The role of urinary Retinol binding protein (RBP) as a novel biomarker in early detection of kidney affection in patients with psoriatic arthritis

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Dina Ahmed Abdel Moneim Ibrahim ◽  
Hala Abdul Hady Saleh ◽  
Nayera Zaghloul Saber
Keyword(s):  
Psoriatic Arthritis ◽  
Early Detection ◽  
Renal Involvement ◽  
Retinol Binding Protein ◽  
Laboratory Evaluation ◽  
Tubular Damage ◽  
Inflammatory Disorder ◽  
Renal Tubular Damage ◽  
Das 28 ◽  
Renal Tubular

Abstract Background PsA is a chronic multisystem inflammatory disorder with various systemic diseases. Renal involvement in patients with PsA is sparsely studied and its association is still unclear. This entity is called “Psoriatic Nephropathy”. RBP has been proposed as the most sensitive marker for detection of renal tubule function loss. Aim We aim at early detection of renal tubular damage by measuring the level of urinary RBP as a novel biomarker in patients with psoriatic arthritis in relation to activity and severity. Methods We conducted a Cross-sectional study of 30 PsA patients from Physical Medicine, Rheumatology and Rehabilitation and Dermatology outpatients’ clinics at Ain Shams University Hospitals. They were subjected to full medical history taking and thorough clinical examination with calculation of DAS 28, PASI and HAQ scores. Full Laboratory evaluation included CBC, ESR, CRP, serum creatinine, BUN, SGOT, SGPT, urine analysis, estimated GFR (eGFR) and urinary RBP were measured for all the participants. The urinary RBP and eGFR were compared with 30 age and sex matched healthy controls. Results The urinary RBP mean±SD (ng/ml) was found to be 351.667±119.397 in patients and was statistically significantly higher in them than in controls 93.16±30.836 (t = 11.482, p < 0.001) and it was statistically significantly correlated with disease duration, disease activity according to DAS 28 and the severity of skin affection according to PASI score. While eGFR (ml/min) was found to be 131.729±28.943 in patients and it was statistically significantly lower in them than in controls 146.708±16.607 (t=-2.459, p = 0.017), however there was no statistically significant correlations with either DAS 28 or PASI scores. Conclusion Urinary RBP has been described as a novel biomarker in early detection of kidney affection and renal tubular damage in psoriatic arthritis patients.

Assessment of urinary retinol-binding protein as an index of proximal tubular injury.

1987 ◽  
Vol 33 (6) ◽  
pp. 775-779 ◽  
Author(s):  
A M Bernard ◽  
A A Vyskocil ◽  
P Mahieu ◽  
R R Lauwerys
Keyword(s):  
Urinary Excretion ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Tubular Damage ◽  
Tubular Injury ◽  
Renal Tubular Damage ◽  
Acid Urine ◽  
Beta 2 ◽  
Renal Tubular ◽  
Beta 2 Microglobulin

Abstract The urinary excretion of retinol-binding protein (RBP), beta 2-microglobulin (beta 2-m), and beta-N-acetyl-D-glucosaminidase was monitored in patients with renal tubular damage secondary to multiple injuries, rhabdomyolysis, antibiotic treatment, or poisoning by various chemicals such as solvents, heavy metals, or pesticides. In almost all cases, RBP proved to be a more sensitive index of renal tubular damage than was beta-N-acetyl-D-glucosaminidase and, being more stable in acid urine, a more practical analyte to measure than was beta 2-m. We corroborated this finding by studying the relationships between these three analytes in more than 150 patients. On the average, an increase in the urinary excretion of beta-N-acetyl-D-glucosaminidase becomes detectable when urinary RBP already exceeds the normal value by 50- to 100-fold. In urines with pH greater than 6, RBP and beta 2-m concentrations are well correlated (r = 0.93, n = 150), beta 2-m tending to be more frequently positive (i.e., greater than 311 micrograms/L). But in urines with pH less than 6 (about 30-40% of the samples), the RBP/beta 2-m concentration ratio increases as pH decreases, up to 500 in some patients with massive tubular injury. Because the renal uptake of proteins involves a saturable process, the urinary excretion of RBP, like that of beta 2-m, specifically reflects the reabsorption capacity of proximal tubules only when the glomerular filtration rate is normal or slightly impaired (i.e., serum creatinine less than 20 mg/L). Under these conditions the determination of RBP protein in urine appears the most appropriate test when early detection of tubular injury is desirable.

