scholarly journals Digital iontophoresis of vasoactive substances as measured by laser Doppler imaging—a non-invasive technique by which to measure microvascular dysfunction in Raynaud's phenomenon

Rheumatology ◽  
2004 ◽  
Vol 43 (8) ◽  
pp. 986-991 ◽  
Author(s):  
M. E. Anderson ◽  
T. L. Moore ◽  
M. Lunt ◽  
A. L. Herrick
Keyword(s):  
Raynaud’S Phenomenon ◽  
Microvascular Dysfunction ◽  
Raynaud's Phenomenon ◽  
Laser Doppler ◽  
Doppler Imaging ◽  
Invasive Technique ◽  
Laser Doppler Imaging ◽  
Non Invasive ◽  
Vasoactive Substances

Laser Doppler Imaging of Finger Skin Blood Flow in Patients after Microvascular Repair of the Ulnar Artery at the Wrist

1994 ◽  
Vol 19 (3) ◽  
pp. 295-300 ◽  
Author(s):  
S. BORNMYR ◽  
M. ARNER ◽  
H. SVENSSON
Keyword(s):  
Blood Flow ◽  
Skin Blood Flow ◽  
Ulnar Artery ◽  
Laser Doppler ◽  
Doppler Imaging ◽  
Invasive Technique ◽  
Microvascular Reconstruction ◽  
Laser Doppler Imaging ◽  
Non Invasive ◽  
Finger Tip

Laser Doppler imaging is a new, non-invasive technique allowing the spatial distribution and the temporal variation of the skin blood flow to be monitored. A mean blood flow value over an area, such as the finger-tip in the present study, can also be calculated. Recordings from 12 patients with a sutured ulnar artery following trauma did not significantly differ from those obtained in 14 controls. Four patients with a ligated ulnar artery, however, showed a slower restitution of blood flow values after cold provocation. All sutured ulnar arteries were found to be patent, which confirms that microvascular reconstruction of an injury to the ulnar artery at the wrist is worthwhile.

Comparison of thermography and laser Doppler imaging in the assessment of Raynaud’s phenomenon

2003 ◽  
Vol 66 (1) ◽  
pp. 73-76 ◽  
Author(s):  
Stuart Clark ◽  
Graham Dunn ◽  
Tonia Moore ◽  
Malcolm Jayson ◽  
Terence A King ◽  
...  
Keyword(s):  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Laser Doppler ◽  
Doppler Imaging ◽  
Laser Doppler Imaging

scholarly journals Clinical relevance of combining Thermography with Nailfold Capillaroscopy to improve differentiation between primary and secondary Raynaud’s Phenomenon

2021 ◽  
pp. 39-48
Author(s):  
Yumiko Vreeburg ◽  
Laura van Vugt ◽  
Sabrina Simonnet ◽  
Daphne Valk ◽  
Gus Schardijn ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Vascular Function ◽  
Raynaud’S Phenomenon ◽  
Challenge Test ◽  
Raynaud's Phenomenon ◽  
Nailfold Capillaroscopy ◽  
Invasive Technique ◽  
Microvascular Damage ◽  
Non Invasive ◽  
Age Related

Objectives: Early microvascular damage and dysfunction are clinically mirrored in Raynaud’s phenomenon (RP). Currently, nailfold capillaroscopy (NC) is applied to differentiate between primary RP (PRP) and secondary RP (PRP), associated with connective tissue disease. However, abnormal morphology can also be caused due to age-related changes and cardiovascular disease. Thermography (TG) is a non-invasive technique which enables quantification of cutaneous vascular function. An approach using both NC and TG could improve the differentiation between PRP and SRP. Methods: Thirty RP patients (PRP, n = 21; SRP, n = 9) underwent nailfold capillaroscopy and thermography. Morphologic features were scored and patients were categorized according to the guidelines of EULAR Study group on Microcirculation in Rheumatic Diseases. TG of the hand was performed before, directly and ten minutes after a cold challenge test. Baseline images and rewarming curves were analyzed. Results: Capillary abnormalities with NC were found in all SRP patients (9/9) and in 48% (10/21) of PRP patients. Out of 10 PRP patients with altered capillary morphology, 9 (90%) had a cardiovascular disease. For all patients mean temperature was significantly higher 10 minutes after cold induction than before (p < 0,01). The gradient of the rewarming curve was significantly lower in patients with SRP compared to PRP patients (p = 0.015). Conclusions: Nailfold capillaroscopy and thermography can reliably be used to measure microvascular damage and dysfunction. Additional thermography can assist in differentiating between PRP and SRP, especially in elderly patients or in presence of a cardiovascular disease. Keywords: Raynaud’s phenomenon; Nailfold capillaroscopy; Thermography

