Familial Predisposition and Differences in Radiographic Patterns in Spontaneous Nonaneurysmal Subarachnoid Hemorrhage

Neurosurgery ◽  
2021 ◽  
Vol 89 (Supplement_2) ◽  
pp. S94-S94
Author(s):  
Pui Man Rosalind Lai ◽  
Isaac Ng ◽  
William B Gormley ◽  
Nirav J Patel ◽  
Kai U Frerichs ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Familial Predisposition ◽  
Nonaneurysmal Subarachnoid Hemorrhage

Familial nontraumatic, nonaneurysmal subarachnoid hemorrhage: a report on three first-degree siblings

2011 ◽  
Vol 115 (3) ◽  
pp. 621-623 ◽  
Author(s):  
Christos Lazaridis ◽  
Jeffrey Bodle ◽  
Imran Chaudry ◽  
Angela Hays ◽  
Julio Chalela
Keyword(s):  
Risk Factor ◽  
Subarachnoid Hemorrhage ◽  
Family History ◽  
Environmental Factors ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Case Series ◽  
Familial Predisposition ◽  
Factors Associated ◽  
Genetic And Environmental Factors ◽  
Nonaneurysmal Subarachnoid Hemorrhage

Family history is a recognized risk factor in aneurysmal subarachnoid hemorrhage (SAH). The genetic and environmental contributions are actively researched. The authors of this report present a case series of 3 first-degree siblings affected by nontraumatic, angiographically negative SAH. Data in this study suggest that familial predisposition may also apply to spontaneous, nonaneurysmal SAH and that family history should be actively investigated in all such patients. The identification of families with multiple affected members could lead to an improved understanding of the genetic and environmental factors associated with this condition.

Familial Predisposition and Differences in Radiographic Patterns in Spontaneous Nonaneurysmal Subarachnoid Hemorrhage

Neurosurgery ◽  
2020 ◽  
Author(s):  
Pui Man Rosalind Lai ◽  
Isaac Ng ◽  
William B Gormley ◽  
Nirav J Patel ◽  
Kai U Frerichs ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Family History ◽  
Clinical Outcome ◽  
Intracranial Aneurysms ◽  
High Rate ◽  
Study Patient ◽  
Familial Predisposition ◽  
History Of ◽  
Nonaneurysmal Subarachnoid Hemorrhage ◽  
Patient Presentation

Abstract BACKGROUND Subarachnoid hemorrhage (SAH) from an intracranial aneurysmal rupture is the most common nontraumatic etiology for SAH, but up to 15% of patients with SAH have no identifiable source. OBJECTIVE To assess familial predisposition to spontaneous nonaneurysmal SAH (naSAH) and to evaluate whether family history affects the severity of presentation and prognosis of this condition. METHODS We conducted a retrospective analysis of all spontaneous SAH with negative digital subtraction angiography from 2004 to 2018. Patients were divided into 2 groups: patients with first- or second-degree relatives with intracranial aneurysms and patients with no family history. Univariate and multivariate regression analyses were used to study patient presentation, radiographic patterns of hemorrhage, and clinical outcome. RESULTS A total of 100 patients met the inclusion criteria. There were no individuals with family history of naSAH. A total of 15 patients (15%) had at least one family member with an intracranial aneurysm, of which 12 (12%) presented as SAH. Patients without family history had a higher percentage of perimesencephalic presentation, whereas those with family history had a higher percentage of nonperimesencephalic SAH presentation (47% vs 13%, odds ratio [OR] 0.17 [95% CI 0.04, 0.81]). CONCLUSION We found a high rate of family history of intracranial aneurysms in patients who presented with naSAH. Although there was no difference in clinical outcome in patients with and without family history, there appears to be a higher percentage of nonperimesencephalic radiographic patterns of SAH in those with family history, suggesting possible different etiologies of these hemorrhages.

