Differential Effects of Cefmetazole Sodium on the Reproductive System of Infant and Pubertal Male Rats

1989 ◽  
Vol 13 (1) ◽  
pp. 146-155
Author(s):  
J. B. MOE ◽  
K. SOTANI ◽  
J. MANABE ◽  
N. IKEGAMI ◽  
H. TANASE ◽  
...  
Keyword(s):  
Reproductive System ◽  
Male Rats ◽  
Differential Effects

The effect of female rat proximity on the reproductive system of male rats

1972 ◽  
Vol 9 (3) ◽  
pp. 401-407 ◽  
Author(s):  
K. Purvis ◽  
N.B. Haynes
Keyword(s):  
Reproductive System ◽  
Male Rats ◽  
Female Rat

Effects of hazelnut supplemented diet on doxorubicin‐induced damage of reproductive system in male rats

2021 ◽  
Author(s):  
Hanife Kara ◽  
Asım Orem ◽  
Esin Yulug ◽  
Fulya Balaban Yucesan ◽  
Gokcen Kerimoglu ◽  
...  
Keyword(s):  
Reproductive System ◽  
Male Rats

scholarly journals Effects of Stress on the Reproductive System of Male Rats and Mice

1983 ◽  
Vol 10 (2) ◽  
pp. 95-101 ◽  
Author(s):  
A. V. McGrady ◽  
J. Chakraborty
Keyword(s):  
Reproductive System ◽  
Male Rats ◽  
Effects Of Stress ◽  
Rats And Mice

scholarly journals Effects of Leucaena leucocephala (Lamk.) Shoot Tips Plus Young Leaf Extract Containing Mimosine on Reproductive System of Male Rats

2018 ◽  
Vol 36 (3) ◽  
pp. 1062-1069 ◽  
Author(s):  
Jaturon Burawat ◽  
Nongnut Uabandit ◽  
Supatcharee Arun ◽  
Somsak Nualkaew ◽  
Sitthichai Iamsaard
Keyword(s):  
Reproductive System ◽  
Leucaena Leucocephala ◽  
Leaf Extract ◽  
Shoot Tips ◽  
Young Leaf ◽  
Male Rats

Assessment of the oxidative stress effects on the reproductive system of young male rats to n-butylparaben

2018 ◽  
Vol 295 ◽  
pp. S133-S134
Author(s):  
E. Schreiber Bru ◽  
T. Garcia ◽  
M. Torrente ◽  
V. Kumar ◽  
R.P. Sharma ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reproductive System ◽  
Young Male ◽  
Male Rats ◽  
Stress Effects

Favourable effect of β‐glucan treatment against cisplatin‐induced reproductive system damage in male rats

Andrologia ◽  
2019 ◽  
Vol 51 (9) ◽  
Author(s):  
Kürşat Kaya ◽  
Osman Ciftci ◽  
Muhterem Aydın ◽  
Aslı Cetin ◽  
Neşe Basak
Keyword(s):  
Reproductive System ◽  
Male Rats ◽  
Favourable Effect

scholarly journals High-fat diet-induced and genetically inherited obesity differentially alters DNA methylation profile in the germline of adult male rats

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Sharvari S. Deshpande ◽  
Harishankar Nemani ◽  
Gandhimathi Arumugam ◽  
Avinash Ravichandran ◽  
Nafisa H. Balasinor
Keyword(s):  
Dna Methylation ◽  
Real Time ◽  
Real Time Pcr ◽  
High Fat Diet ◽  
Male Rats ◽  
Global Dna Methylation ◽  
High Fat ◽  
Differential Effects ◽  
Male Germline ◽  
Embryo Loss

Abstract Background Paternal obesity has been associated with reduced live birth rates. It could lead to inheritance of metabolic disturbances to the offspring through epigenetic mechanisms. However, obesity is a multifactorial disorder with genetic or environmental causes. Earlier we had demonstrated differential effects of high-fat diet-induced obesity (DIO) and genetically inherited obesity (GIO) on metabolic, hormonal profile, male fertility, and spermatogenesis using two rat models. The present study aimed to understand the effect of DIO and GIO on DNA methylation in male germline, and its subsequent effects on the resorbed (post-implantation embryo loss) and normal embryos. First, we assessed the DNA methylation enzymatic machinery in the testis by Real-Time PCR, followed global DNA methylation levels in spermatozoa and testicular cells by ELISA and flow cytometry, respectively. Further, we performed Methylation Sequencing in spermatozoa for both the groups. Sequencing data in spermatozoa from both the groups were validated using Pyrosequencing. Expression of the differentially methylated genes was assessed in the resorbed and normal embryos sired by the DIO group using Real-Time PCR for functional validation. Results We noted a significant decrease in Dnmt transcript and global DNA methylation levels in the DIO group and an increase in the GIO group. Sequencing analysis showed 16,966 and 9113 differentially methylated regions in the spermatozoa of the DIO and GIO groups, respectively. Upon pathway analysis, we observed genes enriched in pathways involved in embryo growth and development namely Wnt, Hedgehog, TGF-beta, and Notch in spermatozoa for both the groups, the methylation status of which partially correlated with the gene expression pattern in resorbed and normal embryos sired by the DIO group. Conclusion Our study reports the mechanism by which diet-induced and genetically inherited obesity causes differential effects on the DNA methylation in the male germline that could be due to a difference in the white adipose tissue accumulation. These differences could either lead to embryo loss or transmit obesity-related traits to the offspring in adult life.

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