scholarly journals P68 Age-related muscle strength decline in mid-late life varies in men and women and is associated with diet and physical activity: observations from the Hertfordshire Cohort Study

Rheumatology ◽  
2020 ◽  
Vol 59 (Supplement_2) ◽  
Author(s):  
Jean Zhang ◽  
Faidra Laskou ◽  
Karen Jameson ◽  
Cyrus Cooper ◽  
Elaine M Dennison
Keyword(s):  
Physical Activity ◽  
Cohort Study ◽  
Muscle Strength ◽  
Grip Strength ◽  
Functional Limitation ◽  
Community Dwelling ◽  
P Value ◽  
Age Related ◽  
Diet And Physical Activity ◽  
Hertfordshire Cohort Study

Abstract Background In the context of an aging population, age-related decline in muscle strength is well recognised, and is associated with functional limitation and increased mortality. However, scarce epidemiological data are available regarding its prevalence, or lifestyle associations at a time when intervention is still possible to retard or prevent loss. We considered these issues in the Hertfordshire Cohort Study, a cohort of late-middle aged community dwelling adults. Methods 2,987 participants were seen in 1999-2004, 1,572 men and 1,415 women. A lifestyle questionnaire was administered that asked about social class, physical activity, diet, co-morbidities and cigarette and alcohol consumption. Grip strength was measured with a Jamar dynamometer, three times on each side with the highest value used. Age related muscle strength decline was defined, according to current convention, as a grip strength <30kg in men and <20 kg in women. Results The mean age of participants was 65.8 (IQR 63.5-67.8) years for men and 66.5 (IQR 64.5-68.7) years for women. Muscle strength decline was more common in women (10.3%) than men (3%); the odds ratio (OR) for age-related muscle strength decline was 3.73 (95%CI 2.66-5.23) in women relative to men (p < 0.001). Factors that appeared protective included higher physical activity scores in men (OR 0.97, 95%CI 0.96-0.99, p = 0.003) and in women (OR 0.97, 95%CI 0.96-0.98, p < 0.001) and a higher prudent diet score in women (OR: 0.74, 95%CI 0.60-0.90 p = 0.003). Muscle strength decline was strongly associated with quality of life in women (p ≤ 0.001) as assessed by SF36 and EuroQoL EQ-5D for all domains, although EuroQOL anxiety/depression and SF36 role emotional were less strongly associated (p-value=0.042, p-value=0.006, respectively). Table 1 shows self-reported impaired ability to move, self-care, perform usual activities and increased pain were associated with higher risk of age-related muscle strength decline in women. Conclusion Age related muscle strength decline was more common in community dwelling women than men, and diet and physical activity were predictors of such decline. Research into effective preventative interventions is now warranted. Disclosures J. Zhang None. F. Laskou None. K. Jameson None. C. Cooper None. E.M. Dennison None.

scholarly journals What influences diet quality in older people? A qualitative study among community-dwelling older adults from the Hertfordshire Cohort Study, UK

2017 ◽  
Vol 20 (15) ◽  
pp. 2685-2693 ◽  
Author(s):  
Ilse Bloom ◽  
Wendy Lawrence ◽  
Mary Barker ◽  
Janis Baird ◽  
Elaine Dennison ◽  
...  
Keyword(s):  
Older Adults ◽  
Cohort Study ◽  
Older People ◽  
Social Engagement ◽  
Community Dwelling ◽  
Related Factors ◽  
Age Related ◽  
Hertfordshire Cohort Study ◽  
The Uk ◽  
Community Dwelling Older Adults

AbstractObjectiveTo explore influences on diet in a group of community-dwelling older adults in the UK.DesignData were collected through focus group discussions with older people; discussions were audio-recorded, transcribed verbatim and transcripts analysed thematically.SettingHertfordshire, UK.SubjectsParticipants were sampled purposively from the Hertfordshire Cohort Study, focusing on those whose diets had been assessed at two time points: 1998–2001 and 2011.ResultsNinety-two adults participated (47 % women; 74–83 years) and eleven focus groups were held. A number of age-related factors were identified that were linked to food choices, including lifelong food experiences, retirement, bereavement and medical conditions, as well as environmental factors (such as transport). There appeared to be variability in how individuals responded to these influences, indicating that other underlying factors may mediate the effects of age-related factors on diet. Discussions about ‘keeping going’, being motivated to ‘not give up’, not wanting to be perceived as ‘old’, as well as examples of resilience and coping strategies, suggest the importance of mediating psychological factors. In addition, discussion about social activities and isolation, community spirit and loneliness, indicated the importance of social engagement as an influence on diet.ConclusionsInterventions to promote healthier diets in older age should take account of underlying psychological and social factors that influence diet, which may mediate the effects of age-related factors.

