scholarly journals Effects of Tiagabine on Slow Wave Sleep and Arousal Threshold in Patients With Obstructive Sleep Apnea

SLEEP ◽  
2016 ◽  
Vol 40 (2) ◽  
Author(s):  
Luigi Taranto-Montemurro ◽  
Scott A. Sands ◽  
Bradley A. Edwards ◽  
Ali Azarbarzin ◽  
Melania Marques ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Slow Wave ◽  
Slow Wave Sleep ◽  
Arousal Threshold ◽  
Obstructive Sleep

nCPAP Treatment of Obstructive Sleep Apnea Increases Slow Wave Sleep in Prefrontal EEG

2007 ◽  
Vol 38 (3) ◽  
pp. 148-154 ◽  
Author(s):  
Veera Eskelinen ◽  
Toomas Uibu ◽  
Sari-Leena Himanen
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Treatment Period ◽  
Slow Wave ◽  
Slow Wave Sleep ◽  
Sleep Stage ◽  
Sleep Eeg ◽  
Sleep Stages ◽  
Obstructive Sleep ◽  
Sleep Stage Scoring

According to standard sleep stage scoring, sleep EEG is studied from the central area of parietal lobes. However, slow wave sleep (SWS) has been found to be more powerful in frontal areas in healthy subjects. Obstructive sleep apnea syndrome (OSAS) patients often suffer from functional disturbances in prefrontal lobes. We studied the effects of nasal Continuous Positive Airway Pressure (nCPAP) treatment on sleep EEG, and especially on SWS, in left prefrontal and central locations in 12 mild to moderate OSAS patients. Sleep EEG was recorded by polysomnography before treatment and after a 3 month nCPAP treatment period. Recordings were classified into sleep stages. No difference was found in SWS by central sleep stage scoring after the nCPAP treatment period, but in the prefrontal lobe all night S3 sleep stage increased during treatment. Furthermore, prefrontal SWS increased in the second and decreased in the fourth NREM period. There was more SWS in prefrontal areas both before and after nCPAP treatment, and SWS increased significantly more in prefrontal than central areas during treatment. Regarding only central sleep stage scoring, nCPAP treatment did not increase SWS significantly. Frontopolar recording of sleep EEG is useful in addition to central recordings in order to better evaluate the results of nCPAP treatment.

scholarly journals Effect of Interaction Between Slow Wave Sleep and Obstructive Sleep Apnea on Insulin Resistance: A Large-scale Study

2020 ◽  
Author(s):  
Weijun Huang ◽  
Xiaoting Wang ◽  
Yuenan Liu ◽  
Xinyi Li ◽  
Yupu Liu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Slow Wave ◽  
Large Scale ◽  
Slow Wave Sleep ◽  
Harmful Effect ◽  
Joint Effect ◽  
Obstructive Sleep ◽  
The Status

Abstract Objectives: Slow wave sleep (SWS) and obstructive sleep apnea (OSA) have attracted more and more attention. Their joint effect on insulin resistance (IR) remains to be further studied. This study explored whether less SWS influences the relationship between OSA and IR.Methods: We enrolled potential participants in our sleep center from 2007 to 2019. We collected demographic and clinical characteristics and gauged the IR status. SWS was derived from polysomnography data. Logistic regression analyses were used to reveal the associations between SWS and IR.Results: In all, 6966 participants (5709 OSA and 1257 primary snoring [PS] subjects) were enrolled. Less SWS increases the risk of IR in OSA patients but not in PS patients. OSA patients with SWS < 6.5% were more likely to have IR than those with SWS > 21.3%. OSA was an independent risk factor for IR after adjusting for all potential confounding factors. In stratified analyses according to the percentage of SWS, patients with OSA with SWS < 6.5% had 38.2% higher odds of IR than the PS group after adjusting for all potential confounders. Conclusions: Less SWS is associated with higher odds for IR in OSA patients but not in PS patients. OSA is independently correlated with IR. In addition, OSA combined with an extreme lack of SWS has a more harmful effect on the status of IR than OSA itself.

scholarly journals Interaction Between Slow Wave Sleep and Obstructive Sleep Apnea in Prevalent Hypertension

Hypertension ◽  
2020 ◽  
Vol 75 (2) ◽  
pp. 516-523 ◽  
Author(s):  
Rong Ren ◽  
Naima Covassin ◽  
Ye Zhang ◽  
Fei Lei ◽  
Linghui Yang ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Slow Wave ◽  
Slow Wave Sleep ◽  
Obstructive Sleep

scholarly journals 0573 Slow Wave Sleep Is Associated With An Increased Prevalence Of Hypertension In Patients With Obstructive Sleep Apnea

