Familial nontraumatic, nonaneurysmal subarachnoid hemorrhage: a report on three first-degree siblings

2011 ◽  
Vol 115 (3) ◽  
pp. 621-623 ◽  
Author(s):  
Christos Lazaridis ◽  
Jeffrey Bodle ◽  
Imran Chaudry ◽  
Angela Hays ◽  
Julio Chalela
Keyword(s):  
Risk Factor ◽  
Subarachnoid Hemorrhage ◽  
Family History ◽  
Environmental Factors ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Case Series ◽  
Familial Predisposition ◽  
Factors Associated ◽  
Genetic And Environmental Factors ◽  
Nonaneurysmal Subarachnoid Hemorrhage

Family history is a recognized risk factor in aneurysmal subarachnoid hemorrhage (SAH). The genetic and environmental contributions are actively researched. The authors of this report present a case series of 3 first-degree siblings affected by nontraumatic, angiographically negative SAH. Data in this study suggest that familial predisposition may also apply to spontaneous, nonaneurysmal SAH and that family history should be actively investigated in all such patients. The identification of families with multiple affected members could lead to an improved understanding of the genetic and environmental factors associated with this condition.

Familial Predisposition and Differences in Radiographic Patterns in Spontaneous Nonaneurysmal Subarachnoid Hemorrhage

Neurosurgery ◽  
2020 ◽  
Author(s):  
Pui Man Rosalind Lai ◽  
Isaac Ng ◽  
William B Gormley ◽  
Nirav J Patel ◽  
Kai U Frerichs ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Family History ◽  
Clinical Outcome ◽  
Intracranial Aneurysms ◽  
High Rate ◽  
Study Patient ◽  
Familial Predisposition ◽  
History Of ◽  
Nonaneurysmal Subarachnoid Hemorrhage ◽  
Patient Presentation

Abstract BACKGROUND Subarachnoid hemorrhage (SAH) from an intracranial aneurysmal rupture is the most common nontraumatic etiology for SAH, but up to 15% of patients with SAH have no identifiable source. OBJECTIVE To assess familial predisposition to spontaneous nonaneurysmal SAH (naSAH) and to evaluate whether family history affects the severity of presentation and prognosis of this condition. METHODS We conducted a retrospective analysis of all spontaneous SAH with negative digital subtraction angiography from 2004 to 2018. Patients were divided into 2 groups: patients with first- or second-degree relatives with intracranial aneurysms and patients with no family history. Univariate and multivariate regression analyses were used to study patient presentation, radiographic patterns of hemorrhage, and clinical outcome. RESULTS A total of 100 patients met the inclusion criteria. There were no individuals with family history of naSAH. A total of 15 patients (15%) had at least one family member with an intracranial aneurysm, of which 12 (12%) presented as SAH. Patients without family history had a higher percentage of perimesencephalic presentation, whereas those with family history had a higher percentage of nonperimesencephalic SAH presentation (47% vs 13%, odds ratio [OR] 0.17 [95% CI 0.04, 0.81]). CONCLUSION We found a high rate of family history of intracranial aneurysms in patients who presented with naSAH. Although there was no difference in clinical outcome in patients with and without family history, there appears to be a higher percentage of nonperimesencephalic radiographic patterns of SAH in those with family history, suggesting possible different etiologies of these hemorrhages.

GENETIC AND ENVIRONMENTAL FACTORS ASSOCIATED WITH RETICULAR PSEUDODRUSEN IN AGE-RELATED MACULAR DEGENERATION

Retina ◽  
2013 ◽  
Vol 33 (5) ◽  
pp. 998-1004 ◽  
Author(s):  
Nathalie Puche ◽  
Rocio Blanco-Garavito ◽  
Florence Richard ◽  
Nicolas Leveziel ◽  
Jennyfer Zerbib ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Factors Associated ◽  
Reticular Pseudodrusen ◽  
Age Related ◽  
Genetic And Environmental Factors

Invasive Multimodal Neuromonitoring in Aneurysmal Subarachnoid Hemorrhage: A Systematic Review

