scholarly journals P1843NEPHROLOGICAL THEMATOLOGY IN PUBLICATIONS DIACHRONICALLY APPEARING IN THE PUBMED BIBLIOGRAPHICAL DATABASE

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Ioannis Stefanidis ◽  
Athanasios Diamandopoulos
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Peritoneal Dialysis ◽  
Renal Transplantation ◽  
Renal Biopsy ◽  
Historical Analysis ◽  
Medical Specialty ◽  
Pubmed Database ◽  
Number Of Publications ◽  
First Time

Abstract Background and Aims Nephrology is a medical specialty, which in the last 50 years experienced very important scientific developments, which formally revolutionized clinical practice, namely renal biopsy, renal replacement therapy and transplantation. In addition understanding pathogenesis and clinic of renal disease also improves steadily, resulting in renewal of definitions, classifications and therapeutics in nephrology. In this context publications with nephrological content are also expanding. The aim of this bibliography-study was to analyze the publications, related to nephrology specific keywords, as they appear in the PubMed database. Method Certain nephrology related keywords were applied: “nephrology”, “acute renal failure”, “renal biopsy”, “hemodialysis”, “peritoneal dialysis” and “renal transplantation” were applied as terms in PubMed. Instead of renal kidney was used as an alternative term. Results Nephrology as a term appears 141573 times in the database and beginning from 1946 its appearance is expanding in the last three decades. The term “acute renal failure” is found for the time in 1932 in one publication and in a total number 92278 of publications. Renal biopsy appears from 1943 in a total number of 15506 publications. Hemodialysis appears in 182730 citations for the first time in 1915 in human application. Peritoneal dialysis appears in 32266 citations for the first time in 1901 and 1946 in human application. One publication on renal transplantation appears in 1946 and the total number of publications related to renal transplantation is 106075. Conclusion According to the above findings there is a clear expansion of nephrological publications in the last decades. In addition, hemodialysis remains still the most frequent term used in nephrology related publications. Historical analysis the PubMed database is very useful as a tool to understand the research and publication trends in nephrology, as we approach to the new era of precision medicine.

Successful Treatment of aHUS Recurrence and Arrest of Plasma Exchange Resistant TMA Post-Renal Transplantation with the Terminal Complement Inhibitor Eculizumab.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 2421-2421 ◽  
Author(s):  
Daniel J Legault ◽  
Mark R Boelkins
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Acute Renal Failure ◽  
Renal Transplantation ◽  
Serum Creatinine ◽  
Renal Biopsy ◽  
Thrombotic Microangiopathy ◽  
Complement Inhibitor ◽  
Post Transplant ◽  
Terminal Complement

