scholarly journals Sex and gender differences in axial spondyloarthritis: myths and truths

Rheumatology ◽  
2020 ◽  
Vol 59 (Supplement_4) ◽  
pp. iv38-iv46
Author(s):  
Tamara Rusman ◽  
Rianne E van Bentum ◽  
Irene E van der Horst-Bruinsma
Keyword(s):  
Gender Differences ◽  
Sex Differences ◽  
Recent Literature ◽  
Axial Spondyloarthritis ◽  
Clinical Aspects ◽  
Sex And Gender ◽  
Disease Manifestation ◽  
Drug Effectiveness ◽  
And Gender ◽  
Sex And Gender Differences

Abstract Mounting evidence reveals evident sex differences in physiology, disease presentation and response to medication in axial SpA (axSpA). Unfortunately these data are often neglected in clinical practice and research. In this review, myths that still exist on diagnosis, disease manifestation and drug effectiveness were argued against data of the most recent literature. The aim is to increase awareness of sex differences in the clinical aspects of axSpA.

scholarly journals Sex and Gender Differences Research Design for Basic, Clinical, and Population Studies: Essentials for Investigators

2018 ◽  
Vol 39 (4) ◽  
pp. 424-439 ◽  
Author(s):  
Janet W Rich-Edwards ◽  
Ursula B Kaiser ◽  
Grace L Chen ◽  
JoAnn E Manson ◽  
Jill M Goldstein
Keyword(s):  
Gender Differences ◽  
Sex Differences ◽  
Population Studies ◽  
Effect Modification ◽  
Sex And Gender ◽  
Subject Selection ◽  
Funding Agencies ◽  
Males And Females ◽  
And Gender ◽  
Sex And Gender Differences

Abstract A sex- and gender-informed perspective increases rigor, promotes discovery, and expands the relevance of biomedical research. In the current era of accountability to present data for males and females, thoughtful and deliberate methodology can improve study design and inference in sex and gender differences research. We address issues of motivation, subject selection, sample size, data collection, analysis, and interpretation, considering implications for basic, clinical, and population research. In particular, we focus on methods to test sex/gender differences as effect modification or interaction, and discuss why some inferences from sex-stratified data should be viewed with caution. Without careful methodology, the pursuit of sex difference research, despite a mandate from funding agencies, will result in a literature of contradiction. However, given the historic lack of attention to sex differences, the absence of evidence for sex differences is not necessarily evidence of the absence of sex differences. Thoughtfully conceived and conducted sex and gender differences research is needed to drive scientific and therapeutic discovery for all sexes and genders.

scholarly journals Stroke in Women

Stroke ◽  
2021 ◽  
Vol 52 (2) ◽  
pp. 726-728
Author(s):  
Moira K. Kapral ◽  
Cheryl Bushnell
Keyword(s):  
Gender Differences ◽  
Sex Differences ◽  
Endovascular Therapy ◽  
Sex And Gender ◽  
Hypertensive Disorders Of Pregnancy ◽  
Therapy Outcomes ◽  
Hypertensive Disorders ◽  
History Of ◽  
And Gender ◽  
Sex And Gender Differences

Sex differences exist in the epidemiology, care, and outcomes of stroke. This article highlights recent advances in our understanding of sex and gender differences in the benefits of endovascular therapy, outcomes after stroke and transient neurological events, and the potential to prevent stroke in women with a history of hypertensive disorders of pregnancy.

scholarly journals MetaFun: Unveiling sex differences in multiple omics studies through comprehensive functional meta-analysis

2021 ◽  
Author(s):  
Pablo Malmierca-Merlo ◽  
Ruben Sanchez-Garcia ◽  
Ruben Grillo-Risco ◽  
Irene Perez-Diez ◽  
José Francisco Català-Senent ◽  
...  
Keyword(s):  
Gender Differences ◽  
Sex Differences ◽  
Statistical Power ◽  
Meta Analysis ◽  
Sex And Gender ◽  
And Gender ◽  
Sex And Gender Differences

