scholarly journals Vitamin D and Acute Respiratory Infections—The PODA Trial

2019 ◽  
Vol 6 (9) ◽  
Author(s):  
John F Aloia ◽  
Shahidul Islam ◽  
Mageda Mikhail
Keyword(s):  
Vitamin D ◽  
African American ◽  
Placebo Group ◽  
African American Women ◽  
Physical Performance ◽  
Respiratory Infections ◽  
Vitamin D Supplementation ◽  
Acute Respiratory Infections ◽  
American Women ◽  
Older African American Women

Abstract Background There is considerable heterogeneity in clinical trials examining the role of vitamin D in the prevention of acute respiratory infections (ARIs). Methods The primary aim of the Physical Performance, Osteoporosis, and Vitamin D in Older African-American Women (PODA) trial was the prevention of bone loss and decline in physical performance. A questionnaire about ARIs was administered every 3 months for 3 years to 260 black American women in a double-blind randomized clinical trial that had a placebo group and a vitamin D supplementation group. The serum 25(OH)D level was maintained >30 ng/mL in the vitamin D group. Results Serum 25(OH)D was maintained >30 ng/mL in 90% of the active group, whereas levels approximated those associated with the recommended dietary allowance (20 ng/mL) in the placebo group. There was no difference in occurrence of ARIs in the treatment group vs the placebo group. ARIs were not related to total or free 25(OH)D, which were measured at baseline and annually for 36 months. Conclusions Vitamin D supplementation sufficient to maintain serum 25(OH)D >30 ng/mL does not prevent ARIs in older African American women. ClinicalTrials.gov Registration Number NCT01153568.

scholarly journals Effects of Vitamin D Supplementation in Older African American Women

2013 ◽  
Vol 98 (3) ◽  
pp. 1137-1146 ◽  
Author(s):  
J. Christopher Gallagher ◽  
Munro Peacock ◽  
Vinod Yalamanchili ◽  
Lynette M. Smith
Keyword(s):  
Vitamin D ◽  
African American ◽  
African American Women ◽  
Vitamin D Supplementation ◽  
American Women ◽  
Older African American Women

scholarly journals Vitamin D Supplementation in Young White and African American Women

2013 ◽  
Vol 29 (1) ◽  
pp. 173-181 ◽  
Author(s):  
J Christopher Gallagher ◽  
Prachi S Jindal ◽  
Lynette M Smith
Keyword(s):  
Vitamin D ◽  
African American ◽  
African American Women ◽  
Vitamin D Supplementation ◽  
American Women

scholarly journals Dose response to vitamin D supplementation among postmenopausal African American women

2007 ◽  
Vol 86 (6) ◽  
pp. 1657-1662 ◽  
Author(s):  
Sonia A Talwar ◽  
John F Aloia ◽  
Simcha Pollack ◽  
James K Yeh
Keyword(s):  
Vitamin D ◽  
African American ◽  
African American Women ◽  
Dose Response ◽  
Vitamin D Supplementation ◽  
American Women

scholarly journals Physical Performance Is Associated with Executive Functioning in Older African American Women

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Brooke C. Schneider ◽  
Peter A. Lichtenberg
Keyword(s):  
African American ◽  
Executive Functioning ◽  
Lower Extremity ◽  
African American Women ◽  
Physical Performance ◽  
Block Design ◽  
Demographic Variables ◽  
American Women ◽  
Older African American Women ◽  
Trail Making

An older adult's ability to perform physical tasks is predictive of disability onset and is associated with declines in cognition. Risk factors for physical performance declines among African Americans, a group with the highest rates of disability, remain understudied. This study sought to identify demographic, health, and cognitive factors associated with lower-extremity physical performance in a sample of 106 African American women ages 56 to 91. After controlling for global cognitive functioning (Mini Mental State Exam), physical performance was associated with executive functioning (Stroop Color/Word), but not visuospatial construction (WASI Block Design) or processing speed (Trail Making Test, Part A). Executive functioning remained associated with physical performance after entry of demographic variables, exercise, depression, disease burden, and body mass index (BMI). Age, and BMI were also significant in this model. Executive functioning, age and BMI are associated with lower-extremity physical performance among older African American women.

Vitamin D and Falls in Older African American Women: The PODA Randomized Clinical Trial

2019 ◽  
Vol 67 (5) ◽  
pp. 1043-1049 ◽  
Author(s):  
John F. Aloia ◽  
Rakhil Rubinova ◽  
Melissa Fazzari ◽  
Shahidul Islam ◽  
Mageda Mikhail ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Vitamin D ◽  
African American ◽  
African American Women ◽  
Randomized Clinical Trial ◽  
American Women ◽  
Older African American Women

scholarly journals Vitamin D and Abdominal Aortic Calcification in Older African American Women, the PODA Clinical Trial

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 861 ◽  
Author(s):  
Saloni Brahmbhatt ◽  
Mageda Mikhail ◽  
Shahidul Islam ◽  
John F. Aloia
Keyword(s):  
Clinical Trial ◽  
Vitamin D ◽  
African American ◽  
Placebo Group ◽  
African American Women ◽  
Aortic Calcification ◽  
Vertebral Fracture Assessment ◽  
Abdominal Aortic Calcification ◽  
American Women ◽  
Abdominal Aortic

Abdominal aortic calcification (AAC) detected on lateral vertebral fracture assessment is associated with increased cardiovascular risk. Vitamin D deficiency and toxicity have been linked with vascular calcification. The objective of this study was to determine the effect of high-dose vitamin D on the progression of AAC. The Physical Performance, Osteoporosis and vitamin D in African American Women (PODA) is a randomized, clinical trial examining the effect of vitamin D. There were 14.7% subjects with AAC in the vitamin D group, compared to 12.1% in the placebo group at baseline. The prevalence of extended AAC at baseline was 6.4% in the vitamin D group and 3.5% in the placebo group. The extended calcification scores over time were not different between groups. There was no association between AAC and serum 25(OH)D. However, PTH was associated with an increase in AAC in the placebo group.

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