0358 RESIDUAL EFFECTS OF ESZOPICLONE AND PLACEBO IN HEALTHY ELDERLY SUBJECTS, A RANDOMIZED DOUBLE BLIND STUDY

With increasing age, a number of physiological changes take place which are reflected in immune and bowel function. These changes may relate to the commonly assumed age-related changes in intestinal microbiota; most noticeably a reduction in bifidobacteria. The current study aimed at modifying the intestinal microbiota with a potential synbiotic on selected immune and microbiota markers. Healthy elderly subjects were randomised to consume during 2 weeks either a placebo (sucrose) or a combination of lactitol andLactobacillus acidophilusNCFM twice daily in a double-blind parallel trial. After the intervention, stool frequency was higher in the synbiotic group than in the placebo group and a significant increase in faecalL. acidophilusNCFM levels was observed in the synbiotic group, after baseline correction. In contrast to the generally held opinion, the study subjects had faecalBifidobacteriumlevels that were similar to those reported in healthy young adults. These levels were, nevertheless, significantly increased by the intervention. Levels of SCFA were not changed significantly. Of the measured immune markers, PGE2levels were different between treatments and IgA levels changed over time. These changes were modest which may relate to the fact that the volunteers were healthy. Spermidine levels changed over time which may suggest an improved mucosal integrity and intestinal motility. The results suggest that consumption of lactitol combined withL. acidophilusNCFM twice daily may improve some markers of the intestinal microbiota composition and mucosal functions.

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Herbal formulation in the treatment of age-related cognitive decline in elderly subjects: A double blind study from India

Neurobiology of Aging ◽

10.1016/s0197-4580(00)82085-0 ◽

2000 ◽

Vol 21 ◽

pp. 166

Author(s):

Meera Vaswani ◽

C. Andrade ◽

S. Gowda ◽

S.K. Chakarvorty

Keyword(s):

Cognitive Decline ◽

Blind Study ◽

Elderly Subjects ◽

Double Blind Study ◽

Double Blind ◽

Herbal Formulation ◽

Age Related ◽

Age Related Cognitive Decline

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Double-blind study of the effects of l-acetyl-carnitine on evoked potentials in elderly subjects without mental deterioration

Pharmacological Research Communications ◽

10.1016/s0031-6989(88)80466-1 ◽

1988 ◽

Vol 20 ◽

pp. 336

Author(s):

G. Russo ◽

P. Conte ◽

L. Sallusto

Keyword(s):

Evoked Potentials ◽

Blind Study ◽

Elderly Subjects ◽

Double Blind Study ◽

Double Blind ◽

Mental Deterioration

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A RANDOMISED DOUBLE-BLIND CLINICAL STUDY TO EVALUATE AND COMPARE THE EFFECTS OF VRIDDADARU RASAYANA WITH BHARGAVAPROKTA RASAYANA ON AGEING IN APPARENTLY HEALTHY ELDERLY SUBJECTS

International Journal of Ayurveda and Pharma Research ◽

10.47070/ijapr.v8i11.1678 ◽

2020 ◽

pp. 13-23

Author(s):

Manasa H P ◽

Yogeesha Acharya ◽

Sandesh Kumar

Keyword(s):

Quality Of Life ◽

Clinical Study ◽

The Elderly ◽

Elderly Subjects ◽

Double Blind ◽

General Body ◽

Healthy Elderly ◽

Healthy Elderly Subjects ◽

Apparently Healthy

According to estimation, India currently has 6.7% over 65 years of age, which is expected to increase to 20% by the year 2050. As growing old is a part of the life cycle, the effect of time is bound to happen and is unavoidable. The Kalajajara is a Swabhavika vyadhi, wherein, it is clearly mentioned that Swabhava balapravritta vyadhis being Yapya, can be managed through Bhojana, Paana, and Rasayana. Vriddadaru Rasayana is one such Rasayana mentioned in Gadanigraha especially for the elderly to promote healthy ageing and helping to prevent old age problems. Aims and objectives: To assess the effect of Vriddadaru Rasayana in improving the general body health and quality of life in the apparently healthy elderly subjects. Methodology– A Randomized double blind clinical study where 20 healthy elderly subjects were administered with Vriddadaru Rasayana for a period of 12 weeks. Observations and Results- Vriddadaru rasayana showed improvement in Ayurvedic parameters like Twakparushata, Slataasti, Slata sandhi, Utasahahani and Parakramahani but when compared with regard to objective parameters Vriddadaru rasayana showed significant values in DHEAS levels and 6MWT. Conclusion: Vriddadaru does Vatashamana, balancing the Doshas, increasing the Utsaha and Parakrama and helps in improving the Agni thus helping in Dhatuposhana in the elderly.

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