scholarly journals 0878 Association of Obstructive Sleep Apnea with Internalizing Symptoms vs. Externalizing Behaviors in Adolescents with Attention Deficit Hyperactivity Disorder

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A334-A335
Author(s):  
K Puzino ◽  
S L Calhoun ◽  
F He ◽  
S Toth ◽  
A N Vgontzas ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Attention Deficit ◽  
Internalizing Symptoms ◽  
Externalizing Behaviors ◽  
Behavioral Outcomes ◽  
Periodic Limb Movements ◽  
Hyperactivity Disorder ◽  
Obstructive Sleep

Abstract Introduction Attention deficit hyperactivity disorder (ADHD) in children has been associated with insomnia, obstructive sleep apnea (OSA), and abnormal periodic limb movements (PLMS). However, there is lack of data examining the contribution of OSA to ADHD-related internalizing symptoms and externalizing behaviors in adolescents. Methods We studied the Penn State Child Cohort, a random general population sample of 700 children (8.7±1.7y), of whom 421 were followed-up 8.3 years later during adolescence (17.0±2.3y, 53.9% male). All adolescents underwent a 9-hour PSG, clinical history and physical examination. ADHD was ascertained by a parent- or self-report of having been diagnosed with ADHD. OSA was defined as an apnea hypopnea index (AHI) of ≥2 events per hour of sleep, while a periodic limb movement index (PLMI) ≥5 events per hour of sleep was indicative of PLMS. Controls, OSA-alone, ADHD-alone and ADHD+OSA were identified. The Child or Adult Behavior Checklist were used to ascertain internalizing and externalizing behaviors. Multivariable-adjusted models controlled for sex, race, age, and body mass index (BMI) percentile. Results As compared to controls, adolescents with ADHD-alone or ADHD+OSA had significantly greater externalizing behaviors (p<0.001), inattention (p<0.001) and thought problems (p<0.001). While adolescents with ADHD-alone had higher internalizing symptoms (p=0.021), specifically withdrawn-depression (p<0.01), adolescents with ADHD+OSA had more somatic problems than controls (p=0.048). There were no statistically significant differences in behavioral outcomes between controls and adolescents with OSA-alone or between adolescents with ADHD-alone and ADHD+OSA. Conclusion Adolescents with comorbid ADHD and OSA do not present with worse behavioral outcomes than those with ADHD alone. Future studies should examine whether the progression of these adolescents into young adulthood differs in terms of their behavioral outcomes and development of mental health disorders. Support National Institutes of Health (R01HL136587, R01HL97165, R01HL63772, UL1TR000127)

Attention-deficit/hyperactivity disorder with obstructive sleep apnea: A treatment outcome study

2007 ◽  
Vol 8 (1) ◽  
pp. 18-30 ◽  
Author(s):  
Yu-Shu Huang ◽  
Christian Guilleminault ◽  
Hsueh-Yu Li ◽  
Chien-Ming Yang ◽  
Yu-Yu Wu ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Obstructive Sleep Apnea ◽  
Treatment Outcome ◽  
Sleep Apnea ◽  
Attention Deficit ◽  
Outcome Study ◽  
Hyperactivity Disorder ◽  
Obstructive Sleep

scholarly journals 0900 Obstructive Sleep Apnea Severity, Symptoms Of Attention Deficit Hyperactivity Disorder And Other Comorbid Psychiatric Disorders In Children And Adolescents: A Retrospective Data Analysis

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A342-A343
Author(s):  
M Skoulos ◽  
K Sedky ◽  
D Bennett
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Children And Adolescents ◽  
Psychiatric Disorders ◽  
Attention Deficit ◽  
Apnea Hypopnea Index ◽  
Comorbid Psychiatric Disorders ◽  
Hyperactivity Disorder ◽  
Obstructive Sleep

