Upper Motor Neuron Disorders Hereditary Spastic Paraplegia and Primary Lateral Sclerosis
Keyword(s):
Upper motor neuron (UMN) syndromes are a group of rare, degenerative neurological disorders that are classified as either hereditary spastic paraplegia (HSP) or primary lateral sclerosis (PLS). Our understanding of their underlying pathophysiology is unfortunately very limited and has been a significant barrier to the development of disease-modifying treatments. Recent advances in genetics and in vitro and in vivo disease modeling have provided new insights into disease mechanisms and hold the promise to lead to the future development of mechanism-based therapies.
2005 ◽
Vol 6
(1)
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pp. 8-16
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2005 ◽
Vol 6
(2)
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pp. 67-76
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Keyword(s):
2000 ◽
Vol 13
(2)
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pp. 60-64
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2007 ◽
Vol 64
(10)
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pp. 1545
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