Stroke ◽  
2021 ◽  
Author(s):  
Michael Veldeman ◽  
Walid Albanna ◽  
Miriam Weiss ◽  
Soojin Park ◽  
Anke Hoellig ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Trend Analysis ◽  
Oxygen Tension ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Delayed Cerebral Ischemia ◽  
Case Series ◽  
Diagnostic Value ◽  
Cerebral Microdialysis ◽  
Treatment Support ◽  
Patients At Risk

Background and Purpose: Aneurysmal subarachnoid hemorrhage is a devastating disease leaving surviving patients often severely disabled. Delayed cerebral ischemia (DCI) has been identified as one of the main contributors to poor clinical outcome after subarachnoid hemorrhage. The objective of this review is to summarize existing clinical evidence assessing the diagnostic value of invasive neuromonitoring (INM) in detecting DCI and provide an update of evidence since the 2014 consensus statement on multimodality monitoring in neurocritical care. Methods: Three invasive monitoring techniques were targeted in the data collection process: brain tissue oxygen tension (p ti O 2 ), cerebral microdialysis, and electrocorticography. Prospective and retrospective studies as well as case series (≥10 patients) were included as long as monitoring was used to detect DCI or guide DCI treatment. Results: Forty-seven studies reporting INM in the context of DCI were included (p ti O 2 : N=21; cerebral microdialysis: N=22; electrocorticography: N=4). Changes in brain oxygen tension are associated with angiographic vasospasm or reduction in regional cerebral blood flow. Metabolic monitoring with trend analysis of the lactate to pyruvate ratio using cerebral microdialysis, identifies patients at risk for DCI. Clusters of cortical spreading depolarizations are associated with clinical neurological worsening and cerebral infarction in selected patients receiving electrocorticography monitoring. Conclusions: Data supports the use of INM for the detection of DCI in selected patients. Generalizability to all subarachnoid hemorrhage patients is limited by design bias of available studies and lack of randomized trials. Continuous data recording with trend analysis and the combination of INM modalities can provide tailored treatment support in patients at high risk for DCI. Future trials should test interventions triggered by INM in relation to cerebral infarctions.

Development of a questionnaire to identify persons with a family history of aneurysmal subarachnoid hemorrhage

2022 ◽  
pp. 174749302110690
Author(s):  
Charlotte CM Zuurbier ◽  
Jacoba P Greving ◽  
Gabriel JE Rinkel ◽  
Ynte M Ruigrok
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Family History ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Positive Family History ◽  
Stroke Patients ◽  
Degree Relative ◽  
First Degree Relatives ◽  
Family History Questionnaire ◽  
Affected Relative ◽  
History Of

Background: Preventive screening for intracranial aneurysms is effective in persons with a positive family history of aneurysmal subarachnoid hemorrhage (aSAH), but for many relatives of aSAH patients, it can be difficult to assess whether their relative had an aSAH or another type of stroke. Aim: We aimed to develop a family history questionnaire for people in the population who believe they have a first-degree relative who had a stroke and to assess its accuracy to identify relatives of aSAH patients. Methods: A questionnaire to distinguish between aSAH and other stroke types (ischemic stroke and intracerebral hemorrhage) was developed by a team of clinicians and consumers. The level of agreement between the questionnaire outcome and medical diagnosis was pilot tested in 30 previously admitted aSAH patients. Next, the sensitivity and specificity of the questionnaire were assessed in 91 first-degree relatives (siblings/children) of previously admitted stroke patients. Results: All 30 aSAH patients were identified by the questionnaire in the pilot study; 29 of 30 first-degree relatives of aSAH patients were correctly identified. The questionnaire had a sensitivity of 97% (95% confidence interval (CI) = 83–100%) and a specificity of 93% (95% CI = 84–98%) when tested in the first-degree relatives of stroke patients. Conclusion: Our questionnaire can help persons to discriminate an aSAH from other types of stroke in their affected relative. This family history questionnaire is developed in the Netherlands but could also be used in other countries after validation.

