Abstract
Introduction
Light exposure has powerful effects on the circadian timing of sleep and wake, primarily through the regulation of the secretion of melatonin. However, it is becoming clear that light has additional alerting effects beyond its primary effect on the circadian system. Exposure to light, particularly blue-wavelength light, has been shown to acutely increase brain activation, alertness, and some elementary aspects of cognitive performance such as working memory and emotional anticipation during the day. Whether blue light exposure can have longer-lasting effects on brain activation and performance during more complex cognitive control tasks up to 30-minutes after light cessation is unknown.
Methods
In a sample of 30 healthy adults, we examined the effects of a single 30-minute exposure to either blue (n=14) or amber placebo (n=16) light on subsequent brain activation and performance during the Multi-Source Interference Task (MSIT) measured a half-hour after light cessation using functional magnetic resonance imaging. Mean activation in all regions showing increased task-related activation (i.e., Task Positive Network; TPN) and regions showing decreased activation (i.e., Default Mode Network; DMN) at p<.001 (FWE corrected) was extracted separately for each network in SPM12 and compared between light conditions.
Results
Performance metrics for the MSIT, including accuracy, response time, and cognitive throughput, did not differ between the blue and amber conditions, suggesting that performance was sustained equally between light conditions. However, brain activation within the TPN to the interference condition of the MSIT was significantly lower (p=.024) in the blue relative to the amber condition, with no group differences observed for suppression of the DMN.
Conclusion
Compared to amber, a single exposure to blue light was associated with enhanced neural efficiency a half-hour later as demonstrated by reduced TPN activation to achieve the same level of cognitive performance. Blue light may be an effective method for optimizing neurocognitive performance under some conditions.
Support
US Army Medical Research and Materiel Command: W81XWH-14-1-0571