Fractional excretion of magnesium as an early indicator of renal tubular damage in normotensive diabetic nephropathy

2020 ◽  
Vol 45 (5) ◽  
pp. 543-551
Author(s):  
Fatih Ozcelik ◽  
Serif Kactas ◽  
Halime Hanim Pence ◽  
Saadet Kurcenli ◽  
Erdim Sertoglu ◽  
...  
Keyword(s):  
Fractional Excretion ◽  
Study Patient ◽  
Control Group ◽  
Tubular Damage ◽  
Renal Tubular Damage ◽  
Renal Tubular ◽  
Excretion Rates ◽  
Urine And Serum ◽  
Diagnostic And Prognostic Value

AbstractObjectivesThe aim of the present study is to evaluate the diagnostic powers of fractional magnesium, sodium and potassium as markers of renal tubular damage in normotensive type 2 diabetes mellitus (T2DM) patients with respect to microalbuminuria and estimated glomerular filtration rate (eGFR).Materials and methodsForty healthy volunteers and 91 normotensive T2DM patients were included in the study. Patient group was divided into two according to albuminuria level; 49 were normoalbuminuric and 42 were microalbuminuric. In addition to albumin in urine, urine and serum Na, K, Mg and creatinine values were measured to calculate fractional electrolyte excretion rates.ResultsIn normoalbuminuric and microalbuminuric groups, fractional excretion of magnesium (FEMg) values were found to be significantly higher than the control group (p < 0.05). There was a moderate correlation between FEMg and albümin to cratinin ratio (ACR) (Spearman r = 0.3215, p < 0.05). In the ROC analysis for eGFR and FEMg based on microalbuminuria, the areas under the curve were 0.625 and 0.732, respectively (diagnostic sensitivity 59.52% and 66.67%; specificity 70.79% and 77.53%, p < 0.05).ConclusionFor renal tubular damage predicted by microalbuminuria, FEMg could be accepted as a candidate biochemical marker with diagnostic and prognostic value.

Tactical approaxhes to diagnosis and treatment of hepatorenal syndrome in patients with blastomatous obstructive jaundice

2021 ◽  
Vol 42 (2) ◽  
pp. 28-31
Author(s):  
S. V. Kosulin ◽  
◽  
Ju. O. Vinnik ◽  
Ju. V. Ivanova ◽  
◽  
...  
Keyword(s):  
Obstructive Jaundice ◽  
Hepatorenal Syndrome ◽  
Resistance Index ◽  
Doppler Imaging ◽  
Coagulation System ◽  
Tubular Damage ◽  
Renal Tubular Damage ◽  
Renal Tubular ◽  
Neutrophil Gelatinase

The article discusses problems of early diagnosis and, accordingly, treatment of hepatorenal syndrome (HRS) in case of obstructive jaundice of blastomatous origin. The results of a comprehensive examination of 37 patients with blastomatous obstructive jaundice (OJ) with clinical and laboratory signs of HRS were analyzed. Patients were evaluated for clinical and biochemical parameters of blood and urine, blood electrolytes, indicators of the blood coagulation system according to unified methods. The main work is devoted to the determination of the biomarker of renal tubular damage, neutrophil-gelatinase-associated lipocaine (s-NGAL) as a marker and indicator of HRS severity, careful and detailed analysis, monitoring of levels (s-NGAL) and other bioactive substances as an indicator of treatment efficacy. Introduction of active ultrasound as a replacement for contrast computer tomography to reduce the load on precompromised kidneys. It has been proven that the level of renal tubular damage, neutrophil-gelatinase-associated lipocaine s-NGAL is an early marker of renal damage whose function is to reduce the severity of damage to the proximal tubules of the kidneys, normalize damaged tissue by participating in apoptosis, increase survival of damaged restoration of damaged epithelium, stimulation of differentiation and structural reorganization of renal epithelial cells. The fact that s-NGAL was not significantly reduced in the stage of recovery of diuresis, confirms the presence of patients with blastomatous MF severe and persistent toxic tubulointerstitial disorders. Based on this determination of the biomarker (s-NGAL) in the serum of patients with blastomatous mechanical jaundice and performing in them at primary ultrasound color Doppler mapping and pulsed wave Doppler imaging of the kidneys with the calculation of the resistance index may serve as early signs of damage.