scholarly journals ACE inhibitors, statins and thiazides: no association with change in grip strength among community dwelling older men and women from the Hertfordshire Cohort Study

2014 ◽  
Vol 43 (5) ◽  
pp. 661-666 ◽  
Author(s):  
Miles D. Witham ◽  
Holly E. Syddall ◽  
Elaine Dennison ◽  
Cyrus Cooper ◽  
Marion E. T. McMurdo ◽  
...  
Keyword(s):  
Cohort Study ◽  
Grip Strength ◽  
Ace Inhibitors ◽  
Older Men ◽  
Community Dwelling ◽  
Men And Women ◽  
Hertfordshire Cohort Study ◽  
Older Men And Women

scholarly journals Association of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) with Muscle Strength in Community-Dwelling Elderly with Knee Osteoarthritis

2020 ◽  
Vol 17 (7) ◽  
pp. 2260 ◽  
Author(s):  
Mi-Ji Kim ◽  
Byeong-Hun Kang ◽  
Soo-Hyun Park ◽  
Bokyoung Kim ◽  
Gyeong-Ye Lee ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Knee Osteoarthritis ◽  
Grip Strength ◽  
Functional Limitation ◽  
Peak Torque ◽  
Knee Extension ◽  
Community Dwelling ◽  
Nutrition Status ◽  
Womac Pain ◽  
Womac Function

Purpose: The purpose of this study was to evaluate the correlation between muscle strength and knee symptoms (pain, stiffness, and functional limitation) regardless of the presence of radiologic knee osteoarthritis (RKOA) in community-dwelling elderly. Patients and methods: This cross-sectional study used data from the Namgaram-2 cohort. The Namgaram-2 cohort consisted of participants living in three rural communities. Such participants were included for studies on activity limitation due to age-related musculoskeletal disorders including knee osteoarthritis, osteoporosis, and sarcopenia. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), a health assessment tool for patients with arthritis in lower extremities, was used to assess health-related quality of life (HRQOL). Muscle strengths were measured by knee strength (by using the isokinetic dynamometer) and hand grip strength. Results: The WOMAC pain of Kallgren–Lawrence (K/L) grade < 2 was correlated with age, grip strength, nutrition status, and knee extension 180 peak torque. The WOMAC pain of K/L grade ≥ 2 was correlated with age, nutrition status, and knee extension 60 peak torque. The WOMAC stiffness of K/L grade < 2 was correlated with having a spouse, nutrition status, and knee extension 60 peak torque. The WOMAC stiffness of K/L grade ≥ 2 was correlated with knee extension 60 peak torque. The WOMAC function of K/L grade < 2 was correlated with age, grip strength, osteoporosis, nutrition status, and knee extension 180 peak torque. The WOMAC function of K/L grade ≥ 2 was correlated with age, nutrition status, and knee extension 60 peak torque. Conclusion: Muscle strength as measured by grip strength and knee extension was statistically significantly correlated with the WOMAC scores in patients with knee symptoms regardless of whether radiologic signs of knee osteoarthritis were observed.

scholarly journals Diet and Its Relationship with Grip Strength in Community-Dwelling Older Men and Women: The Hertfordshire Cohort Study

2008 ◽  
Vol 56 (1) ◽  
pp. 84-90 ◽  
Author(s):  
Sian M. Robinson ◽  
Karen A. Jameson ◽  
Sue F. Batelaan ◽  
Helen J. Martin ◽  
Holly E. Syddall ◽  
...  
Keyword(s):  
Cohort Study ◽  
Grip Strength ◽  
Older Men ◽  
Community Dwelling ◽  
Men And Women ◽  
Hertfordshire Cohort Study ◽  
Older Men And Women

scholarly journals O05 How does radiographic knee OA impact musculoskeletal aging in midlife? Findings from the Hertfordshire Cohort study

Rheumatology ◽  
2020 ◽  
Vol 59 (Supplement_2) ◽  
Author(s):  
Nicholas R Fuggle ◽  
Michael Clynes ◽  
Faidra Laskou ◽  
Karen Jameson ◽  
Cyrus Cooper ◽  
...  
Keyword(s):  
Physical Activity ◽  
Knee Osteoarthritis ◽  
Grip Strength ◽  
Community Dwelling ◽  
Hand Osteoarthritis ◽  
Mineral Density ◽  
Knee Oa ◽  
Hertfordshire Cohort Study ◽  
Community Dwelling Older Adults

