scholarly journals Modulating the Endoplasmic Reticulum Stress Response with trans-4,5-Dihydroxy-1,2-Dithiane Prevents Chemically Induced Renal Injury In Vivo

2005 ◽  
Vol 88 (2) ◽  
pp. 576-584 ◽  
Author(s):  
Senait Asmellash ◽  
James L. Stevens ◽  
Takaharu Ichimura
Keyword(s):  
Endoplasmic Reticulum ◽  
Stress Response ◽  
Endoplasmic Reticulum Stress ◽  
Renal Injury ◽  
Endoplasmic Reticulum Stress Response ◽  
Chemically Induced

scholarly journals A Melanin-like Nanoenzyme for Acute Lung Injury Therapy via Suppressing Oxidative and Endoplasmic Reticulum Stress Response

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1850
Author(s):  
Xue-Fang Lou ◽  
Chen Wang ◽  
Ju-Cong Zhang ◽  
Yong-Zhong Du ◽  
Xiao-Ling Xu
Keyword(s):  
Endoplasmic Reticulum ◽  
Acute Lung Injury ◽  
Stress Response ◽  
Lung Injury ◽  
Endoplasmic Reticulum Stress ◽  
Therapeutic Effect ◽  
Neutrophil Infiltration ◽  
Endoplasmic Reticulum Stress Response ◽  
Ros Scavenging

Nanoenzyme-mediated catalytic activity is emerging as a novel strategy for reactive oxygen species (ROS) scavenging in acute lung injury (ALI) treatment. However, one of the main hurdles for these metal-containing nanoenzymes is their potential toxicity and single therapeutic mechanism. Herein, we uncovered a melanin-like nanoparticles derived from the self-polymerization of 1,8-dihydroxynaphthalene (PDH nanoparticles), showing a significant anti-inflammation therapeutic effect on ALI mice. The prepared PDH nanoparticles rich in phenol groups could not only act as radical scavengers to alleviate oxidative stress but could also chelate calcium overload to suppress the endoplasmic reticulum stress response. As revealed by the therapeutic effect in vivo, PDH nanoparticles significantly prohibited neutrophil infiltration and the secretion of proinflammatory cytokines (TNF-α and IL-6), thus improving the inflammatory cascade in the ALI model. Above all, our work provides an effective anti-inflammatory nanoplatform by using the inherent capability of melanin-like nanoenzymes, proposing the potential application prospects of these melanin-like nanoparticles for acute inflammation-induced injury treatment.

scholarly journals Activation of ATF6 and an ATF6 DNA Binding Site by the Endoplasmic Reticulum Stress Response

2000 ◽  
Vol 275 (35) ◽  
pp. 27013-27020
Author(s):  
Yan Wang ◽  
Jingshi Shen ◽  
Natalia Arenzana ◽  
Witoon Tirasophon ◽  
Randal J. Kaufman ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Stress Response ◽  
Dna Binding ◽  
Endoplasmic Reticulum Stress ◽  
Binding Site ◽  
Endoplasmic Reticulum Stress Response ◽  
Dna Binding Site

scholarly journals Involvement of Endoplasmic Reticulum Stress Response in Orofacial Inflammatory Pain

2014 ◽  
Vol 23 (4) ◽  
pp. 372-380 ◽  
Author(s):  
Eun Sun Yang ◽  
Jin Young Bae ◽  
Tae Heon Kim ◽  
Yun Sook Kim ◽  
Kyoungho Suk ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Stress Response ◽  
Endoplasmic Reticulum Stress ◽  
Inflammatory Pain ◽  
Endoplasmic Reticulum Stress Response

scholarly journals TSLP production by dendritic cells is modulated by IL-1β and components of the endoplasmic reticulum stress response

2015 ◽  
Vol 46 (2) ◽  
pp. 455-463 ◽  
Author(s):  
Matthew J. Elder ◽  
Steven J. Webster ◽  
David L. Williams ◽  
J. S. Hill Gaston ◽  
Jane C. Goodall
Keyword(s):  
Endoplasmic Reticulum ◽  
Dendritic Cells ◽  
Stress Response ◽  
Endoplasmic Reticulum Stress ◽  
Endoplasmic Reticulum Stress Response
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