Chronic Renal Tubular Damage Caused by Cyclosporin A

1989 ◽  
pp. 309-314
Author(s):  
P. H. Whiting ◽  
N. J. Saunders ◽  
K. J. Thomson ◽  
J. G. Simpson
Keyword(s):  
Cyclosporin A ◽  
Tubular Damage ◽  
Renal Tubular Damage ◽  
Renal Tubular

Silencing of SOCS‐1 and SOCS‐3 suppresses renal interstitial fibrosis by alleviating renal tubular damage in a rat model of hydronephrosis

2017 ◽  
Vol 119 (2) ◽  
pp. 2200-2211 ◽  
Author(s):  
Gui‐Hong Zheng ◽  
Yong‐Jian Wang ◽  
Xin Wen ◽  
Xin‐Rui Han ◽  
Min Shen ◽  
...  
Keyword(s):  
Rat Model ◽  
Interstitial Fibrosis ◽  
Tubular Damage ◽  
Renal Interstitial Fibrosis ◽  
Renal Tubular Damage ◽  
Renal Tubular

scholarly journals Soluble receptor for advanced glycation end products protects from ischemia- and reperfusion-induced acute kidney injury

Biology Open ◽  
2021 ◽  
Author(s):  
Taro Miyagawa ◽  
Yasunori Iwata ◽  
Megumi Oshima ◽  
Hisayuki Ogura ◽  
Koichi Sato ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Advanced Glycation End Products ◽  
Ischemia Reperfusion ◽  
Kidney Injury ◽  
Tubular Damage ◽  
Advanced Glycation ◽  
Renal Tubular Damage ◽  
Glycation End Products ◽  
End Products ◽  
Renal Tubular

The full-length receptor for advanced glycation end products (RAGE) is a multiligand pattern recognition receptor. High-mobility group box 1 (HMGB1) is a RAGE ligand of damage-associated molecular patterns that elicits inflammatory reactions. The shedded isoform of RAGE and endogenous secretory RAGE (esRAGE), a splice variant, are soluble isoforms (sRAGE) that act as organ-protective decoys. However, the pathophysiologic roles of RAGE/sRAGE in acute kidney injury (AKI) remain unclear. We found that AKI was more severe, with enhanced renal tubular damage, macrophage infiltration, and fibrosis, in mice lacking both RAGE and sRAGE than in wild-type control mice. Using murine tubular epithelial cells (TECs), we demonstrated that hypoxia upregulated messenger RNA (mRNA) expression of HMGB1 and tumor necrosis factor α (TNF-α), whereas RAGE and esRAGE expressions were paradoxically decreased. Moreover, the addition of recombinant sRAGE canceled hypoxia-induced inflammation and promoted cell viability in cultured TECs. sRAGE administration prevented renal tubular damage in models of ischemia/reperfusion-induced AKI and of anti-glomerular basement membrane (anti-GBM) glomerulonephritis. These results suggest that sRAGE is a novel therapeutic option for AKI.

Renal Tubular Damage After Renal Stone Treatment

1989 ◽  
Vol 141 (2) ◽  
pp. 465-465
Author(s):  
A. Trinchieri ◽  
A. Mandressi ◽  
G. Zanetti ◽  
M. Ruoppolo ◽  
P. Tombolini ◽  
...  
Keyword(s):  
Renal Stone ◽  
Tubular Damage ◽  
Renal Tubular Damage ◽  
Stone Treatment ◽  
Renal Tubular
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