Abstract Background With an aging population, the burden of musculoskeletal aging in joints, bones and muscles carries with it significant morbidity. Osteoarthritis (OA) is the most common joint condition, and can be defined clinically or radiologically. Musculoskeletal aging in bone and muscle can be assessed through change in body composition, grip strength and physical performance. The aim of this study was to investigate whether a diagnosis of radiological knee OA impacted involution in muscle or bone in the midlife in a group of community-dwelling older adults in the UK. Methods Our study comprised 220 members of the Hertfordshire Cohort Study (118 males and 102 females), a group of community dwelling older adults in the United Kingdom. Knee radiographs were performed at baseline (1999-2003), with osteoarthritis defined as a Kellgren and Lawrence score ≥2. At baseline and follow-up (2017) questionnaires assessed physical activity and lifestyle factors; JAMAR dynamometry was performed to assess grip strength; 8 foot walk test was performed to assess gait speed and DXA was performed to assess bone mineral density at the hips and body composition. Linear regression was performed to analyse associations in males and females, before and after adjustment for follow-up time, lifestyle factors (including smoking, alcohol consumption, social class, calcium intake and physical activity), anthropometric measures (BMI) and HRT use and age at menopause in women. The development of hand osteoarthritis was adjusted for grip strength outcomes. Results The mean age of participants at baseline was 65.0 years. Median follow-up was 16.7 years (range 15.0-18.4 years). Knee osteoarthritis was present in 75 (34%) participants. Radiographic knee osteoarthritis status at baseline was significantly associated with grip strength (β=-3.2kg, -5.3 to -1.1, p &lt; 0.01) at follow-up in females but not in males (β=-2.9, -5.8 to 0.1, p = 0.06). No significant associations between radiographic osteoarthritis status at baseline and other measures of sarcopenia (gait speed or lean mass) or bone mineral density were found in either sex. Conclusion Our findings demonstrate that the presence of knee osteoarthritis in midlife can have a substantial bearing on grip strength in women over 15 years later independent of the presence of hand osteoarthritis. Grip strength has been shown to correlate closely with lower limb strength and so the demonstrated association between grip strength and knee osteoarthritis is representative of a global weakness resulting from the disease. Reduction in grip strength has been associated with an increased risk of morbidity including falls and fractures. Thus, in order to countermand this association, it may be that concerted interventions (including physical therapy, strengthening and surgical intervention) should be recommended for those with knee osteoarthritis at this stage in the lifecourse. Of course, these findings require replication and validation in other cohorts. Disclosures N.R. Fuggle None. M. Clynes None. F. Laskou None. K. Jameson None. C. Cooper None. E. Dennison None.

scholarly journals Muscle Strength, Physical Activity, and Functional Limitations in Older Adults with Central Obesity

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Cassandra M. Germain ◽  
John A. Batsis ◽  
Elizabeth Vasquez ◽  
Douglas R. McQuoid
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Muscle Strength ◽  
Grip Strength ◽  
Functional Impairment ◽  
Central Obesity ◽  
Functional Limitations ◽  
Logistic Models ◽  
Community Dwelling ◽  
Increased Risk

Background.Obesity and muscle weakness are independently associated with increased risk of physical and functional impairment in older adults. It is unknown whether physical activity (PA) and muscle strength combined provide added protection against functional impairment. This study examines the association between muscle strength, PA, and functional outcomes in older adults with central obesity.Methods.Prevalence and odds of physical (PL), ADL, and IADL limitation were calculated for 6,388 community dwelling adults aged ≥ 60 with central obesity. Individuals were stratified by sex-specific hand grip tertiles and PA. Logistic models were adjusted for age, education, comorbidities, and body-mass index and weighted.Results.Overall prevalence of PL and ADL and IADL limitations were progressively lower by grip category. Within grip categories, prevalence was lower for individuals who were active than those who were inactive. Adjusted models showed significantly lower odds of PL OR 0.42 [0.31, 0.56]; ADL OR 0.60 [0.43, 0.84], and IADL OR 0.46[0.35, 0.61] for those in the highest grip strength category as compared to those in the lowest grip category.Conclusion.Improving grip strength in obese elders who are not able to engage in traditional exercise is important for reducing odds of physical and functional impairment.

scholarly journals P111 Osteoporosis is a significant predictor of frailty in older community dwelling adults: findings from the Hertfordshire Cohort Study

Rheumatology ◽  
2021 ◽  
Vol 60 (Supplement_1) ◽  
Author(s):  
Faidra Laskou ◽  
Karen Jameson ◽  
Elaine Dennison
Keyword(s):  
Cohort Study ◽  
Grip Strength ◽  
Predictive Factor ◽  
Community Dwelling ◽  
Mineral Density ◽  
Explanatory Variables ◽  
Asian Populations ◽  
Japanese Cohort ◽  
Hertfordshire Cohort Study ◽  
The Uk

