Assessment of the oxidative stress effects on the reproductive system of young male rats to n-butylparaben

2018 ◽  
Vol 295 ◽  
pp. S133-S134
Author(s):  
E. Schreiber Bru ◽  
T. Garcia ◽  
M. Torrente ◽  
V. Kumar ◽  
R.P. Sharma ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reproductive System ◽  
Young Male ◽  
Male Rats ◽  
Stress Effects

Protective effect ofCymbopogon citratuson hydrogen peroxide-induced oxidative stress in the reproductive system of male rats

2013 ◽  
Vol 59 (6) ◽  
pp. 329-336 ◽  
Author(s):  
Saleh M. Rahim ◽  
Ekhlass M. Taha ◽  
Zaid M. Mubark ◽  
Salam S. Aziz ◽  
K.D. Simon ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Protective Effect ◽  
Reproductive System ◽  
Male Rats

THE EFFECTS OF ALLOXAN DIABETES ON THE REPRODUCTIVE SYSTEM OF YOUNG MALE RATS

1961 ◽  
Vol 38 (3) ◽  
pp. 432-440 ◽  
Author(s):  
Ernest L. Hunt ◽  
Donald W. Bailey
Keyword(s):  
Reproductive System ◽  
Alloxan Diabetes ◽  
Histological Study ◽  
Prostate Gland ◽  
Young Male ◽  
Male Rats ◽  
Testicular Descent ◽  
Subcutaneous Injections ◽  
Severe Diabetes ◽  
Urine Sugar

ABSTRACT Male rats 23 days of age were rendered diabetic by subcutaneous injections of alloxan. Diabetes was determined one week later on the basis of urine sugar concentration. At regular intervals following treatment animals were sacrificed and the testes, seminal vesicles and prostate gland removed for histological study. Severe diabetes resulted in failure of descent of the testes, failure of development of the germinal epithelium and castrate-type accessory organs. A more moderate diabetic condition resulted in delayed testicular descent, delayed onset of spermatogenesis and development of accessory structures. Control rats maintained on an inadequate diet were comparable to the moderate diabetics. Treatment with insulin corrected all the deleterious effects of diabetes on the reproductive system. In diabetic animals, not receiving insulin, treatment with chorionic gonadotrophin resulted in hypertrophy of interstitial cells and some development of accessory structures, but did not bring about testicular descent nor onset of spermatogenesis. Treatment with testosterone stimulated accessory structures, but did not affect testicular descent.

Effects on the reproductive system of young male rats of subcutaneous exposure to n-butylparaben

2017 ◽  
Vol 106 ◽  
pp. 47-57 ◽  
Author(s):  
Tania Garcia ◽  
Elga Schreiber ◽  
Vikas Kumar ◽  
Raju Prasad ◽  
Juan J. Sirvent ◽  
...  
Keyword(s):  
Reproductive System ◽  
Young Male ◽  
Male Rats

Reproductive toxic effects and possible mechanisms of zonisamide in male rats

2019 ◽  
Vol 38 (12) ◽  
pp. 1384-1396 ◽  
Author(s):  
AB Karaduman ◽  
V Kilic ◽  
O Atli-Eklioglu ◽  
M Baysal ◽  
G Aydogan-Kılıc ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reproductive System ◽  
Histopathological Examination ◽  
Sperm Concentration ◽  
Exposure Period ◽  
Toxic Effects ◽  
Male Rats ◽  
Hormonal Changes ◽  
Pathological Findings ◽  
Oxidative Stress Biomarkers

Zonisamide (ZNS) is an anticonvulsant which is used to treat the symptoms of epilepsy. Although it is frequently used during reproductive ages, studies that investigated the effects of ZNS on reproductive system are limited. Therefore, we aimed to assess the effects of ZNS on male reproductive system by oral administration to rats in 25, 50, and 100 mg/kg doses for 28 days. After the exposure period, sperm concentration, motility, morphology, and DNA damage, as biomarkers of reproductive toxic effects, were determined, and histopathological examination of testis was performed. In addition, levels of the hormones that play a role in the regulation of reproductive functions, such as follicle-stimulating hormone, luteinizing hormone (LH), and testosterone were measured and the levels of oxidative stress biomarkers that take part in the reproductive pathologies such as catalase, superoxide dismutase, glutathione, and malondialdehyde, were determined. Reproductive toxic effects related to ZNS administration were shown by the significant decrease of sperm concentration and normal sperm morphology in ZNS groups. Additionally, pathological findings were observed in the testicular tissues of ZNS-administered groups dose dependently. In addition, serum LH and testosterone levels were significantly decreased in the ZNS groups. Decreased catalase activities and increased malondialdehyde levels in ZNS groups were evaluated as oxidative stress findings in the testis tissue. It could be expressed that ZNS administration induced dose-dependent reproductive toxic effects in rats, and pathological findings associated with the reproductive system could be the result of that hormonal changes and testicular oxidative stress, which in turn might be considered as possible mechanisms of male reproductive toxicity.

scholarly journals Toxoplasma gondii: A Possible Inducer of Oxidative Stress in Re-productive System of Male Rats

2020 ◽  
Author(s):  
Ziba HOSEINY ASL NAZARLU ◽  
Mohammad MATINI ◽  
Maryam BAHMANZADEH ◽  
Faeze FOROUGHI-PARVAR
Keyword(s):  
Oxidative Stress ◽  
Toxoplasma Gondii ◽  
Adverse Effects ◽  
Reproductive System ◽  
Male Rats ◽  
Male Rat ◽  
Post Inoculation ◽  
Productive System ◽  
Testis Tissue

Results: After post inoculation, the variations of the OSMs in the testis tissue of infected rats were as follows: a significant decrease of SOD on day 80 (P=0.03), and CAT activity were detected on day 60 and 80 (P=0.04 and P=0.01) respectively.  In addition, GSH (P =0.01) and TAC (P =0.03) concentration were significantly reduced on day 80. On the contrary, the concentration of MDA (P =0.01) was increased 70 days after infection. In addition, consistent changes with the tissue testis were observed in the serum OSMs of infected rats. Conclusion: T. gondii infection caused oxidative stress in testis tissue. Thus, the adverse effects of oxidative stress may affect the male rat reproductive system. 