Nonaneurysmal Subarachnoid Hemorrhage

2012 ◽  
pp. 1548-1551
Author(s):  
Neesh Pannu ◽  
Xiaoyan Wen ◽  
John A. Kellum ◽  
John Fildes ◽  
N. Al-Subaie ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Nonaneurysmal Subarachnoid Hemorrhage

Hydrocephalous as a Complication of Perimesencephalic Nonaneurysmal Subarachnoid Hemorrhage

2020 ◽  
Vol 29 (12) ◽  
pp. 105381
Author(s):  
Guilherme Zini Reis ◽  
Fernanda Subtil de Moraes Machado ◽  
Wladimir Kummer de Paula ◽  
Flávio Diniz Ribas ◽  
Felipe Ibiapina dos Reis
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Nonaneurysmal Subarachnoid Hemorrhage

Significance of a small bulge on the basilar artery in patients with perimesencephalic nonaneurysmal subarachnoid hemorrhage

2003 ◽  
Vol 98 (2) ◽  
pp. 426-429 ◽  
Author(s):  
Yuji Matsumaru ◽  
Kiyoyuki Yanaka ◽  
Ai Muroi ◽  
Hiroaki Sato ◽  
Takao Kamezaki ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Basilar Artery ◽  
Three Dimensional ◽  
Distinct Type ◽  
Rotational Angiography ◽  
Bleeding Pattern ◽  
Content Type ◽  
Nonaneurysmal Subarachnoid Hemorrhage ◽  
Excellent Clinical Outcome ◽  
Fine Print

✓ Perimesencephalic nonaneurysmal subarachnoid hemorrhage (SAH) is a distinct type of hemorrhage with a characteristic bleeding pattern and an excellent clinical outcome. The cause of this benign form of SAH remains unknown. The authors report on two cases of perimesencephalic nonaneurysmal SAH in which a small bulge on the basilar artery (BA) was demonstrated on three-dimensional rotational angiography studies. Based on data from these cases, one may infer that the lesion on the BA is responsible for the SAH. The possible pathogenesis is discussed.

scholarly journals Clinical course of nontraumatic, nonaneurysmal subarachnoid hemorrhage: a single-institution experience

2009 ◽  
Vol 26 (5) ◽  
pp. E21 ◽  
Author(s):  
Jobyna Whiting ◽  
John Reavey-Cantwell ◽  
Gregory Velat ◽  
Gregory Fautheree ◽  
Christopher Firment ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Clinical Course ◽  
False Negative ◽  
False Negative Rate ◽  
Case Series ◽  
Large Series ◽  
Morbidity And Mortality ◽  
Csf Diversion ◽  
Clinically Significant ◽  
Nonaneurysmal Subarachnoid Hemorrhage

Object Angiogram-negative subarachnoid hemorrhage (SAH) accounts for 15% of nontraumatic SAH and has been reported with low morbidity and mortality rates. We report on a large series of patients with angiogram-negative SAH who experienced an atypical nonbenign clinical course. Methods Between December 2001 and November 2006, 95 patients with spontaneous nonaneurysmal SAH and negative initial angiographic evaluation were treated at the University of Florida. The authors retrospectively reviewed the patients' medical records and radiological images to determine associated morbidity and mortality. Results Aneurysms were found in 6 of the 95 patients on follow-up imaging after an initial negative angiogram (6.3% false negative rate); these patients were excluded leaving 89 patients as the study group. Hydrocephalus necessitating temporary CSF diversion developed in 22 of these patients (25%); 12 (13%) ultimately required permanent CSF diversion. Clinically significant vasospasm developed in 4 patients (4%), and 2 (2%) had cerebral infarctions. Three patients (3%) died. Conclusions The authors' experience with a large series of angiogram-negative SAH patients who had an atypical nonbenign clinical course associated with hydrocephalus, vasospasm, stroke, and mortality differs significantly from previously published case series of angiogram-negative SAH.

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