SLEEP ◽  
2018 ◽  
Vol 41 (suppl_1) ◽  
pp. A213-A213
Author(s):  
R Ren ◽  
Y Zhang ◽  
L Yang ◽  
J Zhou ◽  
L Tan ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Slow Wave ◽  
Slow Wave Sleep ◽  
Obstructive Sleep

Reversibility of deficient sleep entrained growth hormone secretion in a boy with achondroplasia and obstructive sleep apnea

1987 ◽  
Vol 116 (1) ◽  
pp. 95-101 ◽  
Author(s):  
Steven J. Goldstein ◽  
Richard H. K. Wu ◽  
Michael J. Thorpy ◽  
Robert J. Shprintzen ◽  
Robert E. Marion ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Slow Wave ◽  
Slow Wave Sleep ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Hormone Release ◽  
Growth Hormone Release ◽  
Obstructive Sleep

Abstract. Obstructive sleep apnea may lead to disordered sleep architecture and impair the physiologic slow wave sleep related growth hormone release. Obstructive sleep apnea occurs with craniofacial syndromes and in children with airway narrowing, pharyngeal hypoplasia, tonsillar adenoidal hypertrophy, micrognathia and achondroplasia. To examine the relationship between disordered sleep and growth hormone release we studied a 9 year old male with achondroplasia, growth failure (3 cm/year) and obstructive sleep apnea. Polysomnography data and a 20 min sampling for sleep entrained growth hormone showed before therapeutic tracheostomy numerous apneic episodes, absent slow wave sleep and abnormal low growth hormone secretion during sleep. Normalized slow wave sleep entrained growth hormone secretion after tracheostomy led to a sustained increase in growth rate. Normal growth rate (> 5 cm/year) continues 2 years after tracheostomy. We conclude that obstructive sleep apnea may impair sleep related growth hormone release. Obstructive sleep apnea may be a useful model for other diseases in which growth failure and sleep disturbances are linked.

scholarly journals Slow-wave sleep is associated with incident hypertension in patients with obstructive sleep apnea: a cross-sectional study

2020 ◽  
Vol 48 (9) ◽  
pp. 030006052095468
Author(s):  
Jing Zhang ◽  
Yan Zhuang ◽  
Nan-sheng Wan ◽  
Xin Tang ◽  
Wei Zhou ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Slow Wave ◽  
Slow Wave Sleep ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Incident Hypertension ◽  
Obstructive Sleep ◽  
Significant Difference

Objective This study aimed to examine the association between slow-wave sleep ([SWS] N3 stage) and the risk of hypertension in patients with obstructive sleep apnea (OSA) or primary snorers. Methods A retrospective cross-sectional study of 1145 participants who were evaluated for suspected OSA at our Sleep Medical Center were included. Among these participants, 1022 had OSA and 123 were primary snorers. Logistic regression modeling was performed to evaluate the association between the prevalence of hypertension and combined OSA and SWS based on polysomnographic measurements. Results Patients with OSA in the lowest SWS quartile (quartile 1,  < 2.0%) showed a two-fold increased risk of hypertension after adjustment for confounding factors compared with primary snorers (odds ratio, 2.13 [95% confidence interval 1.54–2.06]). In logistic analysis stratified according to SWS quartiles, there was no significant difference in the risk of hypertension between patients with OSA and primary snorers in quartile 1. However, in the highest quartile (quartile 4), SWS was significantly associated with incident hypertension in patients with OSA rather than primary snorers. Conclusion SWS is associated with prevalent hypertension in patients with OSA. Notably, a low proportion of SWS confers a stronger association with incident hypertension than OSA.

scholarly journals Marked Reduction in Obstructive Sleep Apnea Severity in Slow Wave Sleep

2009 ◽  
Vol 05 (06) ◽  
pp. 519-524 ◽  
Author(s):  
Rajeev Ratnavadivel ◽  
Nuy Chau ◽  
Daniel Stadler ◽  
Aeneas Yeo ◽  
R. Doug McEvoy ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Slow Wave ◽  
Marked Reduction ◽  
Slow Wave Sleep ◽  
Obstructive Sleep Apnea Severity ◽  
Obstructive Sleep
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