Abstract Introduction Children and adolescents with obstructive sleep apnea (OSA) are often diagnosed with attention deficit hyperactivity disorder (ADHD). However, the connection between the severity of Apnea/Hypopnea Index (AHI) and ADHD is controversial with research evidence pointing in opposing directions. Methods A retrospective study was conducted in a pediatric sleep center at a university hospital setting to investigate the effect between AHI severity, ADHD and/or other comorbid psychiatric disorders. One hundred and thirty-eight participants between the age of 6 and 18 were examined in terms of AHI severity level and their correlation with scores from the Child Behavior Checklist (CBCL) using SPSS program. Results A negative correlation between AHI scores and Attention Problems for the entire group of participants was found. Additionally, female adolescents had positive correlations between AHI scores and several affective disorder variables from the CBCL, while male adolescents had negative correlations between AHI levels and several CBCL scores that are typically associated with ADHD and Anxiety disorders. Conclusion This study suggests a relationship between OSA severity and psychiatric conditions. However, this relationship can vary depending on age, gender and AHI severity. More research is required to understand this relationship. Support Chervin, R.D. How many children with ADHD have sleep apnea or periodic leg movements on polysomnography? Sleep. 2005: 28(9): 1041-1042. Sedky K, Bennett DS, Carvalho KS. Attention deficit hyperactivity disorder and sleep disordered breathing in pediatric populations: A meta-analysis. Sleep Medicine Reviews. 2014; 18: 349-356

scholarly journals The Link between Pediatric Obstructive Sleep Apnea (OSA) and Attention Deficit Hyperactivity Disorder (ADHD)

Children ◽  
2021 ◽  
Vol 8 (9) ◽  
pp. 824
Author(s):  
Gino Luis Urbano ◽  
Bea Janine Tablizo ◽  
Youmna Moufarrej ◽  
Mary Anne Tablizo ◽  
Maida Lynn Chen ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Attention Deficit ◽  
Sleep Disordered Breathing ◽  
Adhd Symptoms ◽  
Hyperactivity Disorder ◽  
Obstructive Sleep ◽  
Osa Treatment ◽  
Disordered Breathing

Obstructive sleep apnea (OSA) is a form of sleep-disordered breathing that affects up to 9.5% of the pediatric population. Untreated OSA is associated with several complications, including neurobehavioral sequelae, growth and developmental delay, cardiovascular dysfunction, and insulin resistance. Attention-deficit/hyperactivity disorder (ADHD) is among the neurobehavioral sequelae associated with OSA. This review aims to summarize the research on the relationship between OSA and ADHD and investigate the impacts of OSA treatment on ADHD symptoms. A literature search was conducted on electronic databases with the key terms: “attention deficit hyperactivity disorder” or “ADHD”, “obstructive sleep apnea” or “OSA”, “sleep disordered breathing”, and “pediatric” or “children”. Review of relevant studies showed adenotonsillectomy to be effective in the short-term treatment of ADHD symptoms. The success of other treatment options, including continuous positive airway pressure (CPAP), in treating ADHD symptoms in pediatric OSA patients has not been adequately evaluated. Further studies are needed to evaluate the long-term benefits of surgical intervention, patient factors that may influence treatment success, and the potential benefits of other OSA treatment methods for pediatric ADHD patients.

scholarly journals Periodic limb movements in patients with obstructive sleep apnea syndrome

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xiaobo Zhou ◽  
Bo Zhou ◽  
Zhe Li ◽  
Qiao Lu ◽  
Shaoping Li ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Periodic Limb Movements ◽  
Limb Movements ◽  
Factors Associated ◽  
Obstructive Sleep ◽  
Apnea Syndrome

AbstractThe aim of the study was to assess the factors associated with periodic limb movements during sleep (PLMS) among obstructive sleep apnea syndrome (OSAS) patients and identify the role of PLMS in patients with OSAS. 303 adult patients with OSAS were included in the study. All patients completed physical examination, Epworth sleepiness scale (ESS), and polysomnography. Diagnosis of PLMS was made if the periodic leg movements index (PLMI) was ≥ 15. Chi-square test, ANOVA, univariate and multivariate logistic regression analyses were conducted to identify factors associated with PLMS among OSAS patients. Statistical analyses were performed with SPSS 26.0 for mac. Statistically significant difference was considered if P value < 0 .05. Among the 303 adult patients with OSAS, 98 patients had significant PLMS and the other 205 had no significant PLMS. Compared with OSAS patients without PLMS, OSAS patient with PLMS were older, had shorter REM duration and greater apnea–hypopnea index (AHI) (P < 0.05). The study suggests that PLMS is a matter of concern among patients with OSAS. A better understanding of the role of PLMS among OSAS patients could be useful in better recognition, intervention and treatment of OSAS.

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