Sex and gender differences in different health scenarios has been thoroughly acknowledged in the literature, and yet, very scarcely analyzed. To fill the gap, here we present MetaFun, which allows to meta-analyze multiple omics datasets with a sex-based perspective, and to combine different datasets to gain major statistical power and to assist the researcher in understanding these sex differences in the diseases under study. Metafun is freely available at bioinfo.cipf.es/metafun

Sex and Gender Differences

2012 ◽  
Vol 220 (2) ◽  
pp. 57-60 ◽  
Author(s):  
Markus Hausmann ◽  
Barbara Schober
Keyword(s):  
Gender Differences ◽  
Sex And Gender ◽  
And Gender ◽  
Sex And Gender Differences

scholarly journals Influence of sex and gender on the management of late-stage knee osteoarthritis

2021 ◽  
Author(s):  
B. Moretti ◽  
A. Spinarelli ◽  
G. Varrassi ◽  
L. Massari ◽  
A. Gigante ◽  
...  
Keyword(s):  
Gender Differences ◽  
Knee Osteoarthritis ◽  
Healthcare Professionals ◽  
Pain Tolerance ◽  
Exact Nature ◽  
Sex And Gender ◽  
Physician Practices ◽  
Knee Oa ◽  
And Gender ◽  
Sex And Gender Differences

Abstract Purpose The exact nature of sex and gender differences in knee osteoarthritis (OA) among patient candidates for total knee arthroplasty (TKA) remains unclear and requires better elucidation to guide clinical practice. The purpose of this investigation was to survey physician practices and perceptions about the influence of sex and gender on knee OA presentation, care, and outcomes after TKA. Methods The survey questions were elaborated by a multidisciplinary scientific board composed of 1 pain specialist, 4 orthopedic specialists, 2 physiatrists, and 1 expert in gender medicine. The survey included 5 demographic questions and 20 topic questions. Eligible physician respondents were those who treat patients during all phases of care (pain specialists, orthopedic specialists, and physiatrists). All survey responses were anonymized and handled via remote dispersed geographic participation. Results Fifty-six physicians (71% male) accepted the invitation to complete the survey. In general, healthcare professionals expressed that women presented worse symptomology, higher pain intensity, and lower pain tolerance and necessitated a different pharmacological approach compared to men. Pain and orthopedic specialists were more likely to indicate sex and gender differences in knee OA than physiatrists. Physicians expressed that the absence of sex and gender-specific instruments and indications is an important limitation on available studies. Conclusions Healthcare professionals perceive multiple sex and gender-related differences in patients with knee OA, especially in the pre- and perioperative phases of TKA. Sex and gender bias sensitivity training for physicians can potentially improve the objectivity of care for knee OA among TKA candidates.

Rethinking an Assessment of Nicotine Dependence: A Sex, Gender and Diversity Analysis of the Fagerstrom Test for Nicotine Dependence

2007 ◽  
Vol 2 (2) ◽  
pp. 59-67 ◽  
Author(s):  
Lindsay Richardson ◽  
Lorraine Greaves ◽  
Natasha Jategaonkar ◽  
Kirsten Bell ◽  
Ann Pederson ◽  
...  
Keyword(s):  
Gender Differences ◽  
Nicotine Dependence ◽  
Diversity Analysis ◽  
Sex And Gender ◽  
Accurate Picture ◽  
And Gender ◽  
Diverse Groups ◽  
Sex And Gender Differences

AbstractThis article assesses whether the Fagerstrom Test for Nicotine Dependence (FTND), adequately reflects sex, gender and diversity related differences in nicotine dependence. Available studies on the FTND were reviewed and a sex, gender and diversity analysis (SGBA) of this instrument was conducted. Results indicate that sex and gender differences in nicotine dependence may undermine the ability of the FTND to present an adequate picture of dependence. Conducting a SGBA on this Fagerstrom test reveals that sex and gender differences likely limit the ability of this instrument to present an accurate picture of dependence in diverse groups. Further research is needed to enhance the sensitivity of the FTND.

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