Non-Invasive Laser Doppler Opportunities in the Determination of Microcirculation Disturbances in the Patients with Diffuse Liver Disease

10.12737/2906 ◽  
2014 ◽  
Vol 8 (1) ◽  
pp. 1-6
Author(s):  
Гельт ◽  
T. Gelt ◽  
Борсуков ◽  
A. Borsukov
Keyword(s):  
Liver Disease ◽  
Laser Doppler ◽  
Doppler Imaging ◽  
Laser Doppler Imaging ◽  
Disease Course ◽  
Reliable Technique ◽  
Diffuse Liver Disease ◽  
Non Invasive ◽  
Diffuse Liver Diseases

Currently, it is necessary to find additional reliable technique (and without prejudice to the health of the patient with diffuse liver disease) to determine the stage of the disease, to quickly evaluate the degree of fi-brosis, including dynamics, as well as to predict the further course of the disease. It is known that changes in patients with diffuse liver disease at the vascular level are systemic in nature. Identification of these changes may help predict disease course, the possibility of the therapy revising. Clinical perspectives, the benefits of using non-invasive laser Doppler imaging as a method of diagnosis of the microvasculature in patients with diffuse liver diseases are discussed in this paper. 40 patients with alcoholic liver cirrhosis, with steatohepatitis mixed etiology, viral hepatitis &#34;B&#34; and &#34;C&#34; of varying degrees of activity, which conducted the study of microcirculation using non-invasive laser Doppler were examined.

Relationship between peripheral and coronary function using laser Doppler imaging and transthoracic echocardiography

2008 ◽  
Vol 115 (9) ◽  
pp. 295-300 ◽  
Author(s):  
Faisel Khan ◽  
Dean Patterson ◽  
Jill J.F. Belch ◽  
Kumiko Hirata ◽  
Chim C. Lang
Keyword(s):  
Sodium Nitroprusside ◽  
Transthoracic Echocardiography ◽  
Vascular Function ◽  
Healthy Subjects ◽  
Laser Doppler ◽  
Doppler Imaging ◽  
Invasive Technique ◽  
Laser Doppler Imaging ◽  
Vascular Conductance ◽  
Cutaneous Vascular Conductance

Vascular dysfunction in the coronary and peripheral circulations is an early prognostic marker of future cardiovascular events. Measurements of coronary and peripheral vascular function in resistance vessels can be made, but rely on invasive procedures, which make them unsuitable for routine application. An assessment of the direct correlation between vascular responses in skin and coronary vessels has not been made previously. In 27 normal healthy subjects (18–55 years of age), we examined the relationship between peripheral and coronary vascular function. Cutaneous perfusion was measured using the non-invasive technique of laser Doppler imaging during iontophoresis of acetylcholine and sodium nitroprusside, and cutaneous vascular conductance was calculated (laser Doppler perfusion/mean arterial pressure). Coronary flow reserve was measured using transthoracic echocardiography during intravenous adenosine infusion. Mean diastolic velocities were measured at baseline and peak hyperaemic conditions from the Doppler signal recordings. CVR (coronary velocity reserve) was defined as the ratio of hyperaemic to basal mean diastolic velocities. There were significant positive correlations between CVR and cutaneous vascular conductance for acetylcholine (r=0.399, P=0.039) and sodium nitroprusside (r=0.446, P=0.020). These results support the idea that peripheral measurements of skin blood flow are representative of generalized microvascular function including that of the coronary circulation in normal healthy subjects.

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