scholarly journals Chronic Q-Fever (Coxiella burnetii) Causing Abdominal Aortic Aneurysm and Lumbar Osteomyelitis: A Case Report

2015 ◽  
Vol 3 (1) ◽  
Author(s):  
P. Alexander Leahey ◽  
Steven R. Tahan ◽  
Ekkehard M. Kasper ◽  
Mary Albrecht
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Coxiella Burnetii ◽  
Q Fever ◽  
Prolonged Treatment ◽  
Chain Reaction ◽  
Abdominal Aortic ◽  
Chronic Q Fever ◽  
Polymerase Chain ◽  
Ig G

Abstract Coxiella burnetii is a rare cause of chronic infection that most frequently presents as endocarditis. We report a case of C burnetii causing an infected abdominal aortic aneurysm with contiguous lumbar osteomyelitis resulting in spinal cord compromise. The diagnosis was established by serologic studies consistent with chronic Q-fever (ratio of C burnetii immunoglobulin [Ig]G phase II titer to IgG phase I titer <1) and was confirmed by positive C burnetii polymerase chain reaction of vertebral tissue in addition to pathology of vertebral bone showing intracellular Gram-negative coccobacillary bacteria. The patient clinically improved after surgical decompression and prolonged treatment with doxycycline and hydroxychloroquine.

A Case of Primary Aortoduodenal Fistula and Abdominal Aortic Aneurysm in a Patient with Chronic Q-fever

Aorta ◽  
2017 ◽  
Vol 5 (1) ◽  
pp. 27-29 ◽  
Author(s):  
Arne de Niet ◽  
Ignace F.J. Tielliu ◽  
Paul M. van Schaik ◽  
Jan J.A.M. van den Dungen ◽  
Clark J. Zeebregts
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Q Fever ◽  
Aortoduodenal Fistula ◽  
Abdominal Aortic ◽  
Chronic Q Fever

scholarly journals Chronic Q Fever in Alberta: A Case ofCoxiella burnetiiMycotic Aneurysm and Concomitant Vertebral Osteomyelitis

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
William Stokes ◽  
Jack Janvier ◽  
Stephen Vaughan
Keyword(s):  
Coxiella Burnetii ◽  
Vascular Tissue ◽  
Open Repair ◽  
Q Fever ◽  
Vertebral Osteomyelitis ◽  
Abdominal Aortic ◽  
Chronic Q Fever ◽  
Life Threatening ◽  
History Of ◽  
Polymerase Chain

Chronic Q fever is a potentially life-threatening infection from the intracellular, Gram-negativeCoxiella burnetii. It presents most commonly as endocarditis or vascular infection in people with underlying cardiac or vascular disease. We discuss a case of a 67-year-old male withCoxiella burnetiivascular infection of a perirenal abdominal aortic graft. The patient had a history of an abdominal aortic aneurysm (AAA) repair 5 years earlier. He presented with a 12 × 6 × 8 cm perirenal pseudoaneurysm and concomitant L1, L2, and L3 vertebral body discitis. He underwent an open repair which revealed a grossly infected graft perioperatively. Q fever serology revealed phase I serological IgG titer of 1 : 2048 and phase II 1 : 1024 consistent with chronic Q fever. Polymerase chain reaction (PCR) on infected vascular tissue was positive forC. burnetii. The patient was started on doxycycline and hydroxychloroquine with good clinical response and decreasing serological titers. Recognizing chronic Q fever is a difficult task as symptoms are nonspecific, exposure risk is difficult to ascertain, and diagnosis is hidden from conventional microbiological investigations. Its recognition, however, is critical asC. burnetiiis inherently resistant to standard empiric therapies used in cardiovascular infections.

scholarly journals A Case of Primary Aortoduodenal Fistula and Abdominal Aortic Aneurysm in a Patient with Chronic Q Fever

Aorta ◽  
2017 ◽  
Vol 05 (01) ◽  
pp. 27-29
Author(s):  
Arne de Niet ◽  
Ignace Tielliu ◽  
Paul van Schaik ◽  
Jan van den Dungen ◽  
Clark Zeebregts
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Medical Treatment ◽  
Causative Agent ◽  
Q Fever ◽  
Aortoduodenal Fistula ◽  
Abdominal Aortic ◽  
Chronic Q Fever ◽  
History Of

AbstractA 70-year-old man was successfully treated for an aortoduodenal fistula originating from a Q fever-related abdominal aortic aneurysm. He had no known history of contact with cattle or sheep. Although the combination of abdominal aortic aneurysm and aortoduodenal fistula is rare, one should be suspicious of Q fever infection as the causative agent, and additional medical treatment should be initiated.

miR-33-5p knockdown attenuates abdominal aortic aneurysm progression via promoting target adenosine triphosphate-binding cassette transporter A1 expression and activating the PI3K/Akt signaling pathway

Perfusion ◽  
2019 ◽  
Vol 35 (1) ◽  
pp. 57-65 ◽  
Author(s):  
Lingfeng Zhao ◽  
Jian Huang ◽  
Yancui Zhu ◽  
Shengbin Han ◽  
Kaixiong Qing ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Reverse Transcription ◽  
Cholesterol Efflux ◽  
Akt Signaling Pathway ◽  
Chain Reaction ◽  
Abdominal Aortic ◽  
Abca1 Expression ◽  
Polymerase Chain

Purpose: The aim of this study was to investigate the role of miR-33-5p in abdominal aortic aneurysm progression, which regulated adenosine triphosphate-binding cassette transporter A1 (ABCA1)-mediated cholesterol efflux and lipid accumulation in THP-1 macrophage-derived foam cells through the PI3K/Akt pathway. Methods: Quantitative reverse transcription polymerase chain reaction was used to evaluate the expression level of miR-33-5p and ABCA1 mRNA in abdominal aortic aneurysm patient and normal person tissues. The relationship between miR-33-5p and ABCA1 was examined by dual luciferase report assay. High-performance liquid chromatography was used to evaluate the levels of cholesterol contents. Cholesterol efflux detection was performed by liquid scintillator. The expression of inflammatory cytokines was detected by quantitative reverse transcription polymerase chain reaction. Western blot was applied to determine the expression levels of ABCA1, PI3K (p-PI3K), and Akt (p-Akt). Results: The quantitative reverse transcription polymerase chain reaction analysis results revealed miR-33-5p overexpression in abdominal aortic aneurysm tissues, but the expression level of ABCA1 was lower in abdominal aortic aneurysm tissues than non-abdominal aortic aneurysm tissues. Subsequently, the dual luciferase report gene assay confirmed that ABCA1 was a target of miR-33-5p, and miR-33-5p-negative regulated ABCA1 expression. Moreover, the expression levels of p-PI3K, p-Akt, and ABCA1 were decreased in THP-1 cell transferred with ABCA1 siRNA, but knockdown of miR-33-5p had an opposite effect. Furthermore, knockdown of miR-33-5p decreased the expression of MMP-2, MMP-9, TNF-α, total cellular cholesterol, and promoted cholesterol efflux in THP-1-derived foam cells. Importantly, LY294002 (PI3K inhibitor) or si-ABCA1 completely inhibited the stimulatory effects of miR-33-5p inhibitor. Conclusion: This study has found that knockdown of miR-33-5p induced ABCA1 expression and promoted inflammatory cytokines and cholesterol efflux likely via activating the PI3K/Akt signaling pathway.

scholarly journals Chronic Q Fever with Vascular Involvement: Progressive Abdominal Pain in a Patient with Aortic Aneurysm Repair in the United States

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Zanthia Wiley ◽  
Sujan Reddy ◽  
Kara M. Jacobs Slifka ◽  
David C. Brandon ◽  
John Jernigan ◽  
...  
Keyword(s):  
United States ◽  
Abdominal Pain ◽  
Aortic Aneurysm ◽  
Coxiella Burnetii ◽  
Q Fever ◽  
Antibody Detection ◽  
Vascular Involvement ◽  
Chronic Q Fever ◽  
Aneurysm Repair ◽  
Aortic Aneurysm Repair

Q fever is a zoonotic bacterial infection caused by Coxiella burnetii. Chronic Q fever comprises less than five percent of all Q fever cases and, of those, endocarditis is the most common presentation (up to 78% of cases), followed by vascular involvement. Risk factors for chronic Q fever with vascular involvement include previous vascular surgery, preexisting valvular defects, aneurysms, and vascular prostheses. The most common symptoms of chronic Q fever with vascular involvement are nonspecific, including weight loss, fatigue, and abdominal pain. Criteria for diagnosis of chronic Q fever include clinical evidence of infection and laboratory criteria (antibody detection, detection of Coxiella burnetii DNA, or growth in culture). Treatment of chronic Q fever with vascular involvement includes a prolonged course of doxycycline and hydroxychloroquine (≥18 months) as well as early surgical intervention, which has been shown to improve survival. Mortality is high in untreated chronic Q fever. We report a case of chronic Q fever with vascular involvement in a 77-year-old man with prior infrarenal aortic aneurysm repair, who lived near a livestock farm in the southeastern United States.

Primary aortoduodenal fistula and chronic Q fever infection

2021 ◽  
Vol 14 (2) ◽  
pp. e238373
Author(s):  
Cuong Nghi Do ◽  
Ethan Oskar Mar ◽  
Beatrice Sim ◽  
David Looke
Keyword(s):  
Risk Factors ◽  
Abdominal Aortic Aneurysm ◽  
Q Fever ◽  
Case Reports ◽  
Successful Outcome ◽  
Aortoduodenal Fistula ◽  
Abdominal Aortic ◽  
Chronic Q Fever ◽  
Definitive Surgery ◽  
Animal Reservoirs

We report a case of chronic Q fever presenting with catastrophic bleeding from an infected abdominal aortic aneurysm causing a primary aortoduodenal fistula in an 80-year-old retired farmer. This presentation is rarely reported in literature and only through case reports. Early diagnosis and definitive surgery were critical to a successful outcome. Serological diagnosis of Q fever was initiated on the patient’s past exposure to animal reservoirs. Complicating the case was ongoing gastrointestinal bleeding postsurgery, with multiple endoscopies undertaken before a culprit remnant fistula was found. This case highlights the value in considering Coxiella burnetii as an underlying cause in patients with known risk factors presenting with primary aortoduodenal fistulas. Though rare, it represents a readily treatable cause.

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