Usefulness of AF Lactoferrin Levels in Patients with Liver Cirrhosis to Diagnose Spontaneous Bacterial Peritonitis

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Tarek Mohamed Youssef ◽  
Ahmed El Saady Mohmmed Khyal ◽  
Mohamed Magdy Salama ◽  
Elary Abdel Maseeh Poles
Keyword(s):  
Liver Cirrhosis ◽  
Spontaneous Bacterial Peritonitis ◽  
Chronic Liver ◽  
Control Group ◽  
Time Saving ◽  
Bacterial Peritonitis ◽  
Bedside Test ◽  
Significant Difference ◽  
Child Class ◽  
Department Faculty

Abstract Background Cirrhosis represents the final common histological pathway for a wide variety of chronic liver diseases. Occurrence of ascites is the most common presentation of liver cirrhosis. Spontaneous bacterial peritonitis (SBP) is observed in 15–26% of patients hospitalized with ascites. Objectives The aims of this study was to evaluate the usefulness of AF lactoferrin for the diagnosis of SBP and to identify a clinically useful cut-off level that can be used for future development of an important clinical, economic and time saving rapid bedside test for the diagnosis of SBP in cirrhotic ascites. Patients and Methods This study was conducted on 40 patients with decompensated chronic liver disease and ascites with and without spontaneous bacterial peritonitis admitted to Nasser institute for researches and treatment Hospital and Internal Medicine department, Faculty of Medicine, Ain Shams University from November 2017 to April 2018. Results Females were affected more than males by SBP, SBP has higher incidence in elderly compared to control group, no significant difference between studied groups regards to risk factors and Child class, HCV infection was the main etiology of liver cirrhosis in both groups while HBV infection was much less common with no significant difference between studied groups. Patients in SBP group showed positive reaction to CRP compared to control group with significant difference between them. No statistical significant differences between studied groups regards to abdominal ultrasonographic findings. Liver enzymes (ALT) and ALP were higher in SBP patients compared to non SBP patients with significant difference between them. SBP patients have higher TLC and lower MCV and platelets count compared to non SBP patients with significant difference between them. No statistical significant difference between studied groups regards to INR, Hb and MCH values. Conclusion Outcomes of our study provide evidence of the clinical usefulness of AF lactoferrin levels in patients with cirrhosis to differentiate those with and without SBP.

scholarly journals The study of prognostic factors in resistant spontaneous bacterial peritonitis in cirrhotic patients

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
K M Abdelwahab ◽  
W A Yousry ◽  
K A Mansour ◽  
S G Mohammed
Keyword(s):  
Prognostic Factors ◽  
Spontaneous Bacterial Peritonitis ◽  
Meld Score ◽  
Antimicrobial Treatment ◽  
Control Group ◽  
P Value ◽  
Line Treatment ◽  
Bacterial Peritonitis ◽  
Fluid Analysis ◽  
Significant Difference

Abstract Background Spontaneous Bacterial Peritonitis is the most common form of infection seen in-patient with cirrhosis and is responsible of hospital mortality rate of approximately 32%, the increasing trend of resistance associated with low treatment efficacy of traditional therapy in nosocomial infection. It has been considered a life-threatening infection that requires a prompt diagnosis and treatment. Aim To evaluate the effect of certain prognostic factors namely Child -Pugh score, MELD Score and isolated organisms by bacterial cultures & Identifying organisms responsible for resistant SBP will guide in modification of antimicrobial treatment regimen. Methods A prospective cohort Study was conducted on 100 Egyptian cirrhotic and Ascetic patients for whom suspected for Spontaneous bacterial peritonitis (SBP) with no prior antimicrobial treatment. SBP and RSBP(Resistant spontaneous bacterial peritonitis) was diagnosed through history-taking through examination, clinical assessment and laboratory investigations, including ascetic fluid study analysis and the detection of culture sensitivity, recruited from the Gastrointestinal and Hepatology Unit of Nasser Institute Hospital, over a period from December 2016 to April 2017. Results Our study showed that out of 100 cirrhotic and Ascetic, out of 100; 60 were diagnosed SBP, out of those 60 resistant SBP were diagnosed in 30 patients with culture positive that responded on 2nd line treatment; Meropenem; 1g IV (with dose modification according creatinine clearance level) every 8 h for 5 days are the cases group and remained 30 that respond on the usual 1st line treatment; 2g of intravenous (IV) Cefotaxime (CTX) every 8h for 5days; are the control group. We found that there was no statistical significant difference between the studied groups as regards age and sex, Fever and abdominal pain were the most frequent manifestations in both group. There was statistically significant difference between both groups according to the grade of Ascites, Hepatic encephalopathy and at the peritoneal fluid analysis after 48 h of 2 gram of CTX for TLC and Neutrophil & also Cl, Glucose and LDH (P value<0.05). The RSBP prediction by Child score at cut off value ≥9.5 and the most frequent organism is Klebsiella in cultures results among RSBP which is being responded on Meropenem treatment. Conclusion RSBP associated with child c patients at cut off value≥9.5 so Child score is more useful as prognostic tool than MELD score although MELD score has higher accuracy prediction than Child score because it is vulnerable in Laboratory measurement.

