Effects of defibrotide treatment in patients with IgA nephropathy and reduced renal function

2017 ◽  
Vol 89 (8) ◽  
pp. 77-79
Author(s):  
N V Chebotareva ◽  
I N Bobkova ◽  
S V Gulyaev

The paper describes a rare clinical case of rheumatoid arthritis (RA) that developed in a patient 9 years after diagnosing IgA nephropathy. Kidney disease was characterized by a stable course with moderate urinary syndrome, hypertension, and reduced renal function. Immunosuppressive therapy using glucocorticosteroids and then mycophenolic acid led to remission of nephritis and recovery of renal function. However, the absence of nephritis activity and discontinuation of immunosuppressants was responsible for articular syndrome. The diagnosis of RA is based on its characteristic radiological patterns and immunological characteristics after ruling out a number of systemic diseases and infections. The common pathogenetic components of IgA nephropathy and RA, including the role of rheumatoid factor IgA, are discussed.


1996 ◽  
Vol 11 (2) ◽  
pp. 392-393 ◽  
Author(s):  
G. M. Frasca ◽  
M. Manello ◽  
E. Sestigiani ◽  
C. Canova ◽  
A. Vangelista ◽  
...  

2018 ◽  
Vol 46 (7) ◽  
pp. 2549-2557 ◽  
Author(s):  
Yamei Wang ◽  
Yuhong Tao

Immunoglobulin A nephropathy (IgAN) is the most frequent pathological diagnosis of tuberculosis (TB)-associated glomerulonephritis. Diagnosing TB-associated IgAN (TB-IgAN) is difficult because of its non-specific and insidious symptoms. An inaccurate diagnosis of TB-IgAN could result in the spread of TB and reduced renal function. Haematuria and proteinuria in conjunction with TB should be assessed because of the potential for diagnosis of IgAN. Renal biopsy is important in securing an accurate diagnosis prior to initiating treatment. Detection of Mycobacterium tuberculosis DNA and assessment of early secreted antigenic target of 6 kDa in renal biopsy tissues may have great potential diagnostic value in patients with TB-IgAN. Anti-TB therapy can effectively alleviate TB and TB-IgAN.


2011 ◽  
Vol 12 (1) ◽  
Author(s):  
Kisara Onda ◽  
Isao Ohsawa ◽  
Hiroyuki Ohi ◽  
Mariko Tamano ◽  
Satoshi Mano ◽  
...  

Author(s):  
K. Fukushi ◽  
H. Yamabe ◽  
K. Ozawa ◽  
H. Ohsawa ◽  
N. Chiba ◽  
...  

2012 ◽  
Vol 20 (01) ◽  
pp. 023-029
Author(s):  
MOHAMMAD ASIF ◽  
ATIF ULLAH ◽  
MUHAMMAD AKRAM

Chronic kidney disease (CKD) is characterized by progressive destruction of renal mass with irreversible sclerosis andloss of nephrons.Various metabolic, hematological and endocrine abnormalities are known to occur in CKD. Subclinical hypothyroidismis an important endocrine abnormality associated with a greater cardiovascular risk, atherosclerosis and an important factor forprogression of renal disease in such patients. Objective: To calculate the frequency of subclinical hypothyroidism in predialysis CKDpatients. Design: Cross sectional survey. Setting: Pathology Department Post Graduate Medical Institute, Lahore. Period: 06 months(June 2011 to Dec 2011). Results: 210 patients were included in the study. Serum creatinine. TSH and FT4 were measured and therelevant data was entered in predesigned proforma. 19.5 % of CKD population had subclinical hypothyroidism with slightly increasedpreponderance in females as compared to males and also increased frequency as the stage of CKD increased. Subclinicalhypothyroidism is more common in CKD population. Conclusions: Increased frequency of subclinical hypothyroidism was found inpatients with reduced renal function not on dialysis. 19.5% of CKD population on conservative management had labortary evidence ofthyroid dysfunction.


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