scholarly journals Sildenafil versus Nifedipine Treatment of PRETERM LABOR: RCT

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M A Alkady ◽  
M H Mostafa ◽  
R K Elkattan
Keyword(s):  
Preterm Labor ◽  
Normal Pregnancy ◽  
The United States ◽  
Labor Pain ◽  
University Hospital ◽  
P Value ◽  
Term Pregnancy ◽  
Premature Rupture ◽  
Preterm Premature Rupture ◽  
Future Therapy

Abstract Background a normal pregnancy lasts 37 to 42 weeks, counting from the first day of the last menstrual period. A pregnancy that continues beyond 37 weeks is called a “term” pregnancy. Preterm labor is defined as labor that begins before 37 weeks of pregnancy. Approximately 12 percent of babies in the United States are born preterm; 80 percent of these are due to preterm labor that occurs on its own or after preterm premature rupture of the fetal membranes (or “broken bag of waters”). The remaining 20 percent are planned early deliveries that are done for maternal or fetal problems that prevent the woman from being able to safely continue with her pregnancy. Aim of the Work to assess the efficacy of sildenafil for stopping the labor for 48 hrs compared to nifedipine in women with preterm labor. Patients and Methods this prospective study was carried on pregnant women with preterm labor pain at Ain Shams University Hospital from March 2018 till September 2018. Study includes 88 patients which were distributed into two groups: Group S: received Sildenafil to stop preterm labor.Group N: received Nifedipine to stop preterm labor. Results in the present study we found that mean age in group receiving sildenafil (group S) was 26.55 years and in group receiving nifidpine (group N) was 26.75 years with insignificant differences between two groups as regard age p-value 0.798, also as regard. BMI and parity there was insignificant differences between two groups as regard BMI p-value 0.727, 0.815 respectively, Mean Gestational age at admission was 27.1 weeks in group S and in group N was 28.16 with insignificant differences between two groups p-value 0.705. Conclusion administration of Sildenafil in women with preterm labor pain seems to be a promising future therapy of preterm labor with, limiting the teratogenic influence of the drugs on the fetus.

scholarly journals Bacterial vaginosis as a risk factor of preterm premature rupture of membrane (PPROM)

2019 ◽  
Vol 1 (2) ◽  
Author(s):  
Aanak Agung Gde Putra Wiraguna ◽  
Luh Made Mas Rusyati ◽  
I Dewa Ayu Vanessa Vijayamurthy
Keyword(s):  
Risk Factor ◽  
Bacterial Vaginosis ◽  
Control Method ◽  
Fibrous Tissue ◽  
Normal Pregnancy ◽  
Average Score ◽  
Premature Rupture ◽  
Preterm Premature Rupture ◽  
Increased Risk ◽  
Risk Of Rupture

Introduction: The pathogenesis of PPROM is complex and not fully understood. Recent studies showed that such role of genital tract infection as bacterial vaginosis in the pathogenesis of PPROM turned out to be present. They produce lipase enzymes in which they can form compounds with the fibrous tissue of amniotic membrane resulting in increased risk of rupture of the membrane.Objective This study aims to prove that bacterial vaginosis is a risk factor for preterm premature rupture of membrane.Material and methods: This research used case control method. Sampling was using the consecutive sampling method and had fulfilled inclusion and exclusion criteria with age-based matching, then vaginal swab sampling was conducted, painted with gram staining in the Dermalotogy and Venereology Laboratory of Sanglah Hospital, and Nugent score.Result: Total of 76 pregnant women with 24-36 weeks of gestation were investigated, 38 mothers with PPROM and 38 mothers with normal pregnancy. Average score of Nugent at preterm PROM was 7.18 and in normal pregnancy was 2.37. Bacterial vaginosis risking for PPROM 7 times (OR= 7.0, 95% CI= 1.21-17.68, p= 0.001).Conclusion: Bacterial vaginosis as a risk factor for the occurrence of PPROM.

scholarly journals Pregnancy Outcome in Uterine Anomalies

2017 ◽  
Vol 3 (1) ◽  
pp. 31-33
Author(s):  
Nagendra Prasad ◽  
James Thingujam
Keyword(s):  
Retrospective Study ◽  
Pregnancy Outcome ◽  
Pregnancy Outcomes ◽  
Intrauterine Growth Restriction ◽  
Preterm Labor ◽  
Premature Rupture ◽  
Intrauterine Growth ◽  
Preterm Premature Rupture ◽  
Uterine Anomalies ◽  
Uterine Anomaly

ABSTRACT Maternal with congenitial anomalies are known to have higher incidence of infertility, intrauterine growth restriction, fetal malposition, preterm labor, preterm premature rupture of membrane and increased cesaerean section rate. Study Design This is retrospective study, the pregnancies with uterine anomaly confirmed by ultrasound between Jan 2016 to jan 2017 at our hospital was taken and its outcome is observed. Reults The majority of preterm delivery in our study are mainly associated with septate and bicornuate uterus. Cesaerean section comprised of 80% and its major indication is due to fetal malpresentation (breech). Thus Pregnancy outcomes of individual depending on the type of uterine anomalies. How to cite this article Nagarathnamma R, James T, Prasad N. Pregnancy Outcome in Uterine Anomalies. J Med Sci 2017;3(1):31-33.