scholarly journals The validity of Triggering Receptor Expressed on Myeloid Cells (TREM-1) in diagnosis of Spontaneous Bacterial Peritonitis in cirrhotic patients

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
W Abdelmonsef ◽  
N A Abdelkader ◽  
G A Ismail ◽  
M M Elgaafary ◽  
Y A Abdelrazek
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Ascitic Fluid ◽  
Spontaneous Bacterial Peritonitis ◽  
Chronic Liver ◽  
Statistical Significant Difference ◽  
Bacterial Peritonitis ◽  
Significant Difference ◽  
Cirrhotic Patients ◽  
The Mean

Abstract Background Spontaneous bacterial peritonitis (SBP) is a serious complication in cirrhotic patients with ascites. Without early antibiotic treatment, this complication is associated with a 30-50% mortality rate. Recently we have evaluated the validity and utility of ascitic fluid triggering receptors expressed on myeloid cells-1 (TREM-1) levels for the diagnosis of SBP. Patients and Methods This was a Prospective case control study conducted on 60 patients with chronic liver disease and ascites divided into two group, group 1 (control) 30 patients without SBP and group 2 (SBP) 30 patients, admitted to the Tropical Medicine Department with ascites due to chronic liver disease. All patients were subjected to full history taking and clinical examination full laboratory investigations including complete blood picture liver and renal profiles, C reactive protein, viral markers, abdominal ultrasound, UGI endoscopy and ascitic fluid sampling for biochemical testing, total and differential cell count, microbiological culture and TREM-1 level. Results There was high statistical significant difference between the two groups in the base level of TREM-1 in which the mean was 1280 pg/ml (1136.9) with level range between (580---4500pg/ml) in SBP versus mean 129.9 pg/ml (51.9) with level range between (60-250pg/ml) in the control group. Also there was a statistical significant difference in the level of TREM-1 before and after treatment in the SBP patients in which the mean of TREM-1 before treatment was 1280.6 pg/ml (1136.9) with level range between (580-4500pg/ml) versus mean 376.2 pg/ml (78.4) and level range between (260-560 pg/ml) after the treatment. Conclusion our data indicate that the measurement of ascitic fluid TREM-1 is rapid, easy and valid test in the diagnosis and follow up of chronic liver disease patients with SBP.

scholarly journals Assessment of serum 25-hydroxy vitamin D in cirrhotic patients with and without spontaneous bacterial peritonitis (SBP)

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
S M Shalaby ◽  
E M Baiumy ◽  
M G Abdelrahman ◽  
M M Sayed ◽  
R M Abdelhalim ◽  
...  
Keyword(s):  
Vitamin D ◽  
Liver Cirrhosis ◽  
Bacterial Infections ◽  
Spontaneous Bacterial Peritonitis ◽  
Complete Blood Count ◽  
Decompensated Cirrhosis ◽  
Bacterial Peritonitis ◽  
Significant Difference ◽  
Cirrhotic Patients ◽  
25 Oh Vitamin D

Abstract Background Vitamin D has pleotropic effect including the immune function, it increases innate immunity and modifies lymphocyte activation. The risk for bacterial infections is increased in cirrhotic patients due to low levels of vitamin D, so its deficiency may be linked with the prevalence of SBP in cirrhotic patients Aim of the work To assess the 25-OH vitamin D serum level in cirrhotic patients and it’s relation to spontaneous bacterial peritonitis. Patient & Methods The current study included 90 patients divided into three groups; group one; patients with compensated liver cirrhosis, group two; patients with decompensated liver cirrhosis without SBP and group three; patients who had decompensated cirrhosis with SBP. The following laboratory work up was done: Serum 25-OH vitamin D level, liver functions test, kidney functions test, complete blood count, and ascitic neutrophil count. Results We report a highly significant difference between the studied groups as regards 25-OH vitamin D level, being lowest in group three. A negative correlation between markers of severe cirrhosis and vitamin D concentrations was found in our cirrhotic patients. Conclusion Vitamin D deficiency is associated with increased incidence of infections in cirrhotic patients including spontaneous bacterial peritonitis, suggesting that Vitamin D supplementation may be useful in these patients.

