Practice points for radiation oncology

2016 ◽  
pp. 173-185
Author(s):  
Annekatrin Seidlitz ◽  
Stephanie E. Combs ◽  
Jürgen Debus ◽  
Michael Baumann

Radiotherapy is an indispensable treatment modality in modern oncology with curative potential in applying ionizing radiation in a wide spectrum of malignancies. Radiotherapy is often combined in multidisciplinary concepts with surgery or cytostatic drugs, and increasingly also with molecular-targeted therapies. The aim of radiotherapy is to achieve uncomplicated local or locoregional tumour control, that is to permanently inactivate all cancer cells in the irradiated volume without inducing severe normal tissue reactions. This aim can be reached for a substantial proportion of patients with modern high-precision radiation treatment planning and application technologies. Clinical and radiobiological principles guide the radiation oncologist in time-dose volume prescription of radiotherapy and in selection of the optimal radiation treatment plan for the individual patient. The scope of this chapter is to summarize important basic biological, physical, and clinical principles and practice points of radiotherapy of relevance for the non-radiation oncologist.

Author(s):  
Annekatrin Seidlitz ◽  
Stephanie E. Combs ◽  
Jürgen Debus ◽  
Michael Baumann

Radiotherapy is an indispensable treatment modality in modern oncology with curative potential in applying ionizing radiation in a wide spectrum of malignancies. Radiotherapy is often combined in multidisciplinary concepts with surgery or cytostatic drugs, and increasingly also with molecular-targeted therapies. The aim of radiotherapy is to achieve uncomplicated local or locoregional tumour control, that is to permanently inactivate all cancer cells in the irradiated volume without inducing severe normal tissue reactions. This aim can be reached for a substantial proportion of patients with modern high-precision radiation treatment planning and application technologies. Clinical and radiobiological principles guide the radiation oncologist in time-dose volume prescription of radiotherapy and in selection of the optimal radiation treatment plan for the individual patient. The scope of this chapter is to summarize important basic biological, physical, and clinical principles and practice points of radiotherapy of relevance for the non-radiation oncologist.


2012 ◽  
Vol 30 (34_suppl) ◽  
pp. 211-211
Author(s):  
Thomas S. McGowan ◽  
Sophie Foxcroft ◽  
Michael Donald Brundage ◽  
Michael Sharpe ◽  
Eric Gutierrez ◽  
...  

211 Background: The use of peer-review activities in oncology is not well described as a quality improvement process. We sought to describe current patterns of practice of radiation oncology peer-review across a large Provincial Cancer program and to identifiy barriers to its use. Methods: Ontario cancer centres were surveyed. Survey item responses were typically scored using a 10-point Likert scale. The survey was administered electronically with follow-up reminders as required. The use of free-text for comments elaborating on responses was encouraged. Results: Fourteen (100%) centres responded. All rated the importance of peer-review as at least 8/10 (10=extremely important). Detection of medical error and improvement of planning processes were the highest-rated benefits of peer-review (each median 9/10). Four centres (29%) conducted peer-review in more than 80% of cases treated with curative intent; six (43%) peer-reviewed at least 50% of curative cases. Five centres (36%) reported “always” or “almost always” conducting peer-review prior to the initiation of treatment. Variation was seen in which aspects of a case were typically reviewed (e.g., GTV “almost always” reviewed in 67%; contouring of organs at risk in 50%). Five centres (46% of those with regular peer-review) reported that 5% to 9% of peer-reviewed cases were flagged as requiring a change, whereas 3 centres (27%) reported that < 2% of peer-reviewed cases required a change to be made. Five centres (36%) recorded the outcomes of peer-review on the medical record. Thirteen centres (93%) planned to expand peer-review activities; the two factors rated as most limiting to expanding peer-review were a critical mass of radiation oncologists (median score 6/10), and prioritization of peer review by the program overall (median 5/10). Conclusions: Peer review in radiation oncology practices it is now widely used as a quality assurance activity in Ontario, identifies changes to improve quality in the individual case, and improves departmental process. The development of guidelines and standards for peer-review activities, coupled with effective knowledge translation activities are recommended.


Author(s):  
Fudong Nian ◽  
Jie Sun ◽  
Dashan Jiang ◽  
Jingjing Zhang ◽  
Teng Li ◽  
...  

