scholarly journals P020 Reduced duration and continuity of N3 sleep is associated with excessive daytime sleepiness in suspected obstructive sleep apnea patients

2021 ◽  
Vol 2 (Supplement_1) ◽  
pp. A28-A28
Author(s):  
X Chen ◽  
H Korkalainen ◽  
T Leppänen ◽  
A Oksenberg ◽  
J Töyräs ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
Nrem Sleep ◽  
Sleep Time ◽  
Sleep State ◽  
Sleep Continuity ◽  
State Duration ◽  
Obstructive Sleep

Abstract Introduction Excessive daytime sleepiness (EDS) is a common but not universal-accompanying symptom of obstructive sleep apnea (OSA). The mechanisms explaining the presence of EDS in OSA subjects are not fully understood. We hypothesised that characteristic differences in sleep architecture can be quantified with more comprehensive descriptors of sleep continuity in those with and without severe-EDS according to the Multiple Sleep Latency Test (MSLT). Methods 2111 participants with suspected OSA and complaints of daytime sleepiness underwent in-lab diagnostic polysomnography (PSG) and next-day MSLT. Sleep continuity was quantified by calculating the cumulative-frequency relationship of continuous sleep-state duration against proportion of sleep time; and continuous sleep-state duration against absolute sleep time. Results Study contained 368 severe-EDS participants (MSLT≤5min) and 385 non-EDS participants (MSLT>15min). Severe-EDS participants had less Wake After Sleep Onset (48.1±37.7 vs. 68.1±44.2-minutes, p<0.05 [mean±SD]), and greater Total Sleep Time (366.5±50.3 vs. 336.2±58.2-minutes, p<0.05). While total NREM sleep time was similar between groups, severe-EDS participants had less N3 sleep (67.7±38.0 vs. 78.6±32.0-minutes, p<0.05) and more N2 sleep (230.7±59.3 vs. 178.4±45.9-minutes, p<0.05). Moreover, severe-EDS participants had both less cumulative N3 sleep (36.9±2.9 vs. 60.0±3.3-minutes, p<0.05) and a lower proportion of N3 sleep (66.8±5.3% vs. 77.2±4.2%, p<0.05) occurring in periods ≥10mins duration. Discussion Whilst OSA participants with severe EDS have similar NREM sleep time to non-EDS participants; they have less N3 sleep, and N3 sleep periods are less consolidated. These preliminary results suggest that individuals with OSA which disturbs both the quantity and consolidation of N3 sleep are at greater risk of severe EDS.

scholarly journals Risk of obstructive sleep apnea, excessive daytime sleepiness and depressive symptoms in a Nigerian elderly population

Sleep Science ◽  
2016 ◽  
Vol 9 (2) ◽  
pp. 106-111 ◽  
Author(s):  
Michael B. Fawale ◽  
Olanrewaju Ibigbami ◽  
Ishaq Ismail ◽  
Adekunle F. Mustapha ◽  
Morenikeji A. Komolafe ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Depressive Symptoms ◽  
Sleep Apnea ◽  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
Elderly Population ◽  
Obstructive Sleep

scholarly journals Association of TNF-α (-308G/A) Gene Polymorphism with Circulating TNF-α Levels and Excessive Daytime Sleepiness in Adults with Coronary Artery Disease and Concomitant Obstructive Sleep Apnea

2021 ◽  
Vol 10 (15) ◽  
pp. 3413
Author(s):  
Afrouz Behboudi ◽  
Tilia Thelander ◽  
Duygu Yazici ◽  
Yeliz Celik ◽  
Tülay Yucel-Lindberg ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Obstructive Sleep Apnea ◽  
Coronary Artery ◽  
Sleep Apnea ◽  
Gene Polymorphism ◽  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
Obstructive Sleep ◽  
Tnf Α ◽  
Artery Disease

Obstructive sleep apnea (OSA) is common in patients with coronary artery disease (CAD), in which inflammatory activity has a crucial role. The manifestation of OSA varies significantly between individuals in clinical cohorts; not all adults with OSA demonstrate the same set of symptoms; i.e., excessive daytime sleepiness (EDS) and/or increased levels of inflammatory biomarkers. The further exploration of the molecular basis of these differences is therefore essential for a better understanding of the OSA phenotypes in cardiac patients. In this current secondary analysis of the Randomized Intervention with Continuous Positive Airway Pressure in CAD and OSA (RICCADSA) trial (Trial Registry: ClinicalTrials.gov; No: NCT 00519597), we aimed to address the association of tumor necrosis factor alpha (TNF-α)-308G/A gene polymorphism with circulating TNF-α levels and EDS among 326 participants. CAD patients with OSA (apnea–hypopnea-index (AHI) ≥ 15 events/h; n = 256) were categorized as having EDS (n = 100) or no-EDS (n = 156) based on the Epworth Sleepiness Scale score with a cut-off of 10. CAD patients with no-OSA (AHI < 5 events/h; n = 70) were included as a control group. The results demonstrated no significant differences regarding the distribution of the TNF-α alleles and genotypes between CAD patients with vs. without OSA. In a multivariate analysis, the oxygen desaturation index and TNF-α genotypes from GG to GA and GA to AA as well as the TNF-α-308A allele carriage were significantly associated with the circulating TNF-α levels. Moreover, the TNF-α-308A allele was associated with a decreased risk for EDS (odds ratio 0.64, 95% confidence interval 0.41–0.99; p = 0.043) independent of age, sex, obesity, OSA severity and the circulating TNF-α levels. We conclude that the TNF-α-308A allele appears to modulate circulatory TNF-α levels and mitigate EDS in adults with CAD and concomitant OSA.

scholarly journals Response to the letter entitled “Obstructive sleep apnea, excessive daytime sleepiness, and adherence to antihypertensive treatment: Questionnaire survey”

2017 ◽  
Vol 19 (12) ◽  
pp. 1384-1384
Author(s):  
Camila Gosenheimer Righi ◽  
Denis Martinez ◽  
Sandro Cadaval Gonçalves ◽  
Miguel Gus ◽  
Leila Beltrami Moreira ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
Questionnaire Survey ◽  
Antihypertensive Treatment ◽  
Obstructive Sleep

scholarly journals Excessive Daytime Sleepiness in Depression and Obstructive Sleep Apnea: More Than Just an Overlapping Symptom

2021 ◽  
Vol 12 ◽  
Author(s):  
Danwei Zhang ◽  
Zhen Zhang ◽  
Huihua Li ◽  
Kaimo Ding
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
General Population ◽  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
Health Concern ◽  
Therapeutic Effects ◽  
Obstructive Sleep ◽  
Significant Public Health ◽  
The Relationship

Excessive daytime sleepiness (EDS) is a significant public health concern, with obstructive sleep apnea (OSA) being a common cause, and a particular relationship exists with the severity of depression. A literature search on OSA, depression, and EDS was performed in PubMed. The chosen evidence was limited to human studies. Available evidence was systematically reviewed to ascertain the association of EDS with depression and OSA according to the general population and some specific population subgroups. In addition, effectiveness of continuous positive airway pressure (CPAP) was analyzed as a standard therapy for improving EDS and depression in patients with OSA. In the general population, patients with OSA, and some other subpopulations, the review contributed to: (1) delineating the prevalence of EDS; (2) substantiating the relationship of EDS and depression; (3) presenting the relationship between EDS and OSA; and (4) revealing that the duration of CPAP is crucial for its therapeutic effects in improving EDS and depressive symptoms in patients with OSA.

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