scholarly journals Assessment of serum 25-hydroxy vitamin D in cirrhotic patients with and without spontaneous bacterial peritonitis (SBP)

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
S M Shalaby ◽  
E M Baiumy ◽  
M G Abdelrahman ◽  
M M Sayed ◽  
R M Abdelhalim ◽  
...  
Keyword(s):  
Vitamin D ◽  
Liver Cirrhosis ◽  
Bacterial Infections ◽  
Spontaneous Bacterial Peritonitis ◽  
Complete Blood Count ◽  
Decompensated Cirrhosis ◽  
Bacterial Peritonitis ◽  
Significant Difference ◽  
Cirrhotic Patients ◽  
25 Oh Vitamin D

Abstract Background Vitamin D has pleotropic effect including the immune function, it increases innate immunity and modifies lymphocyte activation. The risk for bacterial infections is increased in cirrhotic patients due to low levels of vitamin D, so its deficiency may be linked with the prevalence of SBP in cirrhotic patients Aim of the work To assess the 25-OH vitamin D serum level in cirrhotic patients and it’s relation to spontaneous bacterial peritonitis. Patient & Methods The current study included 90 patients divided into three groups; group one; patients with compensated liver cirrhosis, group two; patients with decompensated liver cirrhosis without SBP and group three; patients who had decompensated cirrhosis with SBP. The following laboratory work up was done: Serum 25-OH vitamin D level, liver functions test, kidney functions test, complete blood count, and ascitic neutrophil count. Results We report a highly significant difference between the studied groups as regards 25-OH vitamin D level, being lowest in group three. A negative correlation between markers of severe cirrhosis and vitamin D concentrations was found in our cirrhotic patients. Conclusion Vitamin D deficiency is associated with increased incidence of infections in cirrhotic patients including spontaneous bacterial peritonitis, suggesting that Vitamin D supplementation may be useful in these patients.

scholarly journals Spontaneous Bacterial Peritonitis Caused byHafnia alveiin a Patient with Liver Cirrhosis

2010 ◽  
Vol 42 (6) ◽  
pp. 420 ◽  
Author(s):  
Sang Kyung Jung ◽  
June Sung Lee ◽  
Kyung Ah Kim ◽  
Young Doo Kim ◽  
Yoon Jung Jwa ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Spontaneous Bacterial Peritonitis ◽  
Bacterial Peritonitis

scholarly journals Renal impairment after Spontaneous Bacterial Peritonitis (SBP) in cirrhotic population.

2019 ◽  
Vol 26 (12) ◽  
pp. 2235-2240
Author(s):  
Asif Javaid Wakani ◽  
Riaz Hussain Awan ◽  
Seema Nayab ◽  
Khadim Hussain Awan ◽  
Faqir Muhammad Awan
Keyword(s):  
Liver Cirrhosis ◽  
Renal Impairment ◽  
Serum Creatinine ◽  
Spontaneous Bacterial Peritonitis ◽  
National Hospital ◽  
Cross Sectional ◽  
Bacterial Peritonitis ◽  
Serum Blood Urea Nitrogen ◽  
Patient’S Information ◽  
The Mean

Objectives: To evaluate the frequency of renal impairment after spontaneous bacterial peritonitis (SBP) in cirrhotic population. Study Design: The study was conducted as Descriptive Cross-Sectional. Setting: Liaquat National Hospital Karachi. Period: For six months (October 01, 2015 to March 31, 2016). Methodology: The subjects with liver cirrhosis spontaneous bacterial peritonitis (SBP) were evaluated for serum creatinine and serum blood urea nitrogen (BUN) for evaluation of renal impairment while the patient’s information was recorded on proforma and analyzed in SPSS-15.0. Results: The mean ±SD of age, BUN and serum creatinine for whole population was 50.69±10.69 years, 22.4197±11.64742 and 1.2207±0.92535. Renal impairment was detected in 40 (27.2%) individuals while it is normal in 107 (72.8%) subjects. Conclusion: The renal impairment after SBP in cirrhotic population is higher in present study.

Sign in / Sign up

Export Citation Format

Share Document