Effects of Leucaena leucocephala (Lamk.) Shoot Tips Plus Young Leaf Extract Containing Mimosine on Reproductive System of Male Rats

The present work was undertaken to evaluate antidiarrheal activity of ethanolic leaf extract of Dissotis multiflora (Sm) Triana (D. multiflora) on Shigella flexneri-induced diarrhea in Wistar rats and its subacute toxicity. Diarrhea was induced by oral administration of 1.2 × 109 cells/mL S. flexneri to rats. Antidiarrheal activity was investigated in rats with the doses of 111.42 mg/kg, 222.84 mg/kg, and 445.68 mg/kg. The level of biochemical parameters was assessed and organs histology examined by 14 days’ subacute toxicity. S. flexneri stool load decreased significantly in dose-dependent manner. The level of ALT increased (p<0.05) in male rats treated with the dose of 445.68 mg/kg while creatinine level increased in rats treated with both doses. In female rats, a significant decrease (p<0.05) of the level of AST and creatinine was noted in rats treated with the dose of 222.84 mg/kg of D. multiflora. Histological exams of kidney and liver of treated rats showed architectural modifications at the dose of 445.68 mg/kg. This finding suggests that D. multiflora leaf extract is efficient against diarrhea caused by S. flexneri but the treatment with doses lower than 222.84 mg/kg is recommended while further study is required to define the exact efficient nontoxic dose.

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Toxicological evaluation of hydroethanol leaf extract of Pupalia lappacea (Linn.) Juss. (Amaranthaceae) in rodents

Drug Metabolism and Personalized Therapy ◽

10.1515/dmdi-2021-0115 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Murtala Akanji Abdullahi ◽

Elijah Oladapo Oyinloye ◽

Akinyinka Alabi ◽

Aderonke Adeyinka Aderinola ◽

Luqman Opeyemi Ogunjimi ◽

...

Keyword(s):

Leaf Extract ◽

Density Lipoprotein ◽

Serum Testosterone ◽

Female Rats ◽

Male Rats ◽

Laboratory Animals ◽

Serum Testosterone Level ◽

Control Group ◽

Toxicological Evaluation ◽

Liver And Kidney

Abstract Objectives Several studies have established the ethnobotanical benefits of Pupalia lappacea (PL) in laboratory animals without extensive toxicological evaluation of its safety profiles. Thus, an extensive toxicological investigation of sub-chronic oral administration of the hydroethanol leaf extract of P. lappacea in rodents was carried out in this study. Methods Different groups of rats were treated orally with the extract (10, 50 and 250 mg/kg) daily for 90 consecutive days. The control group received distilled water (10 mL/kg). After 90 days, some rats were left for additional 30 days without treatment for reversibility study. Blood and organs samples were collected for different evaluations at the end of study periods. Results The extract decreased the bodyweights, feeding and water intakes in female rats. PL increased the weights of the liver and kidney in male rats. PL increased the red blood cell (RBC), packed cell volume (PCV), hemoglobin (Hb), triglycerides (TRIG), cholesterol and high density lipoprotein (HDL) contents in rats. PL (250 mg/kg) significantly reduced the sperm motility and serum testosterone level. Cyto-architectural distortions of the testes, liver and spleen were visible. Conclusions The findings showed that P. lappacea is relatively safe at lower doses but cautions should be taken at higher dose.

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Effects of hazelnut supplemented diet on doxorubicin‐induced damage of reproductive system in male rats

Journal of Food Biochemistry ◽

10.1111/jfbc.13973 ◽

2021 ◽

Author(s):

Hanife Kara ◽

Asım Orem ◽

Esin Yulug ◽

Fulya Balaban Yucesan ◽

Gokcen Kerimoglu ◽

...

Keyword(s):

Reproductive System ◽

Male Rats

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Acute and sub-acute oral toxicity of aqueous whole leaf and green rind extracts of Aloe vera in Wistar rats

BMC Complementary Medicine and Therapies ◽

10.1186/s12906-021-03470-4 ◽

2022 ◽

Vol 22 (1) ◽

Author(s):

Florence Nalimu ◽

Joseph Oloro ◽

Emanuel L. Peter ◽

Patrick Engeu Ogwang

Keyword(s):