Factors Associated with Hydrocephalus after Aneurysmal Subarachnoid Hemorrhage

Neurosurgery ◽  
1999 ◽  
Vol 45 (5) ◽  
pp. 1120-1128 ◽  
Author(s):  
Jason P. Sheehan ◽  
Richard S. Polin ◽  
Jonas M. Sheehan ◽  
Mustafa K. Baskaya ◽  
Neal F. Kassell
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Factors Associated

scholarly journals Genetic and Environmental Factors Associated to Glutenin Polymer Characteristics of Wheat

Foods ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 683 ◽  
Author(s):  
Gérard Branlard ◽  
Annie Faye ◽  
Larbi Rhazi ◽  
Ayesha Tahir ◽  
Véronique Lesage ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Grain Protein Content ◽  
Gyration Radius ◽  
Molecular Characteristics ◽  
Climatic Data ◽  
Field Flow Fractionation ◽  
Factors Associated ◽  
Average Temperature ◽  
Genetic And Environmental Factors ◽  
Glutenin Polymer

The polymers of wheat glutenins are studied here using asymmetric flow field flow fractionation (A4F). Molecular mass (Mw), gyration radius (Rw), and the polydispersity index (PI) of polymers were measured over a four-year, multi-local wheat trial in France. The experiment, involving 11 locations and 192 cultivars, offered the opportunity to approach the genetic and environmental factors associated with the phenotypic values of the polymer characteristics. These characteristics, which were all highly influenced by environmental factors, exhibited low broad-sense heritability coefficients and were not influenced by grain protein content and grain hardness. The 31 alleles encoding the glutenin subunits explained only 17.1, 25.4, and 16.8% of the phenotypic values of Mw, Rw, and PI, respectively. The climatic data revealed that a 3.5 °C increase between locations of the daily average temperature, during the last month of the grain development, caused an increase of more than 189%, 242%, and 434% of the Mw, Rw, and PI, respectively. These findings have to be considered in regard to possible consequences of global warming and health concerns assigned to gluten. It is suggested that the molecular characteristics of glutenins be measured today, especially for research addressing non-celiac gluten sensitivity (NCGS).

scholarly journals Identification of Environmental Risk Factors Associated With the Development of Inflammatory Bowel Disease

2020 ◽  
Vol 14 (12) ◽  
pp. 1662-1671
Author(s):  
Kimberley W J van der Sloot ◽  
Rinse K Weersma ◽  
Behrooz Z Alizadeh ◽  
Gerard Dijkstra
Keyword(s):  
Inflammatory Bowel Disease ◽  
Environmental Factors ◽  
Bowel Disease ◽  
Multiple Testing ◽  
Stressful Life Events ◽  
Population Based ◽  
Factors Associated ◽  
Disease Aetiology ◽  
Inflammatory Bowel ◽  
Genetic And Environmental Factors

Abstract Background and Aims Multiple genetic and environmental factors are involved in the aetiology of inflammatory bowel disease [IBD] including Crohn’s disease [CD] and ulcerative colitis [UC], but data on these exposome factors are difficult to identify. Several exposome factors such as smoking have been shown to be involved; as for other environmental factors, eg stress, results have been conflicting. Methods We performed a case-control study including 674 IBD patients of the 1000IBD cohort, frequency-matched based on sex and age with 1348 controls from the population-based Lifelines Cohort Study. Exposome data were obtained using the validated Groningen IBD Environmental Questionnaire [GIEQ], capturing exposome factors through different stages of life using 844 items, of which 454 were applicable to study the role of 93 exposome factors in disease aetiology. Logistic regression [LR] modelling with Bonferroni correction for multiple testing was applied to estimate the multivariable-adjusted effect of each exposome factor. Results For IBD, we identified four novel factors: stressful life events (CD odds ratio [OR] 2.61/UC OR 2.92), high perceived stress [2.29/2.67], alcohol use [0.40/0.43], and bronchial hyper-reactivity [3.04/2.36]. Four novel factors were associated with only CD: prenatal smoke exposure [1.89], having a bed partner [0.53], allergies [2.66], and cow’s milk hypersensitivity [5.87]; and two solely with UC: carpet flooring [0.57] and neuroticism [1.32]. Nine factors were replicated. Conclusions In this study we identified 10 novel, and replicated nine previously reported, exposome factors associated with IBD. Identifying these factors is important for both understanding disease aetiology and future prevention strategies to decrease the development of IBD in genetically susceptible persons.

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