scholarly journals MP606A PREDICTIVE MODEL FOR SUCCESSFUL CONVERSION OF CONTINUOUS RENAL REPLACEMENT THERAPY TO INTERMITTENT HEMODIALYSIS FOR ACUTE KIDNEY INJURY IN CRITICAL ILL PATIENTS

2016 ◽  
Vol 31 (suppl_1) ◽  
pp. i542-i543
Author(s):  
Ji Hyeon Park ◽  
Hye Ryoun Jang ◽  
Wooseong Huh ◽  
Dae Joong Kim ◽  
Yoon-Goo Kim ◽  
...  
2019 ◽  
Author(s):  
Diana Silva Russo ◽  
Claudia Severgnini Eugênio ◽  
Illan George Balestrin ◽  
Clarissa Garcia Rodrigues ◽  
Regis Goulart Rosa ◽  
...  

Abstract Backround: The use of renal replacement therapy (RRT) in acute kidney injury (AKI) patients in the intensive care unit (ICU) is associated with high hemodynamic instability leading to a probable increase in hospital mortality. The aim of this study was to compare hemodynamic parameters among continuous, intermittent and hybrid renal replacement therapy in critical ill patients. Methods: We conducted in accordance with the PRISMA guidelines which was registered at the PROSPERO Database (CRD42018086504). Randomized clinical trials involving patients with AKI in the ICU treated with continuous, intermittent or hybrid RRT were included. We investigated the PubMed, Embase and Cochrane databases. Two reviewers independently performed study selection, evaluation of methodological quality and data extraction. Results: Out of 3442 citations retrieved, 12 randomized clinical trials (RCTs) were included, representing 1419 patients. Most of the studies (n=8) did not report or find differences in hemodynamic parameters across different RTT modalities. However, continuous venovenous hemofiltration (CVVH) was associated with a reduction in heart rate (after 1 and 4 hours) in comparison with intermittent haemodialysis (IHD) patients. CVVH was also associated with an increase in systolic blood pressure (after 0.5 and 2h) when compared with patients treated with IHD. In addition, dobutamine doses were higher in patients submitted to continuous venovenous hemodiafiltration (CVVHDF) compared to patients submitted to IHD. Lower baseline mean arterial pressure (MAP), greater MAP variation on dialysis, higher number of pressors at baseline, and increase in pressor dose during dialysis were associated with shorter survival time; and greater MAP variation on dialysis was negatively correlated with renal recovery. Conclusions: Changes in hemodynamic pattern appear be similar in different dialytic methods used in critical ill patients; however continuous venovenous hemofiltration seems be safer than other renal replacement modalities.


2020 ◽  
Author(s):  
Ankit Patel ◽  
Kenneth B Christopher

Renal replacement therapy (RRT) can be used to support patient’s kidney function in cases of acute kidney injury (AKI). However, timing, modality, and dosing of RRT continue to remain in question. Recent studies have begun to provide data to help guide clinicians on when to initiate RRT, what form of RRT to use ranging from continuous venovenous hemofiltration (VVH) to intermittent hemodialysis, and the impact of high versus low-intensity dosing. Additionally, the risks associated with temporary vascular access with regard to thrombosis and infection, the impact of high efficiency and flux versus low efficiency and flux membranes, and options for anticoagulation in RRT for AKI are also discussed. This review contains 75 references.  Key words: acute kidney injury, chronic kidney disease, continuous venovenous hemofiltration, continuous venovenous hemodialysis, renal replacement therapy, venovenous hemofiltration, 


2015 ◽  
Vol 56 (3) ◽  
pp. 658 ◽  
Author(s):  
Youn Kyung Kee ◽  
Eun Jin Kim ◽  
Kyoung Sook Park ◽  
Seung Gyu Han ◽  
In Mee Han ◽  
...  

Author(s):  
Eric Ehieli ◽  
Yuriy Bronshteyn

Patients with severe acute kidney injury who require renal replacement therapy have high mortality rates. Controversy exists over whether a mortality benefit occurs with use of a more intensive renal replacement therapy regimen. In this multicenter, prospective study, 1124 patients requiring renal replacement therapy for severe acute kidney injury were randomized to a more and a less intensive renal replacement therapy regimen and were followed for 60 days. There was no statistical difference in mortality at 60 days (53.6% intensive, 51.5% less intensive, P = 0.47) and no difference in kidney recovery or non-renal organ failure. Hypotension and electrolyte abnormalities were more common in the intensive renal replacement regimen. A less intensive renal replacement regimen (intermittent hemodialysis 3 times a week or continuous venovenous hemodiafiltration at 20ml/kg/hour) was found noninferior to a more intensive renal replacement strategy (dialysis 6 times per week or continuous venovenous hemodiafiltration at 35 ml/kg/hour).


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