleeding symptoms and improves health-related quality of life. Moreover, TPO-RAs are well tolerated with minor side effects. Conclusion: Although TPO-RAs long term efficacy and safety still require further investigations, their use is gradually expanding in clinical practice of children with ITP.

scholarly journals Long-term survival and health-related quality of life in patients with severe acute respiratory distress syndrome and veno-venous extracorporeal membrane oxygenation support

Critical Care ◽  
2021 ◽  
Vol 25 (1) ◽  
Author(s):  
Jonathan Rilinger ◽  
Klara Krötzsch ◽  
Xavier Bemtgen ◽  
Markus Jäckel ◽  
Viviane Zotzmann ◽  
...  
Keyword(s):  
Distress Syndrome ◽  
Term Survival ◽  
Long Term Survival ◽  
Sf 36 ◽  
Related Quality ◽  
Health Related ◽  
Vv Ecmo

Abstract Background There is limited information about the long-term outcome of patients suffering from acute respiratory distress syndrome (ARDS) supported with veno-venous extracorporeal membrane oxygenation (VV ECMO). Most studies focused on short- to mid-term follow-up. We aimed to investigate long-term survival and health-related quality of life (HRQL) in these patients. Methods We report retrospective data from a single-centre registry of patients with severe ARDS treated with VV ECMO at the Interdisciplinary Medical Intensive Care Unit at the Medical Centre, University of Freiburg, Germany, between 10/2010 and 06/2019. Follow-up data of all patients that survived the index hospitalisation were collected by telephone interviews from 02/2020 till 09/2020. Long-term survival, HRQL (Short-Form Health Survey-36 (SF-36), St. Georges Respiratory Questionnaire (SGRQ), Hospital Anxiety and Depression Scale (HADS)) and the return to work rate were documented. Results In total, 289 patients were treated with VV ECMO during the study period (median age 55 years, 67% males, hospital survival 45%). After a median duration of 3.9 years, follow-up assessment was complete in 94 of 129 hospital survivors (73%). Fifty-three patients completed the HRQL assessment. Hospital survivors showed a high 6- and 12-month survival rate (89% and 85%, respectively). Estimated survival rate of those discharged alive from ICU was 68.5% (95%-CI 56.9–80.1%) after 9.7 years. These patients reported high levels of HRQL (median SF-36 total score 73) and only few pulmonary (median SGRQ total score 19) and mental limitations (median HAD-D score 2 and HAD-A score 3). In total, 80% of the patients were able to resume employment. Conclusion This analysis of VV ECMO patients showed favourable long-term survival and high levels of HRQL suggesting promising prospects for VV ECMO survivors. Graphical Abstract

Long-Term Association Between Frailty and Health-Related Quality of Life Among Survivors of Critical Illness

2015 ◽  
Vol 43 (5) ◽  
pp. 973-982 ◽  
Author(s):  
Sean M. Bagshaw ◽  
H. Thomas Stelfox ◽  
Jeffrey A. Johnson ◽  
Robert C. McDermid ◽  
Darryl B. Rolfson ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Critical Illness ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Patterns of Recovery after Critical Illness

2014 ◽  
Author(s):  
Nishant K Sekaran ◽  
Theodore J Iwashyna
Keyword(s):  
Critical Illness ◽  
World Health ◽  
International Classification Of Functioning ◽  
Participation Restriction ◽  
Adequate Description ◽  
Related Quality ◽  
Health Related

There are at least as many ways to recover from critical illness as there are to become critically ill. This chapter argues that, to understand recovery, we need to understand both its trajectory and the different domains in which recovery occurs. An adequate description of recovery should include pre-illness characteristics, depth of problems during the acute illness, the rate and duration of recovery, the extent of peak recovery, and long-term differences in post-illness trajectory. It should also take seriously the distinct domains mapped out in the World Health Organization’s International Classification of Functioning (ICF): tissue impairment, activity limitations, participation restriction, and health-related quality of life. These domains each represent distinct and important facets, and separately assessing each leads to deeper understanding and opportunities for intervention.

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