scholarly journals Obstetric Management of Copperhead Snake Envenomation in Pregnancy: A Case Report

2019 ◽  
Vol 2 (2) ◽  
pp. 35-41
Author(s):  
Michelle J. Wang ◽  
Michelle Y. Lu ◽  
Elizabeth B. Ausbeck ◽  
Lorie M. Harper
Keyword(s):  
Case Report ◽  
Preterm Labor ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Fetal Outcomes ◽  
Snake Envenomation ◽  
Preterm Premature Rupture ◽  
Antenatal Steroids ◽  
Obstetric Management ◽  
In Pregnancy

Snakebites in pregnancy can result in significant maternal and fetal harm; however, the literature to guide management of this rare obstetric complication remains limited. We describe our approach to envenomation in pregnancy based on the currently available evidence. A 27-year-old G2P1 female presented at 27 weeks’ gestation after suffering a copperhead snakebite. She received antivenom and antenatal steroids without adverse maternal or fetal event. Antenatal testing was reassuring throughout admission, and she was discharged home with plans for close outpatient surveillance. She later developed preterm premature rupture of membranes and preterm labor, with delivery of a live infant at 33 weeks’ gestation. The risk of adverse maternal and fetal outcomes following snake envenomation in pregnancy may warrant closer antenatal surveillance than has been previously described.

The relationship between oligohydramnios and the onset of preterm labor in preterm premature rupture of membranes

2001 ◽  
Vol 184 (3) ◽  
pp. 459-462 ◽  
Author(s):  
Joong Shin Park ◽  
Bo Hyun Yoon ◽  
Roberto Romero ◽  
Jeong Bin Moon ◽  
Soo-Young Oh ◽  
...  
Keyword(s):  
Preterm Labor ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Preterm Premature Rupture ◽  
The Relationship

scholarly journals Are maternal metabolic syndrome and lipid profile associated with preterm delivery and preterm premature rupture of membranes?

2019 ◽  
Author(s):  
Lida Moghaddam-Banaem ◽  
Shiva Niyaty ◽  
Hadis Sourinejad ◽  
Samira Mokhlesi
Keyword(s):  
Metabolic Syndrome ◽  
Lipid Profile ◽  
Preterm Delivery ◽  
Challenge Test ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
P Value ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Preterm Premature Rupture

Abstract Objectives We aimed to evaluate the association of metabolic syndrome (MetS), its components and lipid profile in mid-pregnancy with preterm delivery and preterm premature rupture of membranes (PPROM).Methods This prospective cohort study was conducted on 203 pregnant women between 24-28 weeks of gestation, undergoing the gestational diabetes screening test with 50 gr glucose challenge test (GCT). Fasting serum total cholesterol, low-density lipoprotein cholesterol (LDL-C), high -density lipoprotein cholesterol (HDL-C), and triglyceride (TG) levels were measured during the week after GCT assessment. Information on the participants' pre-pregnancy weight, demographic/ reproductive characteristics, and height and blood pressure (BP) measurements were documented at baseline entry into the study. Metabolic syndrome was defined as the co-existence of 3 or more of the following criteria: Body mass index (BMI) before pregnancy≥30 kg/m2, BP≥130/85 mmHg, GCT≥140mg/dl, TG≥150mg/dl, and HDL-C≤50mg/dl. All participants were followed through routine prenatal care, up to delivery. Any deliveries or rupture of membranes of less than or equal to weeks of pregnancy, were considered preterm delivery and PPROM respectively. Statistical analysis was performed by SPSS V.20, and p-value of less than 0.05 was considered significant.Results MetS was detected in 10 (4.9%) of participants. Logistic regression analysis showed HDL-C levels, and hypertension had significant effects on preterm delivery occurrence [(OR: 0.952, 95%CI: 0.910_0.995), (OR: 1.629, 95% CI: 1.554_1.709) respectively], but no statistically significant results were found for PPROM.Conclusions Low HDL-C levels and hypertension in mid-pregnancy may increase the occurrence of preterm deliveries, indicating that MetS and its components should be monitored more closely in pregnancy.

Good clinical practice advice: Prediction of preterm labor and preterm premature rupture of membranes

2019 ◽  
Vol 144 (3) ◽  
pp. 340-346 ◽  
Author(s):  
◽  
Gian Carlo Di Renzo ◽  
Eduardo Fonseca ◽  
Eduardo Gratacos ◽  
Sonia Hassan ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Preterm Labor ◽  
Good Clinical Practice ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Preterm Premature Rupture
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