Effect of Turmeric and Ginger on Lipid Profile in Male Rats Exposed to Oxidative Stress

2019 ◽  
Vol 10 (01) ◽  
Author(s):  
Eman A. Al-Rekabi ◽  
Dheyaa K. Alomer ◽  
Rana Talib Al-Muswie ◽  
Khalid G. Al-Fartosi
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Drinking Water ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Male Rats ◽  
Control Group ◽  
Very Low Density Lipoprotein ◽  
Low Density

The present study aimed to investigate the effect of turmeric and ginger on lipid profile of male rats exposed to oxidative stress induced by hydrogen peroxide H2O2 at a concentration of 1% given with consumed drinking water to male rats. Methods: 200 mg/kg from turmeric and ginger were used, and the animals were treatment for 30 days. Results: the results showed a significant increase in cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipoprotein (VLDL), whereas it explained a significant decrease in high density lipoprotein (HDL) of male rats exposed to oxidative stress when compared with control group. the results showed a significant decrease in cholesterol, triglycerides, (LDL), (VLDL), whereas it explained a significant increase in (HDL) of rats treated with turmeric and ginger at dose 200 mg/kg when compared with male rats exposed to oxidative stress.

UJI AKTIVITAS HEPATOPROTEKTOR KOMBINASI EKSTRAK ETANOL DAUN PANDAN WANGI (Pandanus amaryllifolius roxb) DAN KAYU MANIS (Cinnamomum burmanii) TERHADAP KADAR MDA YANG DIINDUKSI PARASETAMOL

2020 ◽  
pp. 68-73
Author(s):  
Yuni Asri Mulatsih Agami ◽  
Eka Wisnu Kusuma
Keyword(s):  
Oxidative Stress ◽  
Ethanol Extract ◽  
Optimal Dose ◽  
Experimental Methods ◽  
Positive Control ◽  
Negative Control ◽  
Male Rats ◽  
Negative Group ◽  
Ic50 Value ◽  
Dose Combination

Kasus penyakit hati semakin meningkat seiring penggunaan senyawa hepatotoksin salah satunya karena penggunaan parasetamol dengan dosis berlebih. Hal tersebut dapat meningkatkan produksi radikal bebas sehingga memicu terjadinya stress oksidatif yang dapat menimbulkan kerusakan jaringan yang ditandai dengan peningkatan kadar Malondialdehyde (MDA). Stress oksidatif dapat diatasi dengan antioksidan dari berbagai tanaman. Kulit kayu manis memiliki aktivitas antioksidan dengan nilai IC50 53ppm dan daun pandan wangi 39,7%  Penelitian ini bertujuan untuk mengetahui aktivitas kombinasi ekstrak etanol daun pandan wangi dan kayu manis dalam menurunkan kadar MDA. tikus yang diinduksi parasetamol. Penelitian menggunakan metode eksperimental, dilakukan selama 9 hari dengan 30 ekor tikus jantan dibagi menjadi 6 Kelompok, yaitu: Normal diberi aquadest, Kontrol Positif diberi silimarin 100 mg/kgBB, Kontrol Negatif diberi CMC-Na 0,05%, serta 3 kelompok lainnya diberi kombinasi ekstrak daun pandan wangi:kayu manis berturut-turut dosis I (25:75), dosis II (50:50), dosis III (75:25). Semua kelompok diinduksi parasetamol 2,5 g/kgBB pada hari ke-7  setelah 30 menit perlakuan, kecuali kelompok normal. Pada hari ke 9 dilakukan pengukuran kadar MDA dengan metode TBARs menggunakan spektrofotometri. Pemberian kombinasi ekstrak etanol daun pandan wangi dan kayu manis dapat menurunkan kadar MDA dengan kombinasi dosis yang paling optimal adalah 75:25 berdasarkan statistik dengan nilai signifikan 0,000<0,05 dibandingkan dengan kelompok negatif.    Cases of liver disease have increased with the use of hepatotoxin compounds, one of which is due to the use of paracetamol with excessive doses. This can increase the production of free radicals so that it triggers oxidative stress which can cause tissue damage which is characterized by increased levels of Malondialdehyde (MDA). Oxidative stress can be overcome with antioxidants from various plants. Cinnamomum burmanii has antioxidant activity with IC50 value of 53ppm and Pandanus amarrylifolius 39.7%. This study aims to determine the combined activity of ethanol extract of Pandanus amarrylifolius and Cinnamomum burmanii  in reducing MDA levels. Paracetamol-induced rats. Research using experimental methods, conducted for 9 days with 30 male rats divided into 6 groups, namely: Normal given aquadest, Positive Control were given silimarin 100 mg / kgBB, Negative Control was given CMC-Na 0.05%, and 3 other groups were given a combination of Pandanus amarrylifolius extract: Cinnamomum burmanii dose I (25:75), dose II (50:50), dose III (75:25). All groups induced paracetamol 2.5 g / kgBB on the 7th day after 30 minutes of treatment, except the normal group. On the 9th day MDA levels were measured using the TBARs method using spectrophotometry. Giving a combination of Pandanus amarrylifolius and Cinnamomum burmanii ethanol extract can reduce MDA levels with the most optimal dose combination is 75:25 based on statistics with a significant value of 0,000<0.05 compared with the negative group.

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