Abstract Background/Aims  Frailty is associated with a range of adverse health outcomes, including falls and fractures. Previous work in a Japanese cohort found that the presence of both osteoporosis (OP) and sarcopenia (SP) increased the risk of frailty compared to the presence of OP or SP alone. We examined these relationships in a comparable cohort of community dwelling older people in the UK. Methods  Our study comprised of 432 participants (216 men and 216 women) of the UK the Hertfordshire Cohort Study (HCS). Participants were assessed at baseline and followed up 5 years later with questionnaires, clinical examination, measures of physical performance and grip strength. Proximal femur bone mineral density (BMD) values were determined using dual-energy X-ray absorptiometry. OP was defined at BMD T- scores &lt; = -2.5 at the femoral neck or use of anti-osteoporosis medication. Cut-offs for low grip strength; &lt;30kg for men and &lt;20kg for women and ALM index &lt; =7.23kg/m2 for men, &lt; =5.67kg/m2 for women, were used to define SP. Frailty was defined using the Fried definition. Logistic regressions were performed to analyse associations of OP/SP as explanatory variables for frailty. Results  The mean (SD) age of participants was 75.7 (2.6) years. At baseline, the prevalence of frailty and pre-frailty was 12.2% (men, 8%, women, 16.3 %), and 57% (men, 55.7%; women, 58.2%) respectively. Individuals living with frailty were older, tended to drink less alcohol, have lower physical activity, lower walking speed and grip strength (P &lt; 0.001). They were more likely to be female compared to non-frail subjects (P = 0.007). Co-existence of SP, OP and frailty was observed in 0.6% of the population; 0.6% had SP and frailty; 1.6% had OP and frailty and 1.6% of the study population had SP and OP. 71.8% did not have SP, OP or frailty at baseline. SP was significantly associated with frailty at baseline (p &lt; 0.001). The cumulative incidence of frailty during the 5-year period was 2.47% /year (2.13%/year in men, 2.89%/year in women) and that of SP was 2.14%/year (2.84% in men, 1.35%/year in women). The presence of OP at baseline was a significant predictive factor for the occurrence of frailty at follow-up (odds ratio [OR], 3.04; 95% confidence interval [95% CI], 1.11,8.38; P = 0.031), while the risk of developing frailty was also increased in those participants who were both osteoporotic and sarcopenic at baseline; though this was not significant (OR; 10.08, 95% CI,0.55,186.08; P = 0.12). Conclusion  Our findings demonstrate that the presence of OP is a significant predictive factor for developing frailty and might be used as a trigger for appropriate interventions to reduce or reverse its development in older adults. Our findings are in accordance with the previous reports in Asian populations and warrant further investigation in other national cohorts. Disclosure  F. Laskou: None. K. Jameson: None. E. Dennison: None.

scholarly journals Relationship Between Physical Activity and Function With Quality of Life in Community-Living Older Adults

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 189-189
Author(s):  
Milan Chang ◽  
Olof Geirsdottir ◽  
Inga Thorsdottir ◽  
Palmi Jonsson ◽  
Alfons Ramel ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Older Adults ◽  
Muscle Strength ◽  
Physical Function ◽  
Grip Strength ◽  
Community Dwelling ◽  
Walking Distance ◽  
Community Dwelling Older Adults

Abstract Background: Quality of life (QOL) is a multidimensional concept which is often used as an evaluation of a person‘s health and psychological status. Increasing longevity can be associated with better QOL as long as older adults are independent in daily life. The aim of the study was to examine the associations of QOL with muscle strength and physical function among community-dwelling older adults. Methods: The current cross-sectional study had 225 participants (73.7±5.7yrs, 58.2% female) living in Reykjavik, Iceland. QOL measured using the 36-item short-form survey (SF-36). Covariates were anthropometrics, muscle strength, physical function including timed up and go test (TUG), and 6-minute walking distance (6MWD), physical activity per week (PA). Linear regression analysis was used to examine the association of QOL with physical function. Results: The mean QOL score for the study population was 54.9±6.13. The analysis was adjusted for age and gender, body mass index, height, and PA. We found that QOL was associated with better grip strength (B=1.4, P&lt;0.0001), 6MWD (B=0.03, P&lt;0.0001), slower TUG (B=-0.9, P&lt;0.0001), and higher PA (B=0.03 m, P=0.039). However, QOL was not associated with quadriceps leg strength. Conclusion: The study suggests that QOL was associated with better physical function including grip strength, walking ability and the level of PA among community-dwelling older adults in Iceland.

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