Toxicity Test ◽

Wistar Rats ◽

Leaf Extract ◽

Aloe Vera ◽

Female Rats ◽

Male Rats ◽

Aqueous Extracts ◽

Acute Oral Toxicity ◽

Oral Toxicity ◽

Leaf Extracts

Abstract Background Several local communities in Central, Western, Eastern, and Northern regions of Uganda have been using the whole leaf extracts of Aloe vera (L.) Burm. f. (Asphodelaceae) in the treatment of various ailments. Also, several commercial companies sell A. vera as soft drinks in Uganda. However, there are inadequate reports on the toxicities of such preparations. This paper reports the acute and sub-acute oral toxicity of aqueous extracts of whole leaf and green rind of A. vera in Wistar rats. Methods Acute oral toxicity test was carried out in female Wistar rats at doses of 175, 550, 1750, and 5000 mg/kg, p.o. The animals were observed for signs of toxicity for 14 days. Similarly, a sub-acute oral toxicity test was performed in both sexes of rats at doses of 200, 400, and 800 mg/kg, p.o. daily for 28 days. All the groups of animals were monitored for behavioral, morphological, biochemical, and physiological changes, including mortality and compared with respective controls. Body weights were measured weekly while the animals’ relative organ weights, hematological, biochemical, gross, and microscopic pathology were examined on day 29. Results There was no mortality or apparent behavioral changes at the doses tested in acute and sub-acute oral toxicity tests. Thus, the Median Lethal Dose (LD50) of green rind and whole leaf aqueous extracts was above 5000 mg/kg. Gross anatomy revealed that the rats’ relative spleen weight in green rind extract at 200 mg/kg significantly decreased compared to the control group. The creatinine levels in female rats that received green rind extract and the chloride ion levels in male rats administered whole leaf extract were significantly elevated. Conversely, Mean Corpuscular Hemoglobin Concentration (MCHC) levels significantly decreased at lower doses of the green rind extract compared to the control. Histopathology of the kidney revealed the renal interstitium’s inflammation at doses of 200 and 800 mg/kg of the whole leaf extract. Conclusion The findings demonstrated that A. vera green rind and whole leaf extracts are non-toxic at relatively high doses when used for a short duration. Prolonged use of the aqueous whole leaf extract might be associated with kidney toxicity.

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Effects of Stress on the Reproductive System of Male Rats and Mice

Archives of Andrology ◽

10.3109/01485018308987549 ◽

1983 ◽

Vol 10 (2) ◽

pp. 95-101 ◽

Cited By ~ 8

Author(s):

A. V. McGrady ◽

J. Chakraborty

Keyword(s):

Reproductive System ◽

Male Rats ◽

Effects Of Stress ◽

Rats And Mice

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Assessment of the oxidative stress effects on the reproductive system of young male rats to n-butylparaben

Toxicology Letters ◽

10.1016/j.toxlet.2018.06.702 ◽

2018 ◽

Vol 295 ◽

pp. S133-S134

Author(s):

E. Schreiber Bru ◽

T. Garcia ◽

M. Torrente ◽

V. Kumar ◽

R.P. Sharma ◽

...

Keyword(s):

Oxidative Stress ◽

Reproductive System ◽

Young Male ◽

Male Rats ◽

Stress Effects

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Roles of Moringa oleifera Leaf Extract in Improving the Impact of High Dietary Intake of Monosodium Glutamate-Induced Liver Toxicity, Oxidative Stress, Genotoxicity, DNA Damage, and PCNA Alterations in Male Rats

Oxidative Medicine and Cellular Longevity ◽

10.1155/2018/4501097 ◽

2018 ◽

Vol 2018 ◽

pp. 1-11 ◽

Cited By ~ 3

Author(s):

Tarfa Albrahim ◽

Manal Abdulaziz Binobead

Keyword(s):

Oxidative Stress ◽

Dna Damage ◽

Leaf Extract ◽

Liver Toxicity ◽

Monosodium Glutamate ◽

Male Rats ◽

Control Group ◽

Gamma Glutamyl Transferase ◽

Glutamyl Transferase ◽

The Impact

It is common for food to be made more palatable through the use of the flavour enhancer monosodium glutamate, also known as vetsin powder. The purpose of the study described in this paper was to explore how vetsin-induced hepatic toxicity, DNA fragmentation, damage, and oxidative stress modifications could be mitigated with moringa leaf extract (MLE). To that end, 40 male rats were separated into four groups: normal control, positive control or MLE, vetsin, and vetsin combined with MLE. Results indicated that, compared to the control group, the levels of serum alanine aminotransferase (ALT), aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), liver malondialdehyde (MDA), DNA damage, injury, PCNA, and P53 expressions were significantly enhanced by the administration of vetsin (P<0.05). However, the vetsin group had significantly reduced levels of albumin, globulin, total protein, liver glutathione (GSH), superoxide dismutase enzyme (SOD), catalase, and glutathione S-transferase (GST) enzyme activities (P<0.05) by comparison to control. Meanwhile, modifications in liver functions, oxidative stress, DNA damage, liver injury, and PCNA expression were alleviated when vetsin was administered alongside MLE. The authors conclude that vetsin may have many side effects and that MLE can ameliorate biochemical changes, oxidative stress, hepatic injury, PCNA, and P53 alterations induced by vetsin administration.

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Favourable effect of β‐glucan treatment against cisplatin‐induced reproductive system damage in male rats

Andrologia ◽

10.1111/and.13342 ◽

2019 ◽

Vol 51 (9) ◽

Author(s):

Kürşat Kaya ◽

Osman Ciftci ◽

Muhterem Aydın ◽

Aslı Cetin ◽

Neşe Basak

Keyword(s):

Reproductive System ◽

Male Rats ◽

Favourable Effect

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