Dose-volume histogram (DVH) is an important tool to evaluate the radiation treatment plan quality, which could be predicted based on the distance-volume spatial relationship between planning target volumes (PTV) and organs-at-risks (OARs). However, the prediction accuracy is still limited due to the complicated calculation process and the omission of detailed spatial geometric features. In this paper, we propose a spatial geometric-encoding network (SGEN) to incorporate 3D spatial information with an efficient 2D convolutional neural networks (CNN) for accurate prediction of DVH for esophageal radiation treatments. 3D computed tomography (CT) scans, 3D PTV scans and 3D distance images are used as the multi-view input of the proposed model. The dilation convolution based Multi-scale concurrent Spatial and Channel Squeeze & Excitation (msc-SE) structure in the proposed model not only can maintain comprehensive spatial information with less computation cost, but also can extract the features of organs at different scales effectively. Five-fold cross-validation on 200 intensity-modulated radiation therapy (IMRT) esophageal radiation treatment plans were used in this paper. The mean absolute error (MAE) of DVH focusing on the left lung can achieve 2.73 ± 2.36, while the MAE was 7.73 ± 3.81 using traditional machine learning prediction model. In addition, extensive ablation studies have been conducted and the quantitative results demonstrate the effectiveness of different components in the proposed method.


2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e14043-e14043
Author(s):  
Don Stacy ◽  
Christopher Rucker ◽  
Kimberly Cottongame ◽  
Lester Combs ◽  
Chad Jones ◽  
...  

e14043 Background: To prospectively determine the need for SRS/SRT at a hospital-based cancer center lacking SRS/SRT capability. Methods: An experienced SRS/SRT radiation oncologist prospectively evaluated new and established patients for radiation treatment at a hospital-based cancer center from July 30, 2018 through September 20, 2019. All radiation treatment options (per the NCCN Practice Guidelines in Oncology) were explained in detail to each patient. The radiation oncologist’s specific treatment recommendation to each patient was based on the radiation oncologist’s expertise. Cases for which the radiation oncologist recommended SRS/SRT were recorded. Results: From August 06, 2018 through September 25, 2019 an experienced SRS/SRT radiation oncologist evaluated 177 new or established patients for radiation treatment and recommended SRS/SRT for 23 patients (6 lung, 2 adrenal, 9 brain, 3 spine, 1 pituitary, 1 bone, and 1 prostate). Conclusions: To provide comprehensive radiation oncology patient services, SRS/SRT capability is required at a hospital-based cancer center evaluated by an experienced SRS/SRT radiation oncologist in this report, as SRS/SRT was recommended for twenty-three of one hundred seventy-seven (13%) patients evaluated for radiation treatment in a fourteen-month period.


2021 ◽  
Vol 6 (S1) ◽  
pp. 21-26
Author(s):  
Sweta Soni ◽  
Akanksha Solanki ◽  
Puneet Pareek ◽  
Rakesh Kumar Vyas ◽  
Sumanta Manna ◽  
...  

Purpose: To build safe environment for cancer fighters and radiation personnel during COVID-19 pandemic by focusing on infection control, workflow and radiotherapy dose schedules modification strategies in radiation oncology departments. Material and Methods: A meeting was called post lock down in radiation oncology department to prepare infection control policies and workflow strategies in time of COVID-19 Pandemic.Results: Strategies and policies were formed during COVID-19 crises taking following points into consideration 1) Infection control policies 2) CT simulation policies 3) Day care admission and chemotherapy administration policies 4) Radiation treatment plan modification and delivery strategies 5) Brachytherapy delivery strategies.Conclusion: Management of cancer patients is an issue running parallel to the present condition of COVID-19 pandemic. Further randomized trial on hypofractionated radiotherapy schedules should be encouraged. Positivity, awareness and systematic approach are most important step in balancing the current scenario.


2010 ◽  
Vol 49 (S 01) ◽  
pp. S11-S15
Author(s):  
C. Schütze ◽  
M. Krause ◽  
A. Yaromina ◽  
D. Zips ◽  
M. Baumann

SummaryRadiobiological and cell biological knowledge is increasingly used to further improve local tumour control or to reduce normal tissue damage after radiotherapy. Important research areas are evolving which need to be addressed jointly by nuclear medicine and radiation oncology. For this differences of the biological distribution of diagnostic and therapeutic nuclides compared with the more homogenous dose-distribution of external beam radiotherapy have to be taken into consideration. Examples for interdisciplinary biology-based cancer research in radiation oncology and nuclear medicine include bioimaging of radiobiological parameters characterizing radioresistance, bioimage-guided adaptive radiotherapy, and the combination of radiotherapy with molecular targeted drugs.


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