Abstract Abstract 2421 Poster Board II-398 Atypical hemolytic uremic syndrome (aHUS) is a rare thrombotic microangiopathy characterized by microangiopathic hemolytic anemia, consumptive thrombocytopenia, and acute renal failure (ARF). The prognosis for aHUS is poor as 25% of patients die during acute phases of the disease and 50% progress to end stage renal disease (ESRD). A high percentage of patients with aHUS experience recurrence and graft failure following renal transplantation. This report summarizes the successful use of a terminal complement inhibitor as a treatment for aHUS following renal transplant with demonstration of both clinical and pathological resolution of aHUS in a patient who was resistant to plasma therapy. A 34-year-old female with ESRD due to aHUS underwent living related renal transplantation. Approximately one month after renal transplantation, she presented with acute renal failure (ARF), with creatinine (Cr) increasing from 1.2 to 2.2 mg/dl. The renal biopsy showed thrombotic microangiopathy (TMA). ADAMTS-13 activity was normal. Tacrolimus was discontinued and corticosteroids were initiated. She responded to 14 sessions of every-other-day plasma exchange (PLEX), with stabilization of her creatinine at 1.5mg/dl. At month 5, she again presented with ARF with a renal biopsy showing TMA. PLEX was initiated once again (3 times per week) but her serum creatinine did not improve significantly during PLEX from month 5 to month 9 and ranged from 1.9 to 2.3 mg/dL with urine protein:creatinine ratio of 1.7 to 3.0. Elevations of Cr (2.34 to 3.65mg/dLl), modest elevations in LDH (209 to 380 IU/L) and ∼20% decrease in platelets (227 to 185 × 109/L) were observed when PLEX was interrupted. Diagnostic renal biopsy during this period of PLEX dependency displayed ongoing TMA. With ongoing persistent TMA despite maximal PLEX, at month 9, treatment with eculizumab, a humanized monoclonal antibody that blocks the cleavage of the terminal complement molecule C5 and generation of pro-inflammatory C5a and C5b-9, was initiated. The patient was dosed with eculizumab 900mg weekly for 4 weeks followed by 1200mg at week 5 and 1200mg every 2 weeks thereafter. After 4 weeks of induction therapy with eculizumab and no PLEX sessions, her serum creatinine stabilized at 4.0 to 4.3 mg/dL. At month 10 post transplant, and 7 weeks after the switch from PLEX to eculizumab, renal biopsy now showed no TMA and moderate residual interstitial fibrosis. Fifteen (15) months post transplant and 6 months of eculizumab treatment, the patient continues on eculizumab maintenance therapy with no requirement for PLEX. She is experiencing her best stable renal function to date, with Cr=2.7 mg/dL, a urine protein:creatinine ratio of 2.29 as well as normal platelet counts and slightly elevated LDH (∼350 IU/L) with normal haptoglobin. These results demonstrate that PLEX following recurrent aHUS post transplant did not stabilize renal function and biopsy-proven TMA persisted despite intensive PLEX therapy post transplant. In contrast, switch of PLEX to chronic terminal complement inhibitor treatment with eculizumab resolved the TMA process, stabilized and improved the transplanted kidney function, and eliminated the need for PLEX for this patient with recurrent aHUS post transplant. Clinical trials to further investigate and confirm the efficacy of eculizumab in the treatment of aHUS are ongoing. Disclosures: Legault: Alexion Pharmaceuticals: Research Funding. Off Label Use: Eculizumab, a terminal complement inhibitor, used to treat aHUS.

Overview of blood purification in uremia

1980 ◽  
Vol 3 (4) ◽  
pp. 203-208
Author(s):  
B.T. Burton
Keyword(s):  
Renal Failure ◽  
Peritoneal Dialysis ◽  
Renal Transplantation ◽  
Rejection Rate ◽  
Blood Purification ◽  
Maintenance Hemodialysis ◽  
Dialysis Patients ◽  
Transplant Patients ◽  
Maintenance Dialysis ◽  
Transplanted Kidneys

Today, management of irreversible renal failure is based primarily on maintenance hemodialysis and renal transplantation with a growing minority of patients treated by peritoneal dialysis. With regard to renal transplantation — the early promise of renal transplantation in the mid 1960's has given way to the realities of the late 1970's. There have been no major changes in the rejection rate of transplanted kidneys in recent years though today's mortality of transplant patients is considerably reduced over what it used to be. Moreover, universally the lack of availability of a sufficient number of organs for transplantation poses a formidable problem. It is all too apparent that current methods of blood purification in uremia are far from optimal. Even though the mortality in maintenance dialysis is relatively low, hemodialysis is characterized by a variety of complications and most maintenance dialysis patients are not optimally rehabilitated.

Serial renal biopsy findings in a case of POEMS syndrome with recurrent acute renal failure

2011 ◽  
Vol 16 (1) ◽  
pp. 173-179 ◽  
Author(s):  
Atsuko Y. Higashi ◽  
Fumiaki Nogaki ◽  
Isoroku Kato ◽  
Takahiko Ono ◽  
Atsushi Fukatsu
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Renal Biopsy ◽  
Poems Syndrome

scholarly journals Peritoneal Dialysis for Acute Renal Failure in Infants: A Comparison of Three Types of Peritoneal Access

Renal Failure ◽  
1997 ◽  
Vol 19 (1) ◽  
pp. 165-170 ◽  
Author(s):  
H. S. Kohli ◽  
A. Barkataky ◽  
R. S. Vasanth Kumar ◽  
K. Sud ◽  
V Jha ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Peritoneal Dialysis

Continuous Hemodiafiltration in Children

PEDIATRICS ◽  
1990 ◽  
Vol 85 (5) ◽  
pp. 819-823
Author(s):  
Nancy A. Bishof ◽  
Thomas R. Welch ◽  
C. Frederic Strife ◽  
Frederick C. Ryckman
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Peritoneal Dialysis ◽  
Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Effective Means ◽  
Tumor Lysis Syndrome ◽  
Intermittent Hemodialysis ◽  
Tumor Lysis ◽  
Continuous Arteriovenous Hemofiltration

Continuous arteriovenous hemofiltration is a form of renal replacement therapy whereby small molecular weight solutes and water are removed from the blood via convection, alleviating fluid overload and, to a degree, azotemia. It has been used in many adults and several children. However, in patients with multisystem organ dysfunction and acute renal failure, continuous arteriovenous hemofiltration alone may not be sufficient for control of azotemia; intermittent hemodialysis or peritoneal dialysis may be undesirable in such unstable patients. Recently, the technique of continuous arteriovenous hemodiafiltration has been used in many severely ill adults. We have used continuous arteriovenous hemodiafiltration in four patients at Children's Hospital Medical Center. Patient 1 suffered perinatal asphyxia and oliguria while on extracorporeal membrane oxygenation. Patients 2 and 4 both had Burkitt lymphoma and tumor lysis syndrome. Patient 3 had septic shock several months after a bone marrow transplant. All had acute renal failure and contraindications to hemodialysis or peritoneal dialysis. A blood pump was used in three of the four patients, while spontaneous arterial flow was adequate in one. Continuous arteriovenous hemodiafiltration was performed for varying lengths of time, from 11 hours to 7 days. No patient had worsening of cardiovascular status or required increased pressor support during continuous arteriovenous hemodiafiltration. The two survivors (patients 2 and 4) eventually recovered normal renal function. Continuous arteriovenous hemodiafiltration is a safe and effective means of renal replacement therapy in the critically ill child. It may be ideal for control of the metabolic and electrolyte abnormalities of the tumor lysis syndrome.

Peritoneal dialysis for acute renal failure

1990 ◽  
Vol 18 (1) ◽  
pp. 29-31 ◽  
Author(s):  
NASRULLAH MANJI ◽  
SCOTT SHIKORA ◽  
MOLLY McMAHON ◽  
GEORGE L. BLACKBURN ◽  
BRUCE R. BISTRIAN
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Peritoneal Dialysis

Renal Biopsy in Acute Renal Failure: Its Indications and Usefulness

1984 ◽  
pp. 201-204
Author(s):  
Olivier Kourilsky ◽  
Liliane Morel-Maroger ◽  
Gabriel Richet
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Renal Biopsy

scholarly journals Surgical complications of peritoneal dialysis in children with acute kidney failure

2020 ◽  
Vol 11 (3) ◽  
pp. 57-63
Author(s):  
Dmitrii A. Dobroserdov ◽  
Mikhail V. Shchebenkov ◽  
Alexey L. Shavkin
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Peritoneal Dialysis ◽  
North West ◽  
The North ◽  
Specialized Center ◽  
Uremic Syndrome ◽  
Specialized Department ◽  
Dialysis Complications

The dialysis department of the Childrens City Multidisciplinary Clinical Specialized Center for High Medical Technologies has been operating since 1977 and is the only specialized department in the North-West Region of the Russian Federation that provides assistance to children with both acute and chronic renal failure. Peritoneal dialysis is the treatment of choice for children with acute renal failure, the most common cause of which is hemolytic-uremic syndrome. Despite widely used measures to improve the results of peritoneal dialysis, complications are extremely common. The article analyzes the complications of peritoneal dialysis in children with acute renal failure who were treated in a hospital from 2008 to 2018. The emphasis in the study is on the analysis of complications of peritoneal dialysis, in the treatment of which the surgeon actively participated or should have taken part in. If the problem of acute renal failure is multidisciplinary in the sense that it requires the participation of nephrologists, resuscitators, infectious disease specialists, then if necessary, renal replacement therapy requires the surgeon to become not only a specialist providing access, but also a full-fledged participant in the treatment process. As follows from the foregoing, the surgeons actions depend not only on the quality of dialysis, but also the timeliness and adequacy of treatment of complications, which ultimately improves or worsens the quality of medical care in general.

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