scholarly journals Post-transcriptional regulation of the chicken thymidine kinase gene

1984 ◽  
Vol 12 (3) ◽  
pp. 1427-1446 ◽  
Author(s):  
Mark Groudine ◽  
Colin Casimir
Keyword(s):  
Transcriptional Regulation ◽  
Thymidine Kinase ◽  
Thymidine Kinase Gene ◽  
Kinase Gene ◽  
Post Transcriptional Regulation

scholarly journals G1/S-regulated E2F-containing protein complexes bind to the mouse thymidine kinase gene promoter.

1994 ◽  
Vol 269 (2) ◽  
pp. 1306-1313
Author(s):  
Q.P. Dou ◽  
S. Zhao ◽  
A.H. Levin ◽  
J. Wang ◽  
K. Helin ◽  
...  
Keyword(s):  
Thymidine Kinase ◽  
Protein Complexes ◽  
Gene Promoter ◽  
Thymidine Kinase Gene ◽  
Kinase Gene

scholarly journals Hybrid plasmids containing an active thymidine kinase gene of Herpes simplex virus 1

1979 ◽  
Vol 7 (4) ◽  
pp. 859-878 ◽  
Author(s):  
N.M. Wilkie ◽  
J.B. Clements ◽  
W. Boll ◽  
N. Mantei ◽  
D. Lonsdale ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Thymidine Kinase ◽  
Thymidine Kinase Gene ◽  
Herpes Simplex Virus 1 ◽  
Kinase Gene ◽  
Simplex Virus

scholarly journals Genetic analysis of the human thymidine kinase gene promoter.

1986 ◽  
Vol 6 (8) ◽  
pp. 2903-2909 ◽  
Author(s):  
J A Kreidberg ◽  
T J Kelly
Keyword(s):  
Thymidine Kinase ◽  
Base Pair ◽  
Promoter Region ◽  
Genomic Sequence ◽  
Gene Promoter ◽  
Thymidine Kinase Gene ◽  
Rich Region ◽  
Kinase Gene ◽  
Inverted Orientation ◽  
Pair Sequence

The promoter of the human thymidine kinase gene was defined by DNA sequence and genetic analyses. Mutant plasmids with deletions extending into the promoter region from both the 5' and 3' directions were constructed. The mutants were tested in a gene transfer system for the ability to transform TK- cells to the TK+ phenotype. This analysis delimited the functional promoter to within an 83-base-pair region upstream of the mRNA cap site. This region contains sequences common to other eucaryotic promoters including G X C-rich hexanucleotides, a CAAT box, and an A X T-rich region. The CAAT box is in an inverted orientation and is part of a 9-base-pair sequence repeated twice in the promoter region. Comparison of the genomic sequence with the cDNA sequence defined the first exon of the thymidine kinase gene.

Are hepatomas a good target for suicide gene therapy? An experimental study in rats using retroviral-mediated transfer of thymidine kinase gene

Surgery ◽  
1998 ◽  
Vol 123 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Héléna Nagy ◽  
Yves Panis ◽  
Monique Fabre ◽  
Hubert Perrin ◽  
David Klatzmann ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Experimental Study ◽  
Thymidine Kinase ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Thymidine Kinase Gene ◽  
Kinase Gene ◽  
Good Target
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