scholarly journals Effects of nitrous acid treatment on the survival and mutagenesis of Escherichia coli cells lacking base excision repair(hypoxanthine-DNA glycosylase-ALK A protein) and/or nucleotide excision repair

Mutagenesis ◽  
1997 ◽  
Vol 12 (1) ◽  
pp. 23-28 ◽  
Author(s):  
Olga Sidorkina ◽  
Murat Saparbaev ◽  
Jacques Laval
Keyword(s):  
Escherichia Coli ◽  
Nucleotide Excision Repair ◽  
Base Excision Repair ◽  
Nitrous Acid ◽  
Acid Treatment ◽  
Excision Repair ◽  
Dna Glycosylase ◽  
Escherichia Coli Cells ◽  
Nucleotide Excision ◽  
Base Excision

DNA base excision repair and nucleotide excision repair proteins in malignant salivary gland tumors

2021 ◽  
Vol 121 ◽  
pp. 104987
Author(s):  
Fernanda Aragão Felix ◽  
Leorik Pereira da Silva ◽  
Maria Luiza Diniz de Sousa Lopes ◽  
Ana Paula Veras Sobral ◽  
Roseana de Almeida Freitas ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Nucleotide Excision Repair ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Salivary Gland Tumors ◽  
Dna Base Excision Repair ◽  
Dna Base ◽  
Nucleotide Excision ◽  
Base Excision ◽  
Malignant Salivary Gland Tumors

scholarly journals Multiprobe RNase Protection Assay Analysis of mRNA Levels for the Escherichia coli Oxidative DNA Glycosylase Genes under Conditions of Oxidative Stress

2000 ◽  
Vol 182 (19) ◽  
pp. 5416-5424 ◽  
Author(s):  
Christine M. Gifford ◽  
Jeffrey O. Blaisdell ◽  
Susan S. Wallace
Keyword(s):  
Escherichia Coli ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Dna Glycosylase ◽  
Mrna Levels ◽  
Aerobic Growth ◽  
Rnase Protection ◽  
Transcript Levels ◽  
Endonuclease Iii ◽  
Base Excision

ABSTRACT Escherichia coli formamidopyrimidine DNA glycosylase (Fpg), MutY DNA glycosylase, endonuclease VIII, and endonuclease III are oxidative base excision repair DNA glycosylases that remove oxidized bases from DNA, or an incorrect base paired with an oxidized base in the case of MutY. Since genes encoding other base excision repair proteins have been shown to be part of adaptive responses inE. coli, we wanted to determine whether the oxidative DNA glycosylase genes are induced in response to conditions that cause the type of damage their encoded proteins remove. The genesfpg, mutY, nei, and nthencode Fpg, MutY, endonuclease VIII, and endonuclease III, respectively. Multiprobe RNase protection assays were used to examine the transcript levels of these genes under conditions that induce the SoxRS, OxyR, and SOS regulons after a shift from anaerobic to aerobic growth and at different stages along the growth curve. Transcript levels for all four genes decreased as cells progressed from log-phase growth to stationary phase and increased after cells were shifted from anaerobic to aerobic growth. None of the genes were induced by hydrogen peroxide, paraquat, X rays, or conditions that induce the SOS response.

Polymorphisms in base-excision repair and nucleotide-excision repair genes in relation to lung cancer risk

2007 ◽  
Vol 631 (2) ◽  
pp. 101-110 ◽  
Author(s):  
Kim De Ruyck ◽  
Marcin Szaumkessel ◽  
Isabelle De Rudder ◽  
Annelore Dehoorne ◽  
Anne Vral ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Nucleotide Excision Repair ◽  
Base Excision Repair ◽  
Lung Cancer Risk ◽  
Excision Repair ◽  
Nucleotide Excision ◽  
Base Excision ◽  
Repair Genes

scholarly journals The involvement of nucleotide excision repair proteins in the removal of oxidative DNA damage

2020 ◽  
Vol 48 (20) ◽  
pp. 11227-11243 ◽  
Author(s):  
Namrata Kumar ◽  
Sripriya Raja ◽  
Bennett Van Houten
Keyword(s):  
Nucleotide Excision Repair ◽  
Base Excision Repair ◽  
Oxidative Dna Damage ◽  
Excision Repair ◽  
Base Damage ◽  
The Past ◽  
Nucleotide Excision ◽  
Oxidative Processes ◽  
Repair Pathways ◽  
Base Excision

Abstract The six major mammalian DNA repair pathways were discovered as independent processes, each dedicated to remove specific types of lesions, but the past two decades have brought into focus the significant interplay between these pathways. In particular, several studies have demonstrated that certain proteins of the nucleotide excision repair (NER) and base excision repair (BER) pathways work in a cooperative manner in the removal of oxidative lesions. This review focuses on recent data showing how the NER proteins, XPA, XPC, XPG, CSA, CSB and UV-DDB, work to stimulate known glycosylases involved in the removal of certain forms of base damage resulting from oxidative processes, and also discusses how some oxidative lesions are probably directly repaired through NER. Finally, since many glycosylases are inhibited from working on damage in the context of chromatin, we detail how we believe UV-DDB may be the first responder in altering the structure of damage containing-nucleosomes, allowing access to BER enzymes.

scholarly journals Contribution of Base Excision Repair, Nucleotide Excision Repair, and DNA Recombination to Alkylation Resistance of the Fission Yeast Schizosaccharomyces pombe

2000 ◽  
Vol 182 (8) ◽  
pp. 2104-2112 ◽  
Author(s):  
Asli Memisoglu ◽  
Leona Samson
Keyword(s):  
Dna Repair ◽  
Schizosaccharomyces Pombe ◽  
Nucleotide Excision Repair ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Dna Recombination ◽  
Nucleotide Excision ◽  
Repair Pathways ◽  
Base Excision

ABSTRACT DNA damage is unavoidable, and organisms across the evolutionary spectrum possess DNA repair pathways that are critical for cell viability and genomic stability. To understand the role of base excision repair (BER) in protecting eukaryotic cells against alkylating agents, we generated Schizosaccharomyces pombe strains mutant for the mag1 3-methyladenine DNA glycosylase gene. We report that S. pombe mag1 mutants have only a slightly increased sensitivity to methylation damage, suggesting that Mag1-initiated BER plays a surprisingly minor role in alkylation resistance in this organism. We go on to show that other DNA repair pathways play a larger role than BER in alkylation resistance. Mutations in genes involved in nucleotide excision repair (rad13) and recombinational repair (rhp51) are much more alkylation sensitive thanmag1 mutants. In addition, S. pombe mutant for the flap endonuclease rad2 gene, whose precise function in DNA repair is unclear, were also more alkylation sensitive thanmag1 mutants. Further, mag1 andrad13 interact synergistically for alkylation resistance, and mag1 and rhp51 display a surprisingly complex genetic interaction. A model for the role of BER in the generation of alkylation-induced DNA strand breaks in S. pombe is discussed.

Base excision repair and nucleotide excision repair contribute to the removal of N-methylpurines from active genes

DNA Repair ◽  
2002 ◽  
Vol 1 (8) ◽  
pp. 683-696 ◽  
Author(s):  
Brian Plosky ◽  
Leona Samson ◽  
Bevin P Engelward ◽  
Barry Gold ◽  
Brenda Schlaen ◽  
...  
Keyword(s):  
Nucleotide Excision Repair ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Nucleotide Excision ◽  
Base Excision ◽  
Active Genes
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