Intermirochondrial Filamentous Structures in Human Reticulum Cells in the Bine Marrow

Keyword(s):  
2014 ◽  
Vol 210 (12) ◽  
pp. 1167-1170
Author(s):  
Dimas Suárez-Vilela ◽  
Francisco Miguel Izquierdo ◽  
Jose Ramón Riera-Velasco ◽  
Patricia Morales-del Burgo

PEDIATRICS ◽  
1962 ◽  
Vol 30 (4) ◽  
pp. 595-600
Author(s):  
Stanley E. Crawford ◽  
Chester K. Jones

The findings in a fatal case of liver necrosis in a child given diphenylhydantoin sodium are presented. Typical lymph node hyperplasia of the reticulum cells, with mitotic figures and eosinophils, were seen in this instance. These are a well-documented finding in hypersensitivity to this drug.


Blood ◽  
1985 ◽  
Vol 66 (5) ◽  
pp. 1092-1097
Author(s):  
GS Wood ◽  
CF Garcia ◽  
RF Dorfman ◽  
RA Warnke

Follicle lysis is a characteristic alteration of B cell follicles described recently in lymph node biopsies from homosexual men. It consists of disruption of germinal centers by aggregates of small mature lymphocytes variably associated with erythrocyte extravasation. We studied the immunohistology of follicle lysis identified in lymph node biopsies from 11 homosexual men. The results indicate that follicle lysis has two principal immunohistologic features: (1) intrafollicular aggregates of small lymphocytes predominantly of polytypic mantle B cell phenotype (T015+/Leu-8+/mu+/delta+/k+ or lambda+), and (2) disruption of the normal, unified follicular meshwork of R4/23+ dendritic reticulum cells by these B cell aggregates. These structural alterations may affect the functional integrity of the germinal center as it pertains to the abnormal B cell effector function and the increased prevalence of B cell lymphoma recently documented in the acquired immunodeficiency syndrome and related disorders. Because dendritic reticulum cells weakly express the Leu-3 (T4) antigen, which is known to be an essential component of the receptor for human T- lymphotropic virus type III/lymphadenopathy-associated virus (HTLV- III/LAV) retrovirus infection, it is possible that retroviral infection of dendritic reticulum cells may play a role in the pathogenesis of follicle lysis.


Cancer ◽  
1987 ◽  
Vol 60 (12) ◽  
pp. 2919-2926 ◽  
Author(s):  
Antonino Carbone ◽  
Alessandro Poletti ◽  
Riccardo Manconi ◽  
Annunziata Gloghini ◽  
Rachele Volpe

Blood ◽  
1966 ◽  
Vol 27 (2) ◽  
pp. 212-226 ◽  
Author(s):  
JORGE E. MALDONADO ◽  
ROBERT A. KYLE ◽  
ARNOLD L. BROWN ◽  
EDWIN D. BAYRD

Abstract Bone marrow studies of multiple myeloma revealed, in some cases, a conspicuous proliferation of "lymphoid" cells, virtually indistinguishable by light microscopy from those seen in lympho-proliferative disorders. Electron microscopy demonstrated a variety of cells ranging from typical lymphocytes to cells with plasmocytoid features. Between these two types of elements there were cells with intermediate characteristics. In addition, in several cases of myeloma the presence of fixed reticuloendothelial cells and "reticular" plasma cells (or reticulum cells with plasmocytic features) was frequently noted. The presence of reticulum cells and lymphocytes and of cells apparently "intermediate" between these cellular elements and plasma cells, as judged from electron microscopic observations, is suggestive morphologic evidence of a phenomenon of cell transformation and evidence of a mixed cell proliferation in